SODIUM URATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H3N4O3.Na
Molecular Weight	190.0921
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].O=C1NC2=C(N1)C(=O)[N-]C(=O)N2

InChI

InChIKey=NAFSTSRULRIERK-UHFFFAOYSA-M

InChI=1S/C5H4N4O3.Na/c10-3-1-2(7-4(11)6-1)8-5(12)9-3;/h(H4,6,7,8,9,10,11,12);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C5H4N4O3
Molecular Weight	168.1103
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25422986
Curator's Comment: description was created based on several sources, including: https://www.drugs.com/dict/uric-acid.html | http://www.wikidoc.org/index.php/Uric_acid

Uric acid, generated from the metabolism of purines, has proven and emerging roles in human disease. Humans produce large quantities of uric acid. Excess serum accumulation of uric acid can lead to a type of arthritis known as gout. Hyperuricemia may increase risk factors for cardiovascular disease. High serum uric acid was associated with higher risk of type 2 diabetes and other diseases.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Urate oxidase (mammals) 3 Target ID: Urate oxidase (mammals) Sources: https://www.ncbi.nlm.nih.gov/pubmed/2594778	Substrate 661

Conditions

Condition	Modality	Highest Phase	Product
Multiple sclerosis 104 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23528410 https://www.ncbi.nlm.nih.gov/pubmed/11985629	Diagnostic	Natural Metabolite	Unknown Approved Use Unknown
Type 2 diabetes mellitus 259 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17977935	Diagnostic	Natural Metabolite	Unknown Approved Use Unknown
Cardiovascular diseases 71 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25192804	Diagnostic	Natural Metabolite	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Serum cystatin C is a better marker for preeclampsia than serum creatinine or serum urate.	2001	11763416
Comparison of the efficacy of two anti-uric acid diets in dalmatian dogs.	2001	11702341
Is skeletal muscle damaged by the oxidative stress following anaerobic exercise?	2001	11574951
Tumoral calcium pyrophosphate dihydrate crystal deposition disease. A clinicopathologic analysis of five cases.	2001	11482581
Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene.	2001	11474184
Flow-through chemiluminescence sensor using immobilized oxidases for the selective determination of L-glutamate in a flow-injection system.	2001 Aug	11708095
Redox reactions of the urate radical/urate couple with the superoxide radical anion, the tryptophan neutral radical and selected flavonoids in neutral aqueous solutions.	2001 Aug	11697193
Plasma concentrations of alpha-tocopherol and urate in patients with different types of cancer.	2001 Aug	11493368
Laryngeal manifestation of gout: a case report of a subglottic gout tophus.	2001 Aug	11489374
Uric acid or urate nephropathy?	2001 Aug	11479177
Biochemical profile of idiopathic uric acid nephrolithiasis.	2001 Aug	11473659
Self-treatment for gout.	2001 Aug	11461181
Ascorbate dynamics and oxygen consumption during arousal from hibernation in Arctic ground squirrels.	2001 Aug	11448862
Hydrogen peroxide damages the zinc-binding site of zinc-deficient Cu,Zn superoxide dismutase.	2001 Aug 1	11469788
Experimental meningitis in the rat: protection by uric acid at human physiological blood concentrations.	2001 Aug 10	11502281
Photosensitizer initiated attacks on DNA under dry conditions and their inhibition: a DNA archiving issue.	2001 Aug 15	11485843
The cyclooxygenase hydroperoxide product PGG(2) activates synaptic nitric oxide synthase: a possible antioxidant response to membrane lipid peroxidation.	2001 Aug 17	11500026
Recurrent renal stone disease-advances in pathogenesis and clinical management.	2001 Aug 25	11530173
Water-soluble antioxidants in human tears: effect of the collection method.	2001 Dec	11726613
Oxidative stress in lavage fluid of preterm infants at risk of chronic lung disease.	2001 Dec	11704534
