XANTHINE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H4N4O2
Molecular Weight	152.1109
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C1NC2=C(NC=N2)C(=O)N1

InChI

InChIKey=LRFVTYWOQMYALW-UHFFFAOYSA-N

InChI=1S/C5H4N4O2/c10-4-2-3(7-1-6-2)8-5(11)9-4/h1H,(H3,6,7,8,9,10,11)

HIDE SMILES / InChI

Molecular Formula	C5H4N4O2
Molecular Weight	152.1109
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Pharmacotherapeutical reduction of post-hypoxic-ischemic brain injury in the newborn.	2001	11275665
Free radicals and brain damage in the newborn.	2001	11275648
Doxofylline: a new generation xanthine bronchodilator devoid of major cardiovascular adverse effects.	2001	11268710
Reactive oxygen species (ROS)-generating oxidases in the normal rabbit cornea and their involvement in the corneal damage evoked by UVB rays.	2001 Apr	11332708
Photoreactivation of alloxanthine-inhibited xanthine oxidase.	2001 Apr	11332041
Abnormal Ca2+ signalling in vascular endothelial cells from spontaneously hypertensive rats: role of free radicals.	2001 Apr	11330875
Serum xanthine oxidase in human liver disease.	2001 Apr	11316169
Effect of hypoxia, oxidative stress and lipopolysaccharides on the release of prostaglandins and cytokines from human term placental explants.	2001 Apr	11312628
Properties of tomato powders as additives for food fortification and stabilization.	2001 Apr	11308364
Analysis of peroxynitrite reactions with guanine, xanthine, and adenine nucleosides by high-pressure liquid chromatography with electrochemical detection: C8-nitration and -oxidation.	2001 Apr	11304133
Effect of reactive oxygen species on fetal lung maturation.	2001 Apr	11301161
Xanthine oxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis.	2001 Apr	11287035
Functional characterization of a maize purine transporter by expression in Aspergillus nidulans.	2001 Apr	11283348
The chemical work of Alexander and Jane Marcet.	2001 Apr	11274044
Generation of oxidative stress contributes to the development of pulmonary hypertension induced by hypoxia.	2001 Apr	11247927
Insight into the chemistry of flavin reduction and oxidