ASPARTIC ACID

First marketed in 1921

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C4H7NO4
Molecular Weight	133.1027
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N[C@@H](CC(O)=O)C(O)=O

InChI

InChIKey=CKLJMWTZIZZHCS-REOHCLBHSA-N

InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C4H7NO4
Molecular Weight	133.1027
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.worldcat.org/title/fundamentals-of-biochemistry-life-at-the-molecular-level/oclc/910538334Advances in Protein Chemistry (1945), v.2, p.308, retrieved from: https://books.google.ru/books?id=QRyhIaEwrngC
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/15703381 | https://www.ncbi.nlm.nih.gov/pubmed/3814227 | https://www.ncbi.nlm.nih.gov/pubmed/16061593

Disodium aspartate is used in organic biosynthesis.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Isoaspartyl peptidase/L-asparaginase 8 Target ID: Q7L266 Gene ID: 80150.0 Gene Symbol: ASRGL1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/3334241 \| https://www.ncbi.nlm.nih.gov/pubmed/7056352	Interacts 323
Glutamate [NMDA] receptor 125 Target ID: CHEMBL2094124 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15703381	Activator 1430	18.4 µM [EC50]
Beta-glucuronidase 13 Target ID: P08236 Gene ID: 2990.0 Gene Symbol: GUSB Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/16061593	Inhibitor 8297

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2578
Opiate abstinence syndrome 8 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3814227	Primary	Natural Metabolite	Unknown Approved Use Unknown
Neonatal jaundice 8 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16061593	Primary	Natural Metabolite	Unknown Approved Use Unknown

Doses

Dose	Population	Adverse events
6 g 1 times / day multiple, oral Highest studied dose Dose: 6 g, 1 times / day Route: oral Route: multiple Dose: 6 g, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/28841667	healthy, 22.4 ± 2.6 years n = 10 Health Status: healthy Age Group: 22.4 ± 2.6 years Sex: M Population Size: 10 Sources: https://pubmed.ncbi.nlm.nih.gov/28841667	Sources: https://pubmed.ncbi.nlm.nih.gov/28841667

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
OAT1 599	Aspartoacylase 8 ASNS 8 ASCT2 12 ASCT1 8 SLC22A13 8 OAT1 326

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
OAT1 603	inhibitor 3277 Sources: https://pubmed.ncbi.nlm.nih.gov/23255614/ Page: -	no

Drug as victim

Target	Modality	Activity
OAT1 326	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/23255614/ Page: -	no
ASCT1 8	substrate 3367 Sources: https://onlinelibrary.wiley.com/doi/full/10.1046/j.1471-4159.2003.02063.x Page: -	yes
ASCT2 12	substrate 3367 Sources: https://onlinelibrary.wiley.com/doi/full/10.1046/j.1471-4159.2003.02063.x Page: -	yes
ASNS 8	substrate 3367 Sources: https://www.sciencedirect.com/science/article/pii/S1096719215300421 Page: -	yes
Aspartoacylase 8	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/12706335/ Page: -	yes
SLC22A13 8	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/24147638/ Page: -	yes

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:22660	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:22660
ChemicalBook	CB7233502	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB7233502
MolPort	MolPort-001-781-456	https://www.molport.com/shop/molecule-link/MolPort-001-781-456
MolPort	MolPort-047-345-807	https://www.molport.com/shop/molecule-link/MolPort-047-345-807
eMolecules	478747	https://www.emolecules.com/cgi-bin/more?vid=478747

