Details
Stereochemistry | RACEMIC |
Molecular Formula | C4H6O5 |
Molecular Weight | 134.0874 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(CC(O)=O)C(O)=O
InChI
InChIKey=BJEPYKJPYRNKOW-UHFFFAOYSA-N
InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)
Molecular Formula | C4H6O5 |
Molecular Weight | 134.0874 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
DescriptionSources: http://gov.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/FR330.pdf | https://www.montavit.com/sites/default/files/produktdownloads/pil_acerbine_solution_06022015.pdfhttp://www.cosmeticsinfo.org/ingredient/sodium-malate | https://www.food.gov.uk/science/additives/enumberlist#h_7 | https://www.ncbi.nlm.nih.gov/pubmed/11358110 | https://www.ncbi.nlm.nih.gov/pubmed/9477166
Sources: http://gov.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/FR330.pdf | https://www.montavit.com/sites/default/files/produktdownloads/pil_acerbine_solution_06022015.pdfhttp://www.cosmeticsinfo.org/ingredient/sodium-malate | https://www.food.gov.uk/science/additives/enumberlist#h_7 | https://www.ncbi.nlm.nih.gov/pubmed/11358110 | https://www.ncbi.nlm.nih.gov/pubmed/9477166
Malic acid is a tart-tasting organic dicarboxylic acid that contributes to the taste of many sour or tart foods such as apples. Sodium Malate is the sodium salt of Malic Acid. Malic Acid and Sodium Malate can be found in a wide range of cosmetics and personal care products. Sodium Malate functions as a skin conditioning agent-humectant. As a food additive, Sodium Malate has the E number E350. Sodium Malate has demonstrated protective effect on cisplatin-induced toxicity in mice. Sodium malate could become a useful agent for the reduction of CDDP-induced toxicity, particularly nephrotoxicity and hepatotoxicity.
Originator
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Secondary | Unknown Approved UseUnknown |
|||
Preventing | Unknown Approved UseUnknown |
|||
Curative | ACERBINE Approved UseAcerbine solution is suitable for the treatment of superficial skin injuries, such as burns, scalds, sunburn, wounds and abrasions. |
Doses
Dose | Population | Adverse events |
---|---|---|
1 % 8 times / day multiple, topical Studied dose Dose: 1 %, 8 times / day Route: topical Route: multiple Dose: 1 %, 8 times / day Sources: |
unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: |
|
600 mg 2 times / day multiple, oral Studied dose Dose: 600 mg, 2 times / day Route: oral Route: multiple Dose: 600 mg, 2 times / day Sources: |
unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: |
PubMed
Title | Date | PubMed |
---|---|---|
Variation of isoenzyme and RAPD patterns in Candida albicans morphological mutants with altered colony ultrastructure. | 2001 |
|
Isocitrate dehydrogenase, malate dehydrogenase, and glutamate dehydrogenase from Archaeoglobus fulgidus. | 2001 |
|
Survey of normal appearing mouse strain which lacks malic enzyme and Nad+-linked glycerol phosphate dehydrogenase: normal pancreatic beta cell function, but abnormal metabolite pattern in skeletal muscle. | 2001 Apr |
|
Physiological basis of reduced AL tolerance in ditelosomic lines of Chinese Spring wheat. | 2001 Apr |
|
Phlebotomine sandflies in Venezuela. V. Review of the genus Brumptomyia (Diptera: Psychodidae), with description of the female of Brumptomyia devenanzii, re-description of the male and isozymatic profile. | 2001 Apr |
|
Effect of an antidiabetic extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats. | 2001 Aug |
|
Structural analyses of a malate dehydrogenase with a variable active site. | 2001 Aug 17 |
|
Abscisic acid induces a decline in nitrogen fixation that involves leghaemoglobin, but is independent of sucrose synthase activity. | 2001 Feb |
|
High level expression of C4-specific NADP-malic enzyme in leaves and impairment of photoautotrophic growth in a C3 plant, rice. | 2001 Feb |
|
Exercise and ovarian steroid hormones: their effects on mitochondrial respiration. | 2001 Feb 16 |
|
Substrate and cofactor binding to fluorescently labeled cytoplasmic malate dehydrogenase. | 2001 Feb 9 |
|
Computerized analysis of cytochemical reactions for dehydrogenases and oxygraphic studies as methods to evaluate the function of the mitochondrial sheath in rat spermatozoa. | 2001 Jan |
|
[Lactate and malate dehydrogenase activity in the sterlet and Russian sturgeon under conditions of the widespread muscular pathology]. | 2001 Jan-Feb |
|
Malo-ethanolic fermentation in grape must by recombinant strains of Saccharomyces cerevisiae. | 2001 Jul |
|
Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific. | 2001 Jul |
|
Massive sequence comparisons as a help in annotating genomic sequences. | 2001 Jul |
|
pH-dependent investigations of vanadium(V)-peroxo-malate complexes from aqueous solutions. In search of biologically relevant vanadium(V)-peroxo species. | 2001 Jul 16 |
