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Details

Stereochemistry ACHIRAL
Molecular Formula C5H4N4O3
Molecular Weight 168.1103
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of URIC ACID

SMILES

O=C1NC2=C(N1)C(=O)NC(=O)N2

InChI

InChIKey=LEHOTFFKMJEONL-UHFFFAOYSA-N
InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)

HIDE SMILES / InChI

Molecular Formula C5H4N4O3
Molecular Weight 168.1103
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including: https://www.drugs.com/dict/uric-acid.html | http://www.wikidoc.org/index.php/Uric_acid

Uric acid, generated from the metabolism of purines, has proven and emerging roles in human disease. Humans produce large quantities of uric acid. Excess serum accumulation of uric acid can lead to a type of arthritis known as gout. Hyperuricemia may increase risk factors for cardiovascular disease. High serum uric acid was associated with higher risk of type 2 diabetes and other diseases.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Urate oxidase (mammals)
Conditions

Conditions

PubMed

PubMed

TitleDatePubMed
Serum cystatin C is a better marker for preeclampsia than serum creatinine or serum urate.
2001
Comparison of the efficacy of two anti-uric acid diets in dalmatian dogs.
2001
Is skeletal muscle damaged by the oxidative stress following anaerobic exercise?
2001
Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene.
2001
Prostaglandin inhibition by intraperitoneal indomethacin has no effect on peritoneal permeability during stable CAPD.
2001 Apr
The potential role of adenosine in the pathophysiology of the insulin resistance syndrome.
2001 Apr
Hyperuricemia exacerbates chronic cyclosporine nephropathy.
2001 Apr 15
Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors.
2001 Apr 9
Flow-through chemiluminescence sensor using immobilized oxidases for the selective determination of L-glutamate in a flow-injection system.
2001 Aug
Plasma concentrations of alpha-tocopherol and urate in patients with different types of cancer.
2001 Aug
Biochemical profile of idiopathic uric acid nephrolithiasis.
2001 Aug
Reaction of superoxide and nitric oxide with peroxynitrite. Implications for peroxynitrite-mediated oxidation reactions in vivo.
2001 Aug 3
Water-soluble antioxidants in human tears: effect of the collection method.
2001 Dec
Oxidative stress in lavage fluid of preterm infants at risk of chronic lung disease.
2001 Dec
Localization and topology of a urate transporter/channel, a galectin, in epithelium-derived cells.
2001 Dec
Allantoin formation and urate and glutathione exchange in human muscle during submaximal exercise.
2001 Dec 1
Inhibition of peroxynitrite-induced dityrosine formation with oxidized and reduced thiols, nitric oxide donors, and purine derivatives.
2001 Feb
Difficult gout and new approaches for control of hyperuricemia in the allopurinol-allergic patient.
2001 Feb
Antioxidants and protein carbonyls in bronchoalveolar lavage fluid of children: normal data.
2001 Feb
Recombinant urate oxidase for the prophylaxis or treatment of hyperuricemia in patients With leukemia or lymphoma.
2001 Feb 1
Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties.
2001 Jan
Role of exercise and ascorbate on plasma antioxidant capacity in thoroughbred race horses.
2001 Jan
The characteristics of nucleobase transport and metabolism by the perfused sheep choroid plexus.
2001 Jan 5
Hypophosphataemia in the metabolic syndrome. Gender differences in body weight and blood glucose.
2001 Jun
Partially reversible renal tubular damage in patients with obstructive jaundice.
2001 Jun
Ascorbate acid concentration in airways lining fluid from infants who develop chronic lung disease of prematurity.
2001 Mar
Contribution of peroxynitrite to the beneficial effects of preconditioning on ischaemia-induced arrhythmias in rat isolated hearts.
2001 Mar
Ureteropelvic junction obstruction and coexisting renal calculi in children: role of metabolic abnormalities.
2001 Mar
Binding of urate and caffeine to haemocyanin analysed by isothermal titration calorimetry.
2001 Mar
Red wine polyphenols, in the absence of alcohol, reduce lipid peroxidative stress in smoking subjects.
2001 Mar 15
Flavonoids and urate antioxidant interplay in plasma oxidative stress.
2001 May
Functional reconstitution, membrane targeting, genomic structure, and chromosomal localization of a human urate transporter.
2001 May
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.
2001 May
Modulators of haemocyanin oxygen affinity in the hypoxia- and sulphide-tolerant Baltic isopod Saduria entomon (L.).
2001 Nov
Intracellular pH, intrauterine growth and the insulin resistance syndrome.
2001 Nov
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.
2001 Nov
Expression of the urate transporter/channel is developmentally regulated in human kidneys.
2001 Nov
Respiratory and circulatory compensation to hypoxia in crustaceans.
2001 Nov 15
Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase.
2001 Nov 16
Tumor lysis syndrome.
2001 Oct
Gout: radiographic findings mimicking infection.
2001 Oct
Recombinant urate oxidase (rasburicase) in the prevention and treatment of malignancy-associated hyperuricemia in pediatric and adult patients: results of a compassionate-use trial.
2001 Oct
Ozone causes lipid peroxidation but little antioxidant depletion in exercising and nonexercising hamsters.
2001 Oct
Temperature-sensitive phenotype of Chinese hamster ovary cells defective in PEX5 gene.
2001 Oct 26
Molecular and functional characterization of galectin 9 mRNA isoforms in porcine and human cells and tissues.
2001 Sep
Concentrations of nucleotides, nucleosides, purine bases, oxypurines, uric acid, and neuron-specific enolase in the cerebrospinal fluid of children with sepsis.
2001 Sep
A family-based study of metabolic phenotypes in calcium urolithiasis.
2001 Sep
Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite.
2002 Jan
Electrosynthesis of poly-o-diaminobenzene on the Prussian Blue modified electrodes for improvement of hydrogen peroxide transducer characteristics.
2002 Jan
Superoxide mediates shock wave induction of ERK-dependent osteogenic transcription factor (CBFA1) and mesenchymal cell differentiation toward osteoprogenitors.
2002 Mar 29
Patents

