DISODIUM URATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H2N4O3.2Na
Molecular Weight	212.0739
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].O=C1NC2=C(NC(=O)[N-]C2=O)[N-]1

InChI

InChIKey=JNNYOCABZPYQDB-UHFFFAOYSA-L

InChI=1S/C5H4N4O3.2Na/c10-3-1-2(7-4(11)6-1)8-5(12)9-3;;/h(H4,6,7,8,9,10,11,12);;/q;2*+1/p-2

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C5H4N4O3
Molecular Weight	168.1103
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25422986
Curator's Comment: description was created based on several sources, including: https://www.drugs.com/dict/uric-acid.html | http://www.wikidoc.org/index.php/Uric_acid

Uric acid, generated from the metabolism of purines, has proven and emerging roles in human disease. Humans produce large quantities of uric acid. Excess serum accumulation of uric acid can lead to a type of arthritis known as gout. Hyperuricemia may increase risk factors for cardiovascular disease. High serum uric acid was associated with higher risk of type 2 diabetes and other diseases.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Urate oxidase (mammals) 4 Target ID: Urate oxidase (mammals) Sources: https://www.ncbi.nlm.nih.gov/pubmed/2594778	Substrate 661

Conditions

Condition	Modality	Highest Phase	Product
Multiple sclerosis 107 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23528410 https://www.ncbi.nlm.nih.gov/pubmed/11985629	Diagnostic	Natural Metabolite	Unknown Approved Use Unknown
Type 2 diabetes mellitus 262 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17977935	Diagnostic	Natural Metabolite	Unknown Approved Use Unknown
Cardiovascular diseases 72 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25192804	Diagnostic	Natural Metabolite	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Serum cystatin C is a better marker for preeclampsia than serum creatinine or serum urate.	2001	11763416
The potential role of adenosine in the pathophysiology of the insulin resistance syndrome.	2001 Apr	11254897
Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors.	2001 Apr 9	11294382
Biochemical profile of idiopathic uric acid nephrolithiasis.	2001 Aug	11473659
Difficult gout and new approaches for control of hyperuricemia in the allopurinol-allergic patient.	2001 Feb	11177768
A disease resembling inclusion body disease of boid snakes in captive palm vipers (Bothriechis marchi).	2001 Jan	11243371
Risk factors for coronary heart disease in obese non-diabetic subjects.	2001 Jul	11443504
Reduction of organic nitrates catalysed by xanthine oxidoreductase under anaerobic conditions.	2001 Jul 2	11420146
Hyperuricemia and renal function.	2001 Jun	11353569
Vascular changes in cyclosporine A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats on high-sodium diet.	2001 Mar	11321510
Ureteropelvic junction obstruction and coexisting renal calculi in children: role of metabolic abnormalities.	2001 Mar	11248635
Dehydroascorbic acid and oxidative stress in haemodialysis patients.	2001 Mar	11239034
Binding of urate and caffeine to haemocyanin analysed by isothermal titration calorimetry.	2001 Mar	11171426
Red wine polyphenols, in the absence of alcohol, reduce lipid peroxidative stress in smoking subjects.	2001 Mar 15	11295361
Flavonoids and urate antioxidant interplay in plasma oxidative stress.	2001 May	11506190
Functional reconstitution, membrane targeting, genomic structure, and chromosomal localization of a human urate transporter.	2001 May	11342574
Two types of urate binding sites on hemocyanin from the crayfish Astacus leptodactylus: an ITC study.	2001 May 18	11407645
Intracellular pH, intrauterine growth and the insulin resistance syndrome.	2001 Nov	11722471
Urate oxidase in the prophylaxis or treatment of hyperuricemia: the United States experience.	2001 Oct	11694947
Influence of plasma glutathione levels on radiation mucositis.	2001 Oct 1	11583019
Concentrations of nucleotides, nucleosides, purine bases, oxypurines, uric acid, and neuron-specific enolase in the cerebrospinal fluid of children with sepsis.	2001 Sep	11575617
Suicide inactivation of xanthine oxidoreductase during reduction of inorganic nitrite to nitric oxide.	2001 Sep 1	11513730
Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite.	2002 Jan	11788457
Electrosynthesis of poly-o-diaminobenzene on the Prussian Blue modified electrodes for improvement of hydrogen peroxide transducer characteristics.	2002 Jan	11786361
Superoxide mediates shock wave induction of ERK-dependent osteogenic transcription factor (CBFA1) and mesenchymal cell differentiation toward osteoprogenitors.	2002 Mar 29	11784711

Patents

Sample Use Guides

In Vivo Use Guide

Mice: twice daily with 10 mg per dose for 7 days

Route of Administration: Intraperitoneal

In Vitro Use Guide

Uric acid (5 mg/dL) significantly increased MCP-1 production by rat vascular smooth muscle cells at 3, 6, and 24 hours when compared with that of control media.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:44:08 GMT 2025` Edited by `admin` on `Mon Mar 31 23:44:08 GMT 2025`
Record UNII	1TX0E9ZJ0W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

URIC ACID, DISODIUM SALT

Preferred Name

English

DISODIUM URATE

Common Name

English

1H-PURINE-2,6,8(3H)-TRIONE, 7,9-DIHYDRO-, SODIUM SALT (1:2)

Systematic Name

English

Code System Code Type Description

CAS

134-69-0