Details
Stereochemistry | ACHIRAL |
Molecular Formula | C5H4N4O3 |
Molecular Weight | 168.1103 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C1NC2=C(N1)C(=O)NC(=O)N2
InChI
InChIKey=LEHOTFFKMJEONL-UHFFFAOYSA-N
InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)
Molecular Formula | C5H4N4O3 |
Molecular Weight | 168.1103 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/25422986Curator's Comment: description was created based on several sources, including:
https://www.drugs.com/dict/uric-acid.html | http://www.wikidoc.org/index.php/Uric_acid
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25422986
Curator's Comment: description was created based on several sources, including:
https://www.drugs.com/dict/uric-acid.html | http://www.wikidoc.org/index.php/Uric_acid
Uric acid, generated from the metabolism of purines, has proven and emerging roles in human disease. Humans produce large quantities of uric acid. Excess serum accumulation of uric acid can lead to a type of arthritis known as gout. Hyperuricemia may increase risk factors for cardiovascular disease. High serum uric acid was associated with higher risk of type 2 diabetes and other diseases.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: Urate oxidase (mammals) Sources: https://www.ncbi.nlm.nih.gov/pubmed/2594778 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Diagnostic | Unknown Approved UseUnknown |
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Diagnostic | Unknown Approved UseUnknown |
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Diagnostic | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Copper and zinc concentrations and the activities of ceruloplasmin and superoxide dismutase in atherosclerosis obliterans. | 2000 Jan |
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Serum cystatin C is a better marker for preeclampsia than serum creatinine or serum urate. | 2001 |
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Comparison of the efficacy of two anti-uric acid diets in dalmatian dogs. | 2001 |
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Is skeletal muscle damaged by the oxidative stress following anaerobic exercise? | 2001 |
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Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. | 2001 |
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Inflammatory microcrystals induce murine macrophage survival and DNA synthesis. | 2001 |
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Flow-through chemiluminescence sensor using immobilized oxidases for the selective determination of L-glutamate in a flow-injection system. | 2001 Aug |
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Redox reactions of the urate radical/urate couple with the superoxide radical anion, the tryptophan neutral radical and selected flavonoids in neutral aqueous solutions. | 2001 Aug |
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Hydrogen peroxide damages the zinc-binding site of zinc-deficient Cu,Zn superoxide dismutase. | 2001 Aug 1 |
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Photosensitizer initiated attacks on DNA under dry conditions and their inhibition: a DNA archiving issue. | 2001 Aug 15 |
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Recurrent renal stone disease-advances in pathogenesis and clinical management. | 2001 Aug 25 |
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Water-soluble antioxidants in human tears: effect of the collection method. | 2001 Dec |
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Oxidative stress in lavage fluid of preterm infants at risk of chronic lung disease. | 2001 Dec |
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Localization and topology of a urate transporter/channel, a galectin, in epithelium-derived cells. | 2001 Dec |
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Allantoin formation and urate and glutathione exchange in human muscle during submaximal exercise. | 2001 Dec 1 |
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Difficult gout and new approaches for control of hyperuricemia in the allopurinol-allergic patient. | 2001 Feb |
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Recombinant urate oxidase for the prophylaxis or treatment of hyperuricemia in patients With leukemia or lymphoma. | 2001 Feb 1 |
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Efficacy and safety of desensitization to allopurinol following cutaneous reactions. | 2001 Jan |
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Role of exercise and ascorbate on plasma antioxidant capacity in thoroughbred race horses. | 2001 Jan |
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The role of uric acid in protection against peroxynitrite-mediated pathology. | 2001 Jan |
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The characteristics of nucleobase transport and metabolism by the perfused sheep choroid plexus. | 2001 Jan 5 |
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Immunological properties of uricase conjugated to neutral soluble polymers. | 2001 Jul-Aug |
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Low-expression genes induced by nitrogen starvation and subsequent sexual differentiation in Chlamydomonas reinhardtii, isolated by the differential display technique. | 2001 Jun |
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Pathways for urea production during early life of an air-breathing teleost, the African catfish Clarias gariepinus Burchell. | 2001 Jun |
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Renal regulation of plasma total antioxidant capacity. | 2001 Jun |
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Cystine calculi in children: the results of a metabolic evaluation and response to medical therapy. | 2001 Jun |
