IPSALAZIDE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H13N3O6
Molecular Weight	343.2909
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

SMILES

OC(=O)CNC(=O)C1=CC=C(C=C1)\N=N\C2=CC=C(O)C(=C2)C(O)=O

InChI

InChIKey=CQSRTOJJBONKMC-VHEBQXMUSA-N

InChI=1S/C16H13N3O6/c20-13-6-5-11(7-12(13)16(24)25)19-18-10-3-1-9(2-4-10)15(23)17-8-14(21)22/h1-7,20H,8H2,(H,17,23)(H,21,22)(H,24,25)/b19-18+

HIDE SMILES / InChI

Molecular Formula	C16H13N3O6
Molecular Weight	343.2909
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description

IPSALAZIDE is a sulfasalazine analog designed as a colon-specific delivery system for the treatment of inflammatory bowel disease by releasing 5-aminosalicylic acid in the gastrointestinal tract.

Originator

Approval Year

PubMed

Title	Date	PubMed
Studies of two novel sulfasalazine analogs, ipsalazide and balsalazide.	1983 Jul	6345112

Patents

Substance Class	Chemical
Record UNII	499H4332KZ
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

IPSALAZIDE

Official Name

English

IPSALAZIDE [MART.]

Common Name

English

BX-650A

Code

English

BX 650 A

Code

English

BX-650 A

Code

English

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Classification Tree

Code System

Code

Analgesic and Antipyretic

NCI_THESAURUS

C257

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Code System

Code

Type

Description

NCI_THESAURUS

C73087

PRIMARY

INN

5222

PRIMARY

EVMPD

SUB08289MIG

PRIMARY

SMS_ID

100000083128

PRIMARY

PUBCHEM

9571082

PRIMARY

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Related Record

Type

Details


					7V624678YX

INTESTINAL MICROBIOTA

METABOLIC ENZYME -> SUBSTRATE

Amount:

Showing 1 to 1 of 1 entries

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Related Record

Type

Details


					Y79XT83BJ9

AMINOHIPPURIC ACID

METABOLITE -> PARENT

Interaction Type:

AMOUNT ADMINISTERED

Qualification:

URINE

Amount:

45 % (average)


					4Q81I59GXC

MESALAMINE

METABOLITE ACTIVE -> PRODRUG


					Y79XT83BJ9

AMINOHIPPURIC ACID

METABOLITE -> PARENT

Interaction Type:

AMOUNT ADMINISTERED

Qualification:

FECAL

Amount:

8 % (average)

Showing 1 to 3 of 3 entries

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