PubMed

Title	Date	PubMed
Ketanserin for the treatment of preeclampsia.	2001	11234612
Characterization of the protective effects of melatonin and related indoles against alpha-naphthylisothiocyanate-induced liver injury in rats.	2001	11169730
Metabolism of [1-(13)C)glucose and [2-(13)C]acetate in the hypoxic rat brain.	2001 Apr	11222920
Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family.	2001 Apr 13	11152695
Identification and characterization of asporin. a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan.	2001 Apr 13	11152692
Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies.	2001 Feb	11234874
Aging-induced changes in 24-h rhythms of mitogenic responses, lymphocyte subset populations and neurotransmitter and amino acid content in rat submaxillary lymph nodes during Freund's adjuvant arthritis.	2001 Feb	11226742
Differences between GABA levels in Alzheimer's disease and Down syndrome with Alzheimer-like neuropathology.	2001 Feb	11218066
Factors associated with the risk of liver enzyme elevation in patients with type 2 diabetes treated with a thiazolidinedione.	2001 Feb	11213855
Nicotinic receptors mediate the release of amino acid neurotransmitters in cultured cortical neurons.	2001 Feb	11208670
Design, X-ray crystallography, molecular modelling and thermal stability studies of mutant enzymes at site 172 of 3-isopropylmalate dehydrogenase from Thermus thermophilus.	2001 Feb	11173468
Endotoxin clearance and its relation to hepatic and renal disturbances in rats with liver cirrhosis.	2001 Feb	11169075
Severe veno-occlusive disease after allogeneic bone marrow or peripheral stem cell transplantation--role of transjugular intrahepatic portosystemic shunt (TIPS).	2001 Feb	11169070
Extracellular amino acid levels measured with intracerebral microdialysis in the model of posttraumatic epilepsy induced by intracortical iron injection.	2001 Feb	11164702
Serum hepatic biochemical activity in two populations of workers exposed to styrene.	2001 Feb	11160987
Molecular mechanism of action at estrogen receptor alpha of a new clinically relevant antiestrogen (GW7604) related to tamoxifen.	2001 Feb	11159857
Central infusions of the recombinant human prolactin receptor antagonist, S179D-PRL, delay the onset of maternal behavior in steroid-primed, nulliparous female rats.	2001 Feb	11159845
A molecular variant of the APC gene at codon 1822: its association with diet, lifestyle, and risk of colon cancer.	2001 Feb 1	11221825
DNA-protein crosslinks induced by nickel compounds in isolated rat lymphocytes: role of reactive oxygen species and specific amino acids.	2001 Feb 1	11162780
Protective effect of stiripentol on acetaminophen-induced hepatotoxicity in rat.	2001 Feb 1	11162779
Alteration of caspases and apoptosis-related proteins in brains of patients with Alzheimer's disease.	2001 Feb 16	11178964
Evidence for microvesicular storage and release of glycine in rodent pinealocytes.	2001 Feb 16	11166946
Phosphorylation-induced change of the oligomerization state of alpha B-crystallin.	2001 Feb 16	11096101
A novel osteopontin-like protein is expressed in the trout ovary during ovulation.	2001 Feb 2	11165234
Covariate effects on the apparent clearance of tacrolimus in paediatric liver transplant patients undergoing conversion therapy.	2001 Jan	11236810
Comparison of the efficacy and tolerability of fluvastatin extended-release and immediate-release formulations in the treatment of primary hypercholesterolemia: a randomized trial.	2001 Jan	11219479
Maintenance of primary murine hepatocyte functions in multicomponent polymer capsules--in vitro cryopreservation studies.	2001 Jan	11211886
Relationship between crevicular aspartate aminotransferase levels and periodontal disease progression.	2001 Jan	11210069
Use of intraosseous blood for repeated hematologic and biochemical analyses in healthy pigs.	2001 Jan	11197559
The effect of amino acid-modifying reagents on chloroplast protein import and the formation of early import intermediates.	2001 Jan	11181713
Ehlers-Danlos syndrome type IV with a unique point mutation in COL3A1 and familial phenotype of myocardial infarction without organic coronary stenosis.	2001 Jan	11168790
Effects of aflatoxin and carotenoids on growth performance and immune response in mule ducklings.	2001 Jan	11166670
Lactococcus lactis LM0230 contains a single aminotransferase involved in aspartate biosynthesis, which is essential for growth in milk.	2001 Jan	11160815
Effect of early arterialization of the porcine liver allograft on reperfusion injury, hepatocellular injury, and endothelial cell dysfunction.	2001 Jan	11150419
Redistribution of neuroactive amino acids in hippocampus and striatum during hypoglycemia: a quantitative immunogold study.	2001 Jan	11149667
Excitatory amino acid concentrations in ventricular cerebrospinal fluid after severe traumatic brain injury in infants and children: the role of child abuse.	2001 Jan	11148507
Pregnancy complicated by pre-eclampsia-eclampsia with HELLP syndrome.	2001 Jan	11146072
Possible linkage between glutamate transporter and mitogen-activated protein kinase cascade in cultured rat cortical astrocytes.	2001 Jan	11145995
alpha(2)-Adrenoceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia.	2001 Jan	11123383
The effect of ketamine hydrochloride anesthesia on basal and N-methyl-D,L-aspartate induced plasma prolactin secretion in the adult male rhesus monkey.	2001 Jan 19	11212871
Three-dimensional structure of Erwinia chrysanthemi pectin methylesterase reveals a novel esterase active site.	2001 Jan 26	11162105
Simplified technique of orthotopic liver transplantation in pigs.	2001 Jan 27	11213081
Inhibition of evoked glutamate release by the neuroprotective 5-HT(1A) receptor agonist BAY x 3702 in vitro and in vivo.	2001 Jan 5	11146061
The effect of repeated gavage doses of fumonisin B1 on the sphinganine and sphingosine levels in vervet monkeys.	2001 Jul	11223085
Stress responses and changes in protein metabolism in carp Cyprinus carpio during cadmium exposure.	2001 Mar	11222034
Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population.	2001 Mar	11171930
In vivo evidence for accelerated generation of hydroxyl radicals in liver of Long-Evans Cinnamon (LEC) rats with acute hepatitis.	2001 Mar 1	11182525
Site-directed mutations in the mitochondrially encoded subunits I and III of yeast cytochrome oxidase.	2001 Mar 1	11171120
Differential effects of endomorphin-1 and -2 on amphetamine sensitization: neurochemical and behavioral aspects.	2001 Mar 1	11169772
Pathobiochemical mechanisms involved in the control of the disease caused by Trypanosoma congolense in African grey duiker (Sylvicapra grimmia).	2001 Mar 5	11182235

Patents

Sample Use Guides

In Vivo Use Guide

Aspartic acid is a nutrient component found in animal and vegetable sources. In clinical trials to alleviate opioid abstinence it was administered orally.

Route of Administration: Oral

In Vitro Use Guide

Activation of recombinant NMDA receptors was measured using two-electrode voltage clamp. Current and voltage electrodes were made from thin-walled borosilicate glass using a PP-830 electrode puller and when filled with 3 M KCl, possessed resistances of between 0.5 and 1.5 MΩ. Oocytes were voltage-clamped at potentials of -40 mV. Aspartate was able to activate wild type NR1/NR2A NMDA receptors with EC50 of 18.4 uM.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:00:57 GMT 2023` Edited by `admin` on `Fri Dec 15 15:00:57 GMT 2023`
Record UNII	30KYC7MIAI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ASPARTIC ACID

Official Name

English

L-ASPARTIC ACID

Systematic Name

English

ASPARTIC ACID [USP MONOGRAPH]

Common Name

English

ASPARTIC ACID [MI]

Common Name

English

ASPARTIC ACID [HSDB]

Common Name

English

ALANINE IMPURITY A [EP IMPURITY]

Common Name

English

L-ASPARTIC ACID [FCC]

Common Name

English

ASPARTIC ACID [II]

Common Name

English

L-ASPARTIC ACID [FHFI]

Common Name

English

ASPARTIC ACID [MART.]

Common Name

English

DEAMIDATED ASPARAGINE

Common Name

English

ASPARTIC ACID [USAN]

Common Name

English

Aspartic acid [WHO-DD]

Common Name

English

FEMA NO. 3656

Code

English

ASPARTIC ACID [VANDF]

Common Name

English

ASPARTIC ACID [USP-RS]

Common Name

English

LYSINE ACETATE IMPURITY A [EP IMPURITY]

Common Name

English

L-ASPARTIC ACID [JAN]

Common Name

English

aspartic acid [INN]

Common Name

English

ASPARTIC ACID [EP MONOGRAPH]

Common Name

English

ASPARTIC ACID, L-

Common Name

English

(2S)-2-AMINOBUTANEDIOIC ACID

Systematic Name

English

ASPARTIC ACID [INCI]

Common Name

English

ASPARTIC ACID [EP IMPURITY]

Common Name

English

ASPARTATE

Systematic Name

English

Classification Tree Code System Code

LOINC

1911-7