U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula 2C4H5NO4.Zn.2H
Molecular Weight 329.598
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZINC ASPARTATE

SMILES

[H+].[H+].[Zn++].N[C@@H](CC([O-])=O)C([O-])=O.N[C@@H](CC([O-])=O)C([O-])=O

InChI

InChIKey=POEVDIARYKIEGF-CEOVSRFSSA-L
InChI=1S/2C4H7NO4.Zn/c2*5-2(4(8)9)1-3(6)7;/h2*2H,1,5H2,(H,6,7)(H,8,9);/q;;+2/p-2/t2*2-;/m00./s1

HIDE SMILES / InChI

Molecular Formula H
Molecular Weight 1.0079
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Zn
Molecular Weight 65.409
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C4H5NO4
Molecular Weight 131.0868
Charge -2
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Zinc aspartate is an approved drug, used to treat zinc deficiency in humans. Zinc aspartate regulates the production of the growth hormone and sex hormones (it is necessary for the production of sperm cells and egg cells). It reduces the body’s susceptibility to infections and allergies. It promotes the proper secretion of insulin by the pancreas. Zinc deficiency causes: disorders in the functioning of the skin, the digestive system, the nervous system, the immunological system, and the skeletal system. Significant zinc deficiency can cause dwarfism and genital underdevelopment. Zinc aspartate suppresses experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis (MS), as well as effector T cell functions in vitro.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions
PubMed

PubMed

TitleDatePubMed
Effect of oral zinc application during pregnancy.
1986
Synergism of organic zinc salts and sulfhydryl compounds (thiols) in the protection of mice against acute ethanol toxicity, and protective effects of various metal salts.
1987 Jun
Differential radioprotection of bone marrow and tumour cells by zinc aspartate.
1988 Jun
Further studies on selective radioprotection by organic zinc salts and synergism of zinc aspartate with WR 2721.
1990 Jun
Oral zinc aspartate treats experimental autoimmune encephalomyelitis.
2014 Dec
Zinc and propolis reduces cytotoxicity and proliferation in skin fibroblast cell culture: total polyphenol content and antioxidant capacity of propolis.
2014 Jul
Congenital diseases of the gastrointestinal tract.
2014 May
Patents

Sample Use Guides

For inflammatory bowel disease, 300 milligrams of zinc aspartate (equal to 60 milligrams of elemental zinc) has been taken by mouth daily for four weeks.
Route of Administration: Oral
Zinc aspartate, at a concentration of 16 uM, increased human fibroblasts proliferation in cell culture
Substance Class Chemical
Created
by admin
on Wed Jul 05 23:30:15 UTC 2023
Edited
by admin
on Wed Jul 05 23:30:15 UTC 2023
Record UNII
4OC7QTI23H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ZINC ASPARTATE
INCI  
INCI  
Official Name English
Aspartate zinc [WHO-DD]
Common Name English
ZINCATE(2-), BIS(L-ASPARTATO(2-)-.KAPPA.N,.KAPPA.O1)-, HYDROGEN (1:2), (T-4)-
Common Name English
ZINC ASPARTATE [INCI]
Common Name English
ZINCATE(2-), BIS(L-ASPARTATO(2-)-N,O(SUP 1))-, DIHYDROGEN, (T-4)-
Common Name English
ASPARTATE ZINC
WHO-DD  
Systematic Name English
DIHYDROGEN BIS(L-ASPARTATO(2-)-N,O1)ZINCATE(2-)
Common Name English
Classification Tree Code System Code
DSLD 137 (Number of products:9660)
Created by admin on Wed Jul 05 23:30:15 UTC 2023 , Edited by admin on Wed Jul 05 23:30:15 UTC 2023
Code System Code Type Description
EVMPD
SUB12952MIG
Created by admin on Wed Jul 05 23:30:15 UTC 2023 , Edited by admin on Wed Jul 05 23:30:15 UTC 2023
PRIMARY
FDA UNII
4OC7QTI23H
Created by admin on Wed Jul 05 23:30:15 UTC 2023 , Edited by admin on Wed Jul 05 23:30:15 UTC 2023
PRIMARY
RXCUI
236142
Created by admin on Wed Jul 05 23:30:15 UTC 2023 , Edited by admin on Wed Jul 05 23:30:15 UTC 2023
PRIMARY RxNorm
DAILYMED
4OC7QTI23H
Created by admin on Wed Jul 05 23:30:15 UTC 2023 , Edited by admin on Wed Jul 05 23:30:15 UTC 2023
PRIMARY
NCI_THESAURUS
C87349
Created by admin on Wed Jul 05 23:30:15 UTC 2023 , Edited by admin on Wed Jul 05 23:30:15 UTC 2023
PRIMARY
PUBCHEM
56841018
Created by admin on Wed Jul 05 23:30:15 UTC 2023 , Edited by admin on Wed Jul 05 23:30:15 UTC 2023
PRIMARY
ECHA (EC/EINECS)
253-012-5
Created by admin on Wed Jul 05 23:30:15 UTC 2023 , Edited by admin on Wed Jul 05 23:30:15 UTC 2023
PRIMARY
WIKIPEDIA
Zinc aspartate
Created by admin on Wed Jul 05 23:30:15 UTC 2023 , Edited by admin on Wed Jul 05 23:30:15 UTC 2023
PRIMARY
CAS
36393-20-1
Created by admin on Wed Jul 05 23:30:15 UTC 2023 , Edited by admin on Wed Jul 05 23:30:15 UTC 2023
PRIMARY
NCI_THESAURUS
C1505
Created by admin on Wed Jul 05 23:30:15 UTC 2023 , Edited by admin on Wed Jul 05 23:30:15 UTC 2023
CONCEPT Dietary Supplement
SMS_ID
100000089091
Created by admin on Wed Jul 05 23:30:15 UTC 2023 , Edited by admin on Wed Jul 05 23:30:15 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE