U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C5H4N4O3
Molecular Weight 168.1103
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of URIC ACID

SMILES

O=C1NC2=C(N1)C(=O)NC(=O)N2

InChI

InChIKey=LEHOTFFKMJEONL-UHFFFAOYSA-N
InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)

HIDE SMILES / InChI

Molecular Formula C5H4N4O3
Molecular Weight 168.1103
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including: https://www.drugs.com/dict/uric-acid.html | http://www.wikidoc.org/index.php/Uric_acid

Uric acid, generated from the metabolism of purines, has proven and emerging roles in human disease. Humans produce large quantities of uric acid. Excess serum accumulation of uric acid can lead to a type of arthritis known as gout. Hyperuricemia may increase risk factors for cardiovascular disease. High serum uric acid was associated with higher risk of type 2 diabetes and other diseases.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Urate oxidase (mammals)
Conditions

Conditions

PubMed

PubMed

TitleDatePubMed
Is skeletal muscle damaged by the oxidative stress following anaerobic exercise?
2001
Tumoral calcium pyrophosphate dihydrate crystal deposition disease. A clinicopathologic analysis of five cases.
2001
Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene.
2001
Influence quantities and uncertainty of measurement.
2001
Plasma concentrations of alpha-tocopherol and urate in patients with different types of cancer.
2001 Aug
Uric acid or urate nephropathy?
2001 Aug
Biochemical profile of idiopathic uric acid nephrolithiasis.
2001 Aug
Self-treatment for gout.
2001 Aug
Ascorbate dynamics and oxygen consumption during arousal from hibernation in Arctic ground squirrels.
2001 Aug
The cyclooxygenase hydroperoxide product PGG(2) activates synaptic nitric oxide synthase: a possible antioxidant response to membrane lipid peroxidation.
2001 Aug 17
Reaction of superoxide and nitric oxide with peroxynitrite. Implications for peroxynitrite-mediated oxidation reactions in vivo.
2001 Aug 3
Localization and topology of a urate transporter/channel, a galectin, in epithelium-derived cells.
2001 Dec
Recombinant urate oxidase for the prophylaxis or treatment of hyperuricemia in patients With leukemia or lymphoma.
2001 Feb 1
The effect of trimethoprim on potassium and uric acid metabolism in normal human subjects.
2001 Jan
Role of exercise and ascorbate on plasma antioxidant capacity in thoroughbred race horses.
2001 Jan
Role of aminothiols as a component of the plasma antioxidant system and relevance to homocysteine-mediated vascular disease.
2001 Jan
Low-expression genes induced by nitrogen starvation and subsequent sexual differentiation in Chlamydomonas reinhardtii, isolated by the differential display technique.
2001 Jun
Treatment of chronic gout. Can we determine when urate stores are depleted enough to prevent attacks of gout?
2001 Mar
Uric acid and cardiovascular disease: a renal-cardiac relationship?
2001 May
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.
2001 May
Expression of the urate transporter/channel is developmentally regulated in human kidneys.
2001 Nov
Respiratory and circulatory compensation to hypoxia in crustaceans.
2001 Nov 15
Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase.
2001 Nov 16
Temperature-sensitive phenotype of Chinese hamster ovary cells defective in PEX5 gene.
2001 Oct 26
Concentrations of nucleotides, nucleosides, purine bases, oxypurines, uric acid, and neuron-specific enolase in the cerebrospinal fluid of children with sepsis.
2001 Sep
A family-based study of metabolic phenotypes in calcium urolithiasis.
2001 Sep
Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite.
2002 Jan
Superoxide mediates shock wave induction of ERK-dependent osteogenic transcription factor (CBFA1) and mesenchymal cell differentiation toward osteoprogenitors.
2002 Mar 29
Patents

Sample Use Guides

Mice: twice daily with 10 mg per dose for 7 days
Route of Administration: Intraperitoneal
Uric acid (5 mg/dL) significantly increased MCP-1 production by rat vascular smooth muscle cells at 3, 6, and 24 hours when compared with that of control media.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:12:45 GMT 2023
Edited
by admin
on Fri Dec 15 15:12:45 GMT 2023
Record UNII
268B43MJ25
Record Status Validated (UNII)
Record Version
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Name Type Language
URIC ACID
INCI   MI  
INCI  
Official Name English
URIC ACID [MI]
Common Name English
IDELALISIB METABOLITE M54
Common Name English
PURINE-2,6,8(1H,3H,9H)-TRIONE
Systematic Name English
LITHIC ACID
Common Name English
URICUM ACIDUM
HPUS  
Common Name English
NSC-3975
Code English
7,9-DIHYDRO-1H-PURINE-2,6,8(3H)-TRIONE
Systematic Name English
8-HYDROXYXANTHINE
Systematic Name English
2,6,8-TRIOXYPURINE
Common Name English
URIC ACID [INCI]
Common Name English
URICUM ACIDUM [HPUS]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1916
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
DSLD 3056 (Number of products:1)
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
CFR 21 CFR 862.1775
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
Code System Code Type Description
DRUG BANK
DB08844
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-720-7
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
PRIMARY
EVMPD
SUB32801
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
PRIMARY
SMS_ID
100000126333
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
PRIMARY
CAS
69-93-2
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
PRIMARY
EPA CompTox
DTXSID3042508
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
PRIMARY
CHEBI
17775
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
PRIMARY
RXCUI
1427088
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
PRIMARY RxNorm
FDA UNII
268B43MJ25
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
PRIMARY
MESH
D014527
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
PRIMARY
NSC
3975
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
PRIMARY
NCI_THESAURUS
C62652
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
PRIMARY
MERCK INDEX
m11330
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
PRIMARY Merck Index
PUBCHEM
1175
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
PRIMARY
DAILYMED
268B43MJ25
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
PRIMARY
WIKIPEDIA
URIC ACID
Created by admin on Fri Dec 15 15:12:45 GMT 2023 , Edited by admin on Fri Dec 15 15:12:45 GMT 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
TARGET -> SUBSTRATE
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
TRANSPORTER -> SUBSTRATE
In the human kidney, urate is transported (reabsorbed) via URAT1 across the apical membrane of proximal tubule cells, in exchange for anions being transported back into the tubule lumen to maintain electrical balance.
Related Record Type Details
PARENT -> METABOLITE
PARENT -> METABOLITE
PARENT -> METABOLITE
METABOLITE -> PARENT
Related Record Type Details
ACTIVE MOIETY