ASPARTIC ACID

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C4H7NO4
Molecular Weight	133.1027
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N[C@@H](CC(O)=O)C(O)=O

InChI

InChIKey=CKLJMWTZIZZHCS-REOHCLBHSA-N

InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C4H7NO4
Molecular Weight	133.1027
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.worldcat.org/title/fundamentals-of-biochemistry-life-at-the-molecular-level/oclc/910538334Advances in Protein Chemistry (1945), v.2, p.308, retrieved from: https://books.google.ru/books?id=QRyhIaEwrngC
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/15703381 | https://www.ncbi.nlm.nih.gov/pubmed/3814227 | https://www.ncbi.nlm.nih.gov/pubmed/16061593

Disodium aspartate is used in organic biosynthesis.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Isoaspartyl peptidase/L-asparaginase 8 Target ID: Q7L266 Gene ID: 80150.0 Gene Symbol: ASRGL1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/3334241 \| https://www.ncbi.nlm.nih.gov/pubmed/7056352	Interacts 323
Glutamate [NMDA] receptor 125 Target ID: CHEMBL2094124 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15703381	Activator 1447	18.4 µM [EC50]
Beta-glucuronidase 13 Target ID: P08236 Gene ID: 2990.0 Gene Symbol: GUSB Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/16061593	Inhibitor 8504

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2596
Opiate abstinence syndrome 8 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3814227	Primary	Natural Metabolite	Unknown Approved Use Unknown
Neonatal jaundice 8 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16061593	Primary	Natural Metabolite	Unknown Approved Use Unknown

Doses

Dose	Population	Adverse events
6 g 1 times / day multiple, oral Highest studied dose Dose: 6 g, 1 times / day Route: oral Route: multiple Dose: 6 g, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/28841667	healthy, 22.4 ± 2.6 years Health Status: healthy Age Group: 22.4 ± 2.6 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/28841667	Sources: https://pubmed.ncbi.nlm.nih.gov/28841667

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
OAT1 725	Aspartoacylase 8 ASNS 8 ASCT2 12 ASCT1 8 SLC22A13 8 OAT1 395

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
OAT1 730	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/23255614/ Page: -	no

Drug as victim

Target	Modality	Activity
OAT1 395	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/23255614/ Page: -	no
ASCT1 8	substrate 4014 Sources: https://onlinelibrary.wiley.com/doi/full/10.1046/j.1471-4159.2003.02063.x Page: -	yes
ASCT2 12	substrate 4014 Sources: https://onlinelibrary.wiley.com/doi/full/10.1046/j.1471-4159.2003.02063.x Page: -	yes
ASNS 8	substrate 4014 Sources: https://www.sciencedirect.com/science/article/pii/S1096719215300421 Page: -	yes
Aspartoacylase 8	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/12706335/ Page: -	yes
SLC22A13 8	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/24147638/ Page: -	yes

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:22660	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:22660
ChemicalBook	CB7233502	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB7233502
eMolecules	478747	https://www.emolecules.com/cgi-bin/more?vid=478747
MolPort	MolPort-001-781-456	https://www.molport.com/shop/molecule-link/MolPort-001-781-456
MolPort	MolPort-047-345-807	https://www.molport.com/shop/molecule-link/MolPort-047-345-807