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[Relationship between severity of essential arterial hypertension and the prevalence hyperuricemia]. | 2001 Jun 23 |
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Treatment of chronic gout. Can we determine when urate stores are depleted enough to prevent attacks of gout? | 2001 Mar |
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Contribution of peroxynitrite to the beneficial effects of preconditioning on ischaemia-induced arrhythmias in rat isolated hearts. | 2001 Mar |
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Dehydroascorbic acid and oxidative stress in haemodialysis patients. | 2001 Mar |
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Binding of urate and caffeine to haemocyanin analysed by isothermal titration calorimetry. | 2001 Mar |
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Flavonoids and urate antioxidant interplay in plasma oxidative stress. | 2001 May |
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Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase. | 2001 May |
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Marked elevation in cortical urate and xanthine oxidoreductase activity in experimental bacterial meningitis. | 2001 May 11 |
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A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis. | 2001 May 15 |
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Modulators of haemocyanin oxygen affinity in the hypoxia- and sulphide-tolerant Baltic isopod Saduria entomon (L.). | 2001 Nov |
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Intracellular pH, intrauterine growth and the insulin resistance syndrome. | 2001 Nov |
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Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. | 2001 Nov |
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Respiratory and circulatory compensation to hypoxia in crustaceans. | 2001 Nov 15 |
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Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase. | 2001 Nov 16 |
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Urate oxidase in the prophylaxis or treatment of hyperuricemia: the United States experience. | 2001 Oct |
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European experience in the treatment of hyperuricemia. | 2001 Oct |
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Ozone causes lipid peroxidation but little antioxidant depletion in exercising and nonexercising hamsters. | 2001 Oct |
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Molecular and functional characterization of galectin 9 mRNA isoforms in porcine and human cells and tissues. | 2001 Sep |
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Synthesis of ascorbate and urate in the ovary of water buffalo. | 2001 Sep |
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Concentrations of nucleotides, nucleosides, purine bases, oxypurines, uric acid, and neuron-specific enolase in the cerebrospinal fluid of children with sepsis. | 2001 Sep |
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A family-based study of metabolic phenotypes in calcium urolithiasis. | 2001 Sep |
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Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite. | 2002 Jan |
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Electrosynthesis of poly-o-diaminobenzene on the Prussian Blue modified electrodes for improvement of hydrogen peroxide transducer characteristics. | 2002 Jan |
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Superoxide mediates shock wave induction of ERK-dependent osteogenic transcription factor (CBFA1) and mesenchymal cell differentiation toward osteoprogenitors. | 2002 Mar 29 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9435251
Mice: twice daily with 10 mg per dose for 7 days
Route of Administration:
Intraperitoneal
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12743010
Uric acid (5 mg/dL) significantly increased MCP-1 production by rat vascular smooth muscle cells at 3, 6, and 24 hours when compared with that of control media.
Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Jul 05 22:44:16 UTC 2023
by
admin
on
Wed Jul 05 22:44:16 UTC 2023
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Record UNII |
268B43MJ25
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Record Status |
Validated (UNII)
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NCI_THESAURUS |
C1916
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DSLD |
3056 (Number of products:1)
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CFR |
21 CFR 862.1775
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268B43MJ25
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D014527
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1175
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268B43MJ25
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URIC ACID
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Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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TARGET -> SUBSTRATE |
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TRANSPORTER -> SUBSTRATE |
In the human kidney, urate is transported (reabsorbed) via URAT1 across the apical membrane of proximal tubule cells, in exchange for anions being transported back into the tubule lumen to maintain electrical balance.
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SALT/SOLVATE -> PARENT |
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PARENT -> METABOLITE |
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PARENT -> METABOLITE | |||
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PARENT -> METABOLITE |
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METABOLITE -> PARENT |
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ACTIVE MOIETY |