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Details

Stereochemistry ACHIRAL
Molecular Formula C8H14NO
Molecular Weight 140.2032
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 1

SHOW SMILES / InChI
Structure of FURTRETHONIUM

SMILES

C[N+](C)(C)Cc1ccco1

InChI

InChIKey=HEDXEAAVEOJUCR-UHFFFAOYSA-N
InChI=1S/C8H14NO/c1-9(2,3)7-8-5-4-6-10-8/h4-6H,7H2,1-3H3/q+1

HIDE SMILES / InChI
FURTRETHONIUM is an agonist of muscarinic acetylcholine receptors. It was used for the treatment of glaucoma.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Furmethide

Approved Use

Furtrethonum is a parasympathomimetic drug used for the treatment of glaucoma
Doses

Doses

DosePopulationAdverse events​
10 % 1 times / day multiple, ophthalmic
Dose: 10 %, 1 times / day
Route: ophthalmic
Route: multiple
Dose: 10 %, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
Disc. AE: Dacryostenosis acquired...
AEs leading to
discontinuation/dose reduction:
Dacryostenosis acquired (71%)
Sources:
AEs

AEs

AESignificanceDosePopulation
Dacryostenosis acquired 71%
Disc. AE
10 % 1 times / day multiple, ophthalmic
Dose: 10 %, 1 times / day
Route: ophthalmic
Route: multiple
Dose: 10 %, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
PubMed

PubMed

TitleDatePubMed
Glaucoma treatment by furnethide and diisopropylfluorophosphate.
1949 Jul
Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors.
1997 Jul
Patents

Patents

Name Type Language
FURTRETHONIUM
MI  
Common Name English
FURTRIMETHONIUM
Common Name English
FURTRETHONIUM [MI]
Common Name English
AMMONIUM, FURFURYLTRIMETHYL-
Systematic Name English
FURFURYLTRIMETHYLAMMONIUM
Systematic Name English
2-FURANMETHANAMINIUM, N,N,N-TRIMETHYL-
Systematic Name English
FURTRETONIUM
Common Name English
FURTRETHONIUM CATION
Common Name English
FURTRETHONIUM ION
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C47792
Created by admin on Sat Jun 26 12:06:04 UTC 2021 , Edited by admin on Sat Jun 26 12:06:04 UTC 2021
Code System Code Type Description
PUBCHEM
10938
Created by admin on Sat Jun 26 12:06:04 UTC 2021 , Edited by admin on Sat Jun 26 12:06:04 UTC 2021
PRIMARY
CAS
7618-86-2
Created by admin on Sat Jun 26 12:06:04 UTC 2021 , Edited by admin on Sat Jun 26 12:06:04 UTC 2021
PRIMARY
EPA CompTox
7618-86-2
Created by admin on Sat Jun 26 12:06:04 UTC 2021 , Edited by admin on Sat Jun 26 12:06:04 UTC 2021
PRIMARY
FDA UNII
AIQ630U6XO
Created by admin on Sat Jun 26 12:06:04 UTC 2021 , Edited by admin on Sat Jun 26 12:06:04 UTC 2021
PRIMARY
MESH
C028530
Created by admin on Sat Jun 26 12:06:04 UTC 2021 , Edited by admin on Sat Jun 26 12:06:04 UTC 2021
PRIMARY
MERCK INDEX
M5611
Created by admin on Sat Jun 26 12:06:04 UTC 2021 , Edited by admin on Sat Jun 26 12:06:04 UTC 2021
PRIMARY Merck Index
NCI_THESAURUS
C72790
Created by admin on Sat Jun 26 12:06:04 UTC 2021 , Edited by admin on Sat Jun 26 12:06:04 UTC 2021
PRIMARY
DRUG CENTRAL
3256
Created by admin on Sat Jun 26 12:06:04 UTC 2021 , Edited by admin on Sat Jun 26 12:06:04 UTC 2021
PRIMARY