U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C5H4N4O3
Molecular Weight 168.1103
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of URIC ACID

SMILES

O=C1NC2=C(N1)C(=O)NC(=O)N2

InChI

InChIKey=LEHOTFFKMJEONL-UHFFFAOYSA-N
InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)

HIDE SMILES / InChI

Molecular Formula C5H4N4O3
Molecular Weight 168.1103
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including: https://www.drugs.com/dict/uric-acid.html | http://www.wikidoc.org/index.php/Uric_acid

Uric acid, generated from the metabolism of purines, has proven and emerging roles in human disease. Humans produce large quantities of uric acid. Excess serum accumulation of uric acid can lead to a type of arthritis known as gout. Hyperuricemia may increase risk factors for cardiovascular disease. High serum uric acid was associated with higher risk of type 2 diabetes and other diseases.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Urate oxidase (mammals)
Conditions

Conditions

PubMed

PubMed

TitleDatePubMed
Copper and zinc concentrations and the activities of ceruloplasmin and superoxide dismutase in atherosclerosis obliterans.
2000 Jan
Serum cystatin C is a better marker for preeclampsia than serum creatinine or serum urate.
2001
Comparison of the efficacy of two anti-uric acid diets in dalmatian dogs.
2001
Is skeletal muscle damaged by the oxidative stress following anaerobic exercise?
2001
Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene.
2001
Inflammatory microcrystals induce murine macrophage survival and DNA synthesis.
2001
Flow-through chemiluminescence sensor using immobilized oxidases for the selective determination of L-glutamate in a flow-injection system.
2001 Aug
Redox reactions of the urate radical/urate couple with the superoxide radical anion, the tryptophan neutral radical and selected flavonoids in neutral aqueous solutions.
2001 Aug
Hydrogen peroxide damages the zinc-binding site of zinc-deficient Cu,Zn superoxide dismutase.
2001 Aug 1
Photosensitizer initiated attacks on DNA under dry conditions and their inhibition: a DNA archiving issue.
2001 Aug 15
Recurrent renal stone disease-advances in pathogenesis and clinical management.
2001 Aug 25
Water-soluble antioxidants in human tears: effect of the collection method.
2001 Dec
Oxidative stress in lavage fluid of preterm infants at risk of chronic lung disease.
2001 Dec
Localization and topology of a urate transporter/channel, a galectin, in epithelium-derived cells.
2001 Dec
Allantoin formation and urate and glutathione exchange in human muscle during submaximal exercise.
2001 Dec 1
Difficult gout and new approaches for control of hyperuricemia in the allopurinol-allergic patient.
2001 Feb
Recombinant urate oxidase for the prophylaxis or treatment of hyperuricemia in patients With leukemia or lymphoma.
2001 Feb 1
Efficacy and safety of desensitization to allopurinol following cutaneous reactions.
2001 Jan
Role of exercise and ascorbate on plasma antioxidant capacity in thoroughbred race horses.
2001 Jan
The role of uric acid in protection against peroxynitrite-mediated pathology.
2001 Jan
The characteristics of nucleobase transport and metabolism by the perfused sheep choroid plexus.
2001 Jan 5
Immunological properties of uricase conjugated to neutral soluble polymers.
2001 Jul-Aug
Low-expression genes induced by nitrogen starvation and subsequent sexual differentiation in Chlamydomonas reinhardtii, isolated by the differential display technique.
2001 Jun
Pathways for urea production during early life of an air-breathing teleost, the African catfish Clarias gariepinus Burchell.
2001 Jun
Renal regulation of plasma total antioxidant capacity.
2001 Jun
Cystine calculi in children: the results of a metabolic evaluation and response to medical therapy.
2001 Jun
[Relationship between severity of essential arterial hypertension and the prevalence hyperuricemia].
2001 Jun 23
Treatment of chronic gout. Can we determine when urate stores are depleted enough to prevent attacks of gout?
2001 Mar
Contribution of peroxynitrite to the beneficial effects of preconditioning on ischaemia-induced arrhythmias in rat isolated hearts.
2001 Mar
Dehydroascorbic acid and oxidative stress in haemodialysis patients.
2001 Mar
Binding of urate and caffeine to haemocyanin analysed by isothermal titration calorimetry.
2001 Mar
Flavonoids and urate antioxidant interplay in plasma oxidative stress.
2001 May
Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase.
2001 May
Marked elevation in cortical urate and xanthine oxidoreductase activity in experimental bacterial meningitis.
2001 May 11
A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis.
2001 May 15
Modulators of haemocyanin oxygen affinity in the hypoxia- and sulphide-tolerant Baltic isopod Saduria entomon (L.).
2001 Nov
Intracellular pH, intrauterine growth and the insulin resistance syndrome.
2001 Nov
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.
2001 Nov
Respiratory and circulatory compensation to hypoxia in crustaceans.
2001 Nov 15
Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase.
2001 Nov 16
Urate oxidase in the prophylaxis or treatment of hyperuricemia: the United States experience.
2001 Oct
European experience in the treatment of hyperuricemia.
2001 Oct
Ozone causes lipid peroxidation but little antioxidant depletion in exercising and nonexercising hamsters.
2001 Oct
Molecular and functional characterization of galectin 9 mRNA isoforms in porcine and human cells and tissues.
2001 Sep
Synthesis of ascorbate and urate in the ovary of water buffalo.
2001 Sep
Concentrations of nucleotides, nucleosides, purine bases, oxypurines, uric acid, and neuron-specific enolase in the cerebrospinal fluid of children with sepsis.
2001 Sep
A family-based study of metabolic phenotypes in calcium urolithiasis.
2001 Sep
Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite.
2002 Jan
Electrosynthesis of poly-o-diaminobenzene on the Prussian Blue modified electrodes for improvement of hydrogen peroxide transducer characteristics.
2002 Jan
Superoxide mediates shock wave induction of ERK-dependent osteogenic transcription factor (CBFA1) and mesenchymal cell differentiation toward osteoprogenitors.
2002 Mar 29
Patents