|
Transcriptome meets metabolome: hierarchical and metabolic regulation of the glycolytic pathway. | 2001 Jul 6 |
|
The first examples of (S)-2-hydroxyacid dehydrogenases catalyzing the transfer of the pro-4S hydrogen of NADH are found in the archaea. | 2001 Jul 9 |
|
The effect of nucleotides and mitochondrial chaperonin 10 on the structure and chaperone activity of mitochondrial chaperonin 60. | 2001 Jun |
|
An NMR-based metabonomic approach to the investigation of coelomic fluid biochemistry in earthworms under toxic stress. | 2001 Jun 29 |
|
Non-photosynthetic 'malic enzyme' from maize: a constituvely expressed enzyme that responds to plant defence inducers. | 2001 Mar |
|
Methyl pyruvate initiates membrane depolarization and insulin release by metabolic factors other than ATP. | 2001 Mar 1 |
|
Myxothiazol induces H(2)O(2) production from mitochondrial respiratory chain. | 2001 Mar 2 |
|
[Properties of gluconeogenesis enzymes from flatworms]. | 2001 Mar-Apr |
|
Production of beta-thujaplicin in Cupressus lusitanica suspension cultures fed with organic acids and monoterpenes. | 2001 May |
|
Cloning and functional characterization of the 5' flanking region of the human mitochondrial malic enzyme gene. Regulatory role of Sp1 and AP-2. | 2001 May |
|
Possible involvement of protein phosphorylation in aluminum-responsive malate efflux from wheat root apex. | 2001 May |
Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:50:51 GMT 2025
by
admin
on
Mon Mar 31 17:50:51 GMT 2025
|
Record UNII |
817L1N4CKP
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Code | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
CODEX ALIMENTARIUS (GSFA) |
INS-296
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
||
|
DSLD |
2323 (Number of products:281)
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
||
|
JECFA EVALUATION |
INS-296
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
||
|
LOINC |
13770-3
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
||
|
LOINC |
25113-2
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
||
|
JECFA EVALUATION |
DL-MALIC ACID
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
||
|
CFR |
21 CFR 184.1069
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
||
|
EPA PESTICIDE CODE |
51101
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
||
|
LOINC |
75068-7
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
25941
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
70612
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
ALTERNATIVE | |||
|
100000091777
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
1202
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
DB12751
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
C030298
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
617-48-1
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
SUPERSEDED | |||
|
29209
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
C80654
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
C45678
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
CONCEPT | Industrial Aid | ||
|
MALIC ACID
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
30797
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
210-514-9
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
DTXSID0027640
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
1374601
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
15595
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
817L1N4CKP
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
525
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
817L1N4CKP
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
6650
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
SUB14455MIG
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
m7041
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | Merck Index | ||
|
CHEMBL1455497
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
6915-15-7
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
SUB59600
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
PRIMARY | |||
|
230-022-8
Created by
admin on Mon Mar 31 17:50:51 GMT 2025 , Edited by admin on Mon Mar 31 17:50:51 GMT 2025
|
ALTERNATIVE |
Related Record | Type | Details | ||
---|---|---|---|---|
|
SALT/SOLVATE -> PARENT | |||
|
SALT/SOLVATE -> PARENT | |||
|
SALT/SOLVATE -> PARENT |
|
||
|
SALT/SOLVATE -> PARENT | |||
|
SALT/SOLVATE -> PARENT | |||
|
SALT/SOLVATE -> PARENT | |||
|
PARENT -> CONSTITUENT ALWAYS PRESENT |
Related Record | Type | Details | ||
---|---|---|---|---|
|
IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
|
||
|
PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
|
PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
|
IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
|
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |