FERROUS DIASPARTATE

First marketed in 1921

Details

Stereochemistry	ABSOLUTE
Molecular Formula	2C4H5NO4.Fe.2H
Molecular Weight	320.034
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H+].[H+].[Fe++].N[C@@H](CC([O-])=O)C([O-])=O.N[C@@H](CC([O-])=O)C([O-])=O

InChI

InChIKey=AQXUAVREDHKIBI-CEOVSRFSSA-L

InChI=1S/2C4H7NO4.Fe/c2*5-2(4(8)9)1-3(6)7;/h2*2H,1,5H2,(H,6,7)(H,8,9);/q;;+2/p-2/t2*2-;/m00./s1

HIDE SMILES / InChI

Molecular Formula	C4H5NO4
Molecular Weight	131.0868
Charge	-2
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	Fe
Molecular Weight	55.845
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H
Molecular Weight	1.0079
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14116934http://www.foodchemadditives.com/products/Ferrous-Lactatehttp://nj.gov/health/eoh/rtkweb/documents/fs/0928.pdfDOI: 10.1021/ja00949a016 Retrived from http://pubs.acs.org/doi/abs/10.1021/ja00949a016https://www.drugs.com/inactive/ferrous-oxide-389.htmlhttp://www.druglead.com/cds/ferrous-iodide.htmlhttp://www.drugfuture.com/chemdata/ferroglycine-sulfate.htmlhttps://www.ncbi.nlm.nih.gov/pubmed/16694502
Curator's Comment: description was created based on several sources, including http://www.minapharm.com/Public/ProductDetails.aspx?ProductCode=FERRO_SANO&langParam=en

Iron(II) gluconate (also known as a ferrous gluconate) is used in the treatment of hypochromic anemia. The real problem of iron therapy is not the theoretical utilization of iron, or the reticulocyte response, or even the daily increase of hemoglobin. These are important only as they indicate the return of the patients' blood to normal in a reasonably short time without undue inconvenience. Most patients suffering from hypochromic anemia respond well to most forms of iron when administered in adequate dosage. For the patients who cannot tolerate the usual iron compounds, it is important to have a medication which is effective and which causes minimum disturbance. Ferrous gluconate is such a medicament.

Originator

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2578
Anemia 68 Sources: http://www.medicatione.com/?c=ing&s=ferrous%20aspartate	Palliative	Not Provided 504	Unknown Approved Use Unknown
Unknown 2578
Hypochromic anemia 36 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16694502	Palliative	Not Provided 504	Unknown Approved Use Unknown
Unknown 2578
Unknown 2578
Unknown 2578
Iron deficiency 80 Sources: http://www.minapharm.com/Public/ProductDetails.aspx?ProductCode=FERRO_SANO&langParam=en	Primary	Approved 8429	Ferro Sanol Duodenal Approved Use Ferro Sanol is an iron substitute in case of latent or manifest iron deficiency with and without development of anaemia.
Unknown 2578

PubMed

Title	Date	PubMed
THE USE OF FERROUS GLUCONATE IN THE TREATMENT OF HYPOCHROMIC ANEMIA.	1937 Jul	16694502
[FERROUS ASPARTATE IN THERAPY].	1964 Jan 1	14116934
Determination of water in ferrous lactate by near infrared reflectance spectroscopy with a fibre-optic probe.	1997 Oct	9408841
Bioleaching of heavy metals from sewage sludge by indigenous iron-oxidizing microorganisms using ammonium ferrous sulfate and ferrous sulfate as energy sources: a comparative study.	2009 Nov 15	19586718
The effect of iron treatment on adhesion molecules in patients with iron deficiency anemia.	2010 Dec	20039148
Tolerability of different oral iron supplements: a systematic review.	2013 Apr	23252877
Effect of abomasal ferrous lactate infusion on phosphorus absorption in lactating dairy cows.	2013 Jul	23660146
A practical and successful desensitization protocol for immediate hypersensitivity reactions to iron salts.	2014	25402762

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 00:23:28 GMT 2023` Edited by `admin` on `Sat Dec 16 00:23:28 GMT 2023`
Record UNII	OC59CUE479
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FERROUS DIASPARTATE

Common Name

English

FERRATE(2-), BIS(L-ASPARTATO(2-)-.KAPPA.N,.KAPPA.O1,.KAPPA.O4)-, HYDROGEN (1:2)

Common Name

English

Code System Code Type Description

PUBCHEM

71586983