FURTRETHONIUM

C[N+](C)(C)CC1=CC=CO1

InChIKey=HEDXEAAVEOJUCR-UHFFFAOYSA-N

InChI=1S/C8H14NO/c1-9(2,3)7-8-5-4-6-10-8/h4-6H,7H2,1-3H3/q+1

FURTRETHONIUM is an agonist of muscarinic acetylcholine receptors. It was used for the treatment of glaucoma.

Condition	Modality	Targets	Highest Phase	Product
Glaucoma 57	Primary		Approved 8,429	Furmethide

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Dose	Population	Adverse events
10 % 1 times / day multiple, ophthalmic	unhealthy n = 21	Disc. AE: Dacryostenosis acquired...

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AE	Significance	Dose	Population
Dacryostenosis acquired	71% Disc. AE	10 % 1 times / day multiple, ophthalmic	unhealthy n = 21

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Vendor/Aggregator	ID	URL
ABI Chem	AC1L1W9Q
BOC Sciences	541-64-0
ChemMol	99154117	http://www.chemmol.com/chemmol/99154117.html
Enamine	BBV-82745797
Enamine	EN300-1588178

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Title	Date	PubMed
Further studies on the use of furmethide in the treatment of glaucoma.	1946 Apr	21019950
Glaucoma treatment by furnethide and diisopropylfluorophosphate.	1949 Jul	18134262
Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors.	1997 Jul	9224827