AUROTHIOGLYCANIDE

US Previously Marketed

First approved in 1945

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H8NOS.Au
Molecular Weight	363.187
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Au+].[S-]CC(=O)NC1=CC=CC=C1

InChI

InChIKey=ODENGJOFMCVWCT-UHFFFAOYSA-M

InChI=1S/C8H9NOS.Au/c10-8(6-11)9-7-4-2-1-3-5-7;/h1-5,11H,6H2,(H,9,10);/q;+1/p-1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14857605 | https://www.ncbi.nlm.nih.gov/pubmed/21064987 | https://www.ncbi.nlm.nih.gov/pubmed/20323872

AUROTHIOGLYCANIDE is a gold compound used in the management of rheumatoid arthritis. The mechanism of its action remains unknown.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Rheumatoid Arthritis 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13052489 https://www.ncbi.nlm.nih.gov/pubmed/20323872 https://www.ncbi.nlm.nih.gov/pubmed/21064987	Primary		Approved 8429	LAURON Approved Use Antiarthritic

Doses

Dose	Population	Adverse events
100 mg 1 times / week steady, intramuscular (max) Dose: 100 mg, 1 times / week Route: intramuscular Route: steady Dose: 100 mg, 1 times / week Sources: https://pubmed.ncbi.nlm.nih.gov/13151835	unhealthy, 52 years (range: 18-72 years) n = 56 Health Status: unhealthy Condition: rheumatoid arthritis Age Group: 52 years (range: 18-72 years) Sex: M+F Population Size: 56 Sources: https://pubmed.ncbi.nlm.nih.gov/13151835	Disc. AE: Thrombocytopenic purpura... AEs leading to discontinuation/dose reduction: Thrombocytopenic purpura (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/13151835

AEs

AE	Significance	Dose	Population
Thrombocytopenic purpura	1 patient Disc. AE	100 mg 1 times / week steady, intramuscular (max) Dose: 100 mg, 1 times / week Route: intramuscular Route: steady Dose: 100 mg, 1 times / week Sources: https://pubmed.ncbi.nlm.nih.gov/13151835	unhealthy, 52 years (range: 18-72 years) n = 56 Health Status: unhealthy Condition: rheumatoid arthritis Age Group: 52 years (range: 18-72 years) Sex: M+F Population Size: 56 Sources: https://pubmed.ncbi.nlm.nih.gov/13151835

Sourcing

Vendor/Aggregator	ID	URL
AAA Chemistry	AR-1J1351
ABI Chem	AC1L1V2Q
ABI Chem	AC1O1BIF
ChemIDplus	500947	https://chem.nlm.nih.gov/chemidplus/id/0000500947
ChemTik	CTK4J2133
EPA DSSTox	DTXSID80198176	https://comptox.epa.gov/dashboard/DTXSID80198176
Japan Chemical Substance Dictionary (Nikkaji)	J9.061A	http://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J9.061A
PubChem	102331733	https://pubchem.ncbi.nlm.nih.gov/compound/102331733
PubChem	10381	https://pubchem.ncbi.nlm.nih.gov/compound/10381
PubChem	138394114	https://pubchem.ncbi.nlm.nih.gov/compound/138394114
PubChem	6093181	https://pubchem.ncbi.nlm.nih.gov/compound/6093181
SureChEMBL	SCHEMBL103220	https://www.surechembl.org/chemical/SCHEMBL103220

PubMed

Title	Date	PubMed
Lauron in rheumatoid arthritis; a further report.	1946 Aug	21064987
Clinical evaluation of aurothioglycolanilide (Lauron-Endo) in rheumatoid arthritis.	1951 Aug	14857605

Name

Type

Language

AUROTHIOGLYCANIDE

Official Name

English

S-GOLD DERIVATIVE OF 2-MERCAPTOACETANILIDE

Common Name

English

(2-MERCAPTO-N-PHENYLACETAMIDATO-O,S)GOLD

Common Name

English

AUROTHIOGLYCOLIC ACID ANILIDE

Common Name

English

aurothioglycanide [INN]

Common Name

English

2-MERCAPTOACETANILIDE S-GOLD DERIVATIVE

Common Name

English

.ALPHA.-AUROMERCAPTOACETANILIDE

Common Name

English

(((PHENYLCARBAMOYL)METHYL)THIO)GOLD

Systematic Name

English

AUROTHIOGLYCOLANILIDE

Common Name

English

AUROTHIOGLYCANIDE [MI]

Common Name

English

Code System Code Type Description

PUBCHEM

10381