Sample Use Guides

Mice: twice daily with 10 mg per dose for 7 days
Route of Administration: Intraperitoneal
Uric acid (5 mg/dL) significantly increased MCP-1 production by rat vascular smooth muscle cells at 3, 6, and 24 hours when compared with that of control media.
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:50:20 GMT 2025
Edited
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on Mon Mar 31 17:50:20 GMT 2025
Record UNII
268B43MJ25
Record Status Validated (UNII)
Record Version
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Name Type Language
URICUM ACIDUM
HPUS  
Preferred Name English
URIC ACID
INCI   MI  
INCI  
Official Name English
URIC ACID [MI]
Common Name English
IDELALISIB METABOLITE M54
Common Name English
PURINE-2,6,8(1H,3H,9H)-TRIONE
Systematic Name English
LITHIC ACID
Common Name English
NSC-3975
Code English
7,9-DIHYDRO-1H-PURINE-2,6,8(3H)-TRIONE
Systematic Name English
8-HYDROXYXANTHINE
Systematic Name English
2,6,8-TRIOXYPURINE
Common Name English
URICUM ACIDUM [HPUS]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1916
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
DSLD 3056 (Number of products:1)
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
CFR 21 CFR 862.1775
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
Code System Code Type Description
DRUG BANK
DB08844
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
PRIMARY
ECHA (EC/EINECS)
200-720-7
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
PRIMARY
EVMPD
SUB32801
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
PRIMARY
SMS_ID
100000126333
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
PRIMARY
CAS
69-93-2
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
PRIMARY
EPA CompTox
DTXSID3042508
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
PRIMARY
CHEBI
17775
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
PRIMARY
RXCUI
1427088
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
PRIMARY RxNorm
FDA UNII
268B43MJ25
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
PRIMARY
MESH
D014527
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
PRIMARY
NSC
3975
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
PRIMARY
NCI_THESAURUS
C62652
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
PRIMARY
MERCK INDEX
m11330
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
PRIMARY Merck Index
PUBCHEM
1175
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
PRIMARY
DAILYMED
268B43MJ25
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
PRIMARY
WIKIPEDIA
URIC ACID
Created by admin on Mon Mar 31 17:50:21 GMT 2025 , Edited by admin on Mon Mar 31 17:50:21 GMT 2025
PRIMARY
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