Sample Use Guides

Mice: twice daily with 10 mg per dose for 7 days
Route of Administration: Intraperitoneal
Uric acid (5 mg/dL) significantly increased MCP-1 production by rat vascular smooth muscle cells at 3, 6, and 24 hours when compared with that of control media.
Substance Class Chemical
Created
by admin
on Wed Jul 05 22:44:16 UTC 2023
Edited
by admin
on Wed Jul 05 22:44:16 UTC 2023
Record UNII
268B43MJ25
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
URIC ACID
INCI   MI  
INCI  
Official Name English
URIC ACID [MI]
Common Name English
IDELALISIB METABOLITE M54
Common Name English
PURINE-2,6,8(1H,3H,9H)-TRIONE
Systematic Name English
LITHIC ACID
Common Name English
URICUM ACIDUM
HPUS  
Common Name English
NSC-3975
Code English
7,9-DIHYDRO-1H-PURINE-2,6,8(3H)-TRIONE
Systematic Name English
8-HYDROXYXANTHINE
Systematic Name English
2,6,8-TRIOXYPURINE
Common Name English
URIC ACID [INCI]
Common Name English
URICUM ACIDUM [HPUS]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1916
Created by admin on Wed Jul 05 22:44:17 UTC 2023 , Edited by admin on Wed Jul 05 22:44:17 UTC 2023
DSLD 3056 (Number of products:1)
Created by admin on Wed Jul 05 22:44:16 UTC 2023 , Edited by admin on Wed Jul 05 22:44:16 UTC 2023
CFR 21 CFR 862.1775
Created by admin on Wed Jul 05 22:44:16 UTC 2023 , Edited by admin on Wed Jul 05 22:44:16 UTC 2023
Code System Code Type Description
DRUG BANK
DB08844
Created by admin on Wed Jul 05 22:44:16 UTC 2023 , Edited by admin on Wed Jul 05 22:44:16 UTC 2023
PRIMARY
ECHA (EC/EINECS)
200-720-7
Created by admin on Wed Jul 05 22:44:16 UTC 2023 , Edited by admin on Wed Jul 05 22:44:16 UTC 2023
PRIMARY
EVMPD
SUB32801
Created by admin on Wed Jul 05 22:44:16 UTC 2023 , Edited by admin on Wed Jul 05 22:44:16 UTC 2023
PRIMARY
SMS_ID
100000126333
Created by admin on Wed Jul 05 22:44:17 UTC 2023 , Edited by admin on Wed Jul 05 22:44:17 UTC 2023
PRIMARY
CAS
69-93-2
Created by admin on Wed Jul 05 22:44:16 UTC 2023 , Edited by admin on Wed Jul 05 22:44:16 UTC 2023
PRIMARY
EPA CompTox
DTXSID3042508
Created by admin on Wed Jul 05 22:44:16 UTC 2023 , Edited by admin on Wed Jul 05 22:44:16 UTC 2023
PRIMARY
CHEBI
17775
Created by admin on Wed Jul 05 22:44:16 UTC 2023 , Edited by admin on Wed Jul 05 22:44:16 UTC 2023
PRIMARY
RXCUI
1427088
Created by admin on Wed Jul 05 22:44:17 UTC 2023 , Edited by admin on Wed Jul 05 22:44:17 UTC 2023
PRIMARY RxNorm
FDA UNII
268B43MJ25
Created by admin on Wed Jul 05 22:44:17 UTC 2023 , Edited by admin on Wed Jul 05 22:44:17 UTC 2023
PRIMARY
MESH
D014527
Created by admin on Wed Jul 05 22:44:17 UTC 2023 , Edited by admin on Wed Jul 05 22:44:17 UTC 2023
PRIMARY
NSC
3975
Created by admin on Wed Jul 05 22:44:17 UTC 2023 , Edited by admin on Wed Jul 05 22:44:17 UTC 2023
PRIMARY
NCI_THESAURUS
C62652
Created by admin on Wed Jul 05 22:44:17 UTC 2023 , Edited by admin on Wed Jul 05 22:44:17 UTC 2023
PRIMARY
MERCK INDEX
M11330
Created by admin on Wed Jul 05 22:44:17 UTC 2023 , Edited by admin on Wed Jul 05 22:44:17 UTC 2023
PRIMARY Merck Index
PUBCHEM
1175
Created by admin on Wed Jul 05 22:44:17 UTC 2023 , Edited by admin on Wed Jul 05 22:44:17 UTC 2023
PRIMARY
DAILYMED
268B43MJ25
Created by admin on Wed Jul 05 22:44:16 UTC 2023 , Edited by admin on Wed Jul 05 22:44:16 UTC 2023
PRIMARY
WIKIPEDIA
URIC ACID
Created by admin on Wed Jul 05 22:44:17 UTC 2023 , Edited by admin on Wed Jul 05 22:44:17 UTC 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
TARGET -> SUBSTRATE
TRANSPORTER -> SUBSTRATE
In the human kidney, urate is transported (reabsorbed) via URAT1 across the apical membrane of proximal tubule cells, in exchange for anions being transported back into the tubule lumen to maintain electrical balance.
SALT/SOLVATE -> PARENT
Related Record Type Details
PARENT -> METABOLITE
PARENT -> METABOLITE
PARENT -> METABOLITE
METABOLITE -> PARENT
Related Record Type Details
ACTIVE MOIETY