Localization and topology of a urate transporter/channel, a galectin, in epithelium-derived cells.	2001 Dec	11698251
Allantoin formation and urate and glutathione exchange in human muscle during submaximal exercise.	2001 Dec 1	11728802
Gouty tenosynovitis of the wrist.	2001 Jul	11482511
Immunological properties of uricase conjugated to neutral soluble polymers.	2001 Jul-Aug	11459455
Low-expression genes induced by nitrogen starvation and subsequent sexual differentiation in Chlamydomonas reinhardtii, isolated by the differential display technique.	2001 Jun	11469597
[Relationship between severity of essential arterial hypertension and the prevalence hyperuricemia].	2001 Jun 23	11459575
Flavonoids and urate antioxidant interplay in plasma oxidative stress.	2001 May	11506190
Modulators of haemocyanin oxygen affinity in the hypoxia- and sulphide-tolerant Baltic isopod Saduria entomon (L.).	2001 Nov	11765978
Intracellular pH, intrauterine growth and the insulin resistance syndrome.	2001 Nov	11722471
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.	2001 Nov	11711505
Nephrocalcinosis in preterm babies.	2001 Nov	11668166
Expression of the urate transporter/channel is developmentally regulated in human kidneys.	2001 Nov	11592946
Respiratory and circulatory compensation to hypoxia in crustaceans.	2001 Nov 15	11718763
Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase.	2001 Nov 16	11700027
Urate oxidase in the prophylaxis or treatment of hyperuricemia: the United States experience.	2001 Oct	11694947
European experience in the treatment of hyperuricemia.	2001 Oct	11694946
Tumor lysis syndrome.	2001 Oct	11694945
Gout: radiographic findings mimicking infection.	2001 Oct	11685479
Recombinant urate oxidase (rasburicase) in the prevention and treatment of malignancy-associated hyperuricemia in pediatric and adult patients: results of a compassionate-use trial.	2001 Oct	11587206
Ozone causes lipid peroxidation but little antioxidant depletion in exercising and nonexercising hamsters.	2001 Oct	11568152
Influence of plasma glutathione levels on radiation mucositis.	2001 Oct 1	11583019
Temperature-sensitive phenotype of Chinese hamster ovary cells defective in PEX5 gene.	2001 Oct 26	11606046
Molecular and functional characterization of galectin 9 mRNA isoforms in porcine and human cells and tissues.	2001 Sep	11698107
Synthesis of ascorbate and urate in the ovary of water buffalo.	2001 Sep	11697122
Concentrations of nucleotides, nucleosides, purine bases, oxypurines, uric acid, and neuron-specific enolase in the cerebrospinal fluid of children with sepsis.	2001 Sep	11575617
A family-based study of metabolic phenotypes in calcium urolithiasis.	2001 Sep	11532110
Suicide inactivation of xanthine oxidoreductase during reduction of inorganic nitrite to nitric oxide.	2001 Sep 1	11513730
Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite.	2002 Jan	11788457
Electrosynthesis of poly-o-diaminobenzene on the Prussian Blue modified electrodes for improvement of hydrogen peroxide transducer characteristics.	2002 Jan	11786361
Superoxide mediates shock wave induction of ERK-dependent osteogenic transcription factor (CBFA1) and mesenchymal cell differentiation toward osteoprogenitors.	2002 Mar 29	11784711

Patents

Sample Use Guides

In Vivo Use Guide

Mice: twice daily with 10 mg per dose for 7 days

Route of Administration: Intraperitoneal

In Vitro Use Guide

Uric acid (5 mg/dL) significantly increased MCP-1 production by rat vascular smooth muscle cells at 3, 6, and 24 hours when compared with that of control media.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:19:22 UTC 2023` Edited by `admin` on `Fri Dec 15 15:19:22 UTC 2023`
Record UNII	WA4Q622EWK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SODIUM URATE

Common Name

English

1H-PURINE-2,6,8(3H)-TRIONE, 7,9-DIHYDRO-, SODIUM SALT (1:1)

Systematic Name

English

MONOSODIUM URATE

Common Name

English

URIC ACID, MONOSODIUM SALT

Common Name

English

Classification Tree Code System Code

LOINC

54437-9