IPSALAZIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H13N3O6
Molecular Weight	343.2909
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CNC(=O)C1=CC=C(C=C1)\N=N\C2=CC=C(O)C(=C2)C(O)=O

InChI

InChIKey=CQSRTOJJBONKMC-VHEBQXMUSA-N

InChI=1S/C16H13N3O6/c20-13-6-5-11(7-12(13)16(24)25)19-18-10-3-1-9(2-4-10)15(23)17-8-14(21)22/h1-7,20H,8H2,(H,17,23)(H,21,22)(H,24,25)/b19-18+

HIDE SMILES / InChI

Molecular Formula	C16H13N3O6
Molecular Weight	343.2909
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67038636 | https://www.ncbi.nlm.nih.gov/pubmed/6345112

IPSALAZIDE is a sulfasalazine analog designed as a colon-specific delivery system for the treatment of inflammatory bowel disease by releasing 5-aminosalicylic acid in the gastrointestinal tract.

Originator

Approval Year

PubMed

Title	Date	PubMed
Studies of two novel sulfasalazine analogs, ipsalazide and balsalazide.	1983 Jul	6345112
Clinical pharmacokinetics of sulphasalazine, its metabolites and other prodrugs of 5-aminosalicylic acid.	1985 Jul-Aug	2864155
Novel oral colon-specific drug delivery systems for pharmacotherapy of peptide and nonpeptide drugs.	1999 Jul	12973398

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:28:59 GMT 2023` Edited by `admin` on `Fri Dec 15 16:28:59 GMT 2023`
Record UNII	499H4332KZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IPSALAZIDE

Official Name

English

IPSALAZIDE [MART.]

Common Name

English

BX-650A

Code

English

BX 650 A

Code

English

BX-650 A

Code

English

ipsalazide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257