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Details

Stereochemistry ACHIRAL
Molecular Formula C5H4N4O3
Molecular Weight 168.1103
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of URIC ACID

SMILES

O=C1NC2=C(N1)C(=O)NC(=O)N2

InChI

InChIKey=LEHOTFFKMJEONL-UHFFFAOYSA-N
InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including: https://www.drugs.com/dict/uric-acid.html | http://www.wikidoc.org/index.php/Uric_acid

Uric acid, generated from the metabolism of purines, has proven and emerging roles in human disease. Humans produce large quantities of uric acid. Excess serum accumulation of uric acid can lead to a type of arthritis known as gout. Hyperuricemia may increase risk factors for cardiovascular disease. High serum uric acid was associated with higher risk of type 2 diabetes and other diseases.

CNS Activity

Originator

Approval Year

2016
495
Targets

Targets

Primary TargetPharmacologyConditionPotency
Urate oxidase (mammals)
3
Target ID: Urate oxidase (mammals)
Substrate
661
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Natural Metabolite
Unknown

Approved Use

Unknown
Diagnostic
Natural Metabolite
Unknown

Approved Use

Unknown
Diagnostic
Natural Metabolite
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Is skeletal muscle damaged by the oxidative stress following anaerobic exercise?
2001
Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors.
2001 Apr 9
Flow-through chemiluminescence sensor using immobilized oxidases for the selective determination of L-glutamate in a flow-injection system.
2001 Aug
Redox reactions of the urate radical/urate couple with the superoxide radical anion, the tryptophan neutral radical and selected flavonoids in neutral aqueous solutions.
2001 Aug
Laryngeal manifestation of gout: a case report of a subglottic gout tophus.
2001 Aug
Biochemical profile of idiopathic uric acid nephrolithiasis.
2001 Aug
Ascorbate dynamics and oxygen consumption during arousal from hibernation in Arctic ground squirrels.
2001 Aug
Reaction of superoxide and nitric oxide with peroxynitrite. Implications for peroxynitrite-mediated oxidation reactions in vivo.
2001 Aug 3
Oxidative stress in lavage fluid of preterm infants at risk of chronic lung disease.
2001 Dec
Allantoin formation and urate and glutathione exchange in human muscle during submaximal exercise.
2001 Dec 1
Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties.
2001 Jan
Lead chelation therapy and urate excretion in patients with chronic renal diseases and gout.
2001 Jul
Low-expression genes induced by nitrogen starvation and subsequent sexual differentiation in Chlamydomonas reinhardtii, isolated by the differential display technique.
2001 Jun
Evidence for alterations in circulating low-molecular-weight antioxidants and increased lipid peroxidation in smokers on hemodialysis.
2001 Jun
Partially reversible renal tubular damage in patients with obstructive jaundice.
2001 Jun
Dehydroascorbic acid and oxidative stress in haemodialysis patients.
2001 Mar
Binding of urate and caffeine to haemocyanin analysed by isothermal titration calorimetry.
2001 Mar
Intracellular pH, intrauterine growth and the insulin resistance syndrome.
2001 Nov
Gout: radiographic findings mimicking infection.
2001 Oct
Molecular and functional characterization of galectin 9 mRNA isoforms in porcine and human cells and tissues.
2001 Sep
Patents

Patents

US3822115
3
US3920400
3
US6753159
3

Sample Use Guides

In Vivo Use Guide
Mice: twice daily with 10 mg per dose for 7 days
Route of Administration: Intraperitoneal
In Vitro Use Guide
Uric acid (5 mg/dL) significantly increased MCP-1 production by rat vascular smooth muscle cells at 3, 6, and 24 hours when compared with that of control media.
Name Type Language
URIC ACID
INCI   MI  
INCI  
Official Name English
URIC ACID [MI]
Common Name English
IDELALISIB METABOLITE M54
Common Name English
PURINE-2,6,8(1H,3H,9H)-TRIONE
Systematic Name English
LITHIC ACID
Common Name English
URICUM ACIDUM
HPUS  
Common Name English
NSC-3975
Code English
7,9-DIHYDRO-1H-PURINE-2,6,8(3H)-TRIONE
Systematic Name English
8-HYDROXYXANTHINE
Systematic Name English
2,6,8-TRIOXYPURINE
Common Name English
URIC ACID [INCI]
Common Name English
URICUM ACIDUM [HPUS]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1916
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
DSLD 3056 (Number of products:1)
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
CFR 21 CFR 862.1775
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
Code System Code Type Description
DRUG BANK
DB08844
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
PRIMARY
ECHA (EC/EINECS)
200-720-7
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
PRIMARY
EVMPD
SUB32801
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
PRIMARY
SMS_ID
100000126333
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
PRIMARY
CAS
69-93-2
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
PRIMARY
EPA CompTox
DTXSID3042508
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
PRIMARY
CHEBI
17775
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
PRIMARY
RXCUI
1427088
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
PRIMARY RxNorm
FDA UNII
268B43MJ25
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
PRIMARY
MESH
D014527
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
PRIMARY
NSC
3975
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
PRIMARY
NCI_THESAURUS
C62652
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
PRIMARY
MERCK INDEX
m11330
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
PRIMARY Merck Index
PUBCHEM
1175
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
PRIMARY
DAILYMED
268B43MJ25
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
PRIMARY
WIKIPEDIA
URIC ACID
Created by admin on Fri Dec 15 15:12:45 UTC 2023 , Edited by admin on Fri Dec 15 15:12:45 UTC 2023
PRIMARY
ACTIVE MOIETY
Structure of URIC ACID
METABOLITE (PARENT)
Structure of Allantoin
PARENT (METABOLITE)
Structure of XANTHINE
PARENT (METABOLITE)
Structure of IDELALISIB
PARENT (METABOLITE)
Structure of NELARABINE
SALT/SOLVATE (PARENT)
Structure of DISODIUM URATE
SALT/SOLVATE (PARENT)
Structure of LITHIUM URATE
SALT/SOLVATE (PARENT)
Structure of SODIUM URATE
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