PubMed

Title	Date	PubMed
Protective effect of allopurinol on hepatic energy metabolism in ischemic and reperfused rat liver.	2001 Feb	11220638
Increase of chemokine interferon-inducible protein-10 (IP-10) in the serum of patients with autoimmune liver diseases and increase of its mRNA expression in hepatocytes.	2001 Feb	11207658
Endotoxin clearance and its relation to hepatic and renal disturbances in rats with liver cirrhosis.	2001 Feb	11169075
DNA-protein crosslinks induced by nickel compounds in isolated rat lymphocytes: role of reactive oxygen species and specific amino acids.	2001 Feb 1	11162780
Sodium nitroprusside-induced seizures and adenosine release in rat hippocampus.	2001 Feb 16	11226393
Evidence for microvesicular storage and release of glycine in rodent pinealocytes.	2001 Feb 16	11166946
Probing the mechanism of inactivation of human pyruvate dehydrogenase by phosphorylation of three sites.	2001 Feb 23	11092882
Covariate effects on the apparent clearance of tacrolimus in paediatric liver transplant patients undergoing conversion therapy.	2001 Jan	11236810
Plasma ascorbate concentrations are not correlated with milk somatic cell count and metabolic profile in lactating and dry cows.	2001 Jan	11210025
Dietary cancer risk from conditional cancerogens (tumor promoters) in produce of livestock fed on species of spurge (Euphorbiaceae). IV. Toxicologic and pathophysiologic observations in lactating goats and their suckling kids fed on the irritant herbs Euphorbia nubica and Euphorbia helioscopia: an etiologic model for investigations on the putative risk of cancer by consumption of food p.	2001 Jan	11206269
Portal-Systemic shunts reduce asialoglycoprotein receptor density in rats.	2001 Jan	11197958
Leukocyte filtration in the early reperfusion phase on cardiopulmonary bypass reduces myocardial injury.	2001 Jan	11192307
Effects of aflatoxin and carotenoids on growth performance and immune response in mule ducklings.	2001 Jan	11166670
Effect of early arterialization of the porcine liver allograft on reperfusion injury, hepatocellular injury, and endothelial cell dysfunction.	2001 Jan	11150419
Altered striatal amino acid neurotransmitter release monitored using microdialysis in R6/1 Huntington transgenic mice.	2001 Jan	11135020
alpha(2)-Adrenoceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia.	2001 Jan	11123383
Two basic residues of the h-VPAC1 receptor second transmembrane helix are essential for ligand binding and signal transduction.	2001 Jan 12	11013258
Three-dimensional structure of Erwinia chrysanthemi pectin methylesterase reveals a novel esterase active site.	2001 Jan 26	11162105
Positive and negative strands of HCV-RNA in sera and peripheral blood mononuclear cells of chronically hemodialyzed patients.	2001 Jan-Feb	11208504
Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population.	2001 Mar	11171930
Differential effects of endomorphin-1 and -2 on amphetamine sensitization: neurochemical and behavioral aspects.	2001 Mar 1	11169772

Patents

Sample Use Guides

In Vivo Use Guide

Aspartic acid is a nutrient component found in animal and vegetable sources. In clinical trials to alleviate opioid abstinence it was administered orally.

Route of Administration: Oral

In Vitro Use Guide

Activation of recombinant NMDA receptors was measured using two-electrode voltage clamp. Current and voltage electrodes were made from thin-walled borosilicate glass using a PP-830 electrode puller and when filled with 3 M KCl, possessed resistances of between 0.5 and 1.5 MΩ. Oocytes were voltage-clamped at potentials of -40 mV. Aspartate was able to activate wild type NR1/NR2A NMDA receptors with EC50 of 18.4 uM.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:35:16 GMT 2025` Edited by `admin` on `Mon Mar 31 17:35:16 GMT 2025`
Record UNII	30KYC7MIAI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

L-ASPARTIC ACID

Preferred Name

English

ASPARTIC ACID

Official Name

English

ASPARTIC ACID [USP MONOGRAPH]

Common Name

English

ASPARTIC ACID [MI]

Common Name

English

ASPARTIC ACID [HSDB]

Common Name

English

ALANINE IMPURITY A [EP IMPURITY]

Common Name

English

L-ASPARTIC ACID [FCC]

Common Name

English

ASPARTIC ACID [II]

Common Name

English

L-ASPARTIC ACID [FHFI]

Common Name

English

ASPARTIC ACID [MART.]

Common Name

English

DEAMIDATED ASPARAGINE

Common Name

English

ASPARTIC ACID [USAN]

Common Name

English

Aspartic acid [WHO-DD]

Common Name

English

FEMA NO. 3656

Code

English

ASPARTIC ACID [VANDF]

Common Name

English

ASPARTIC ACID [USP-RS]

Common Name

English

LYSINE ACETATE IMPURITY A [EP IMPURITY]

Common Name

English

L-ASPARTIC ACID [JAN]

Common Name

English

aspartic acid [INN]

Common Name

English

ASPARTIC ACID [EP MONOGRAPH]

Common Name

English

ASPARTIC ACID, L-

Common Name

English

(2S)-2-AMINOBUTANEDIOIC ACID

Systematic Name

English

ASPARTIC ACID [EP IMPURITY]

Common Name

English

ASPARTATE

Systematic Name

English

Classification Tree Code System Code

LOINC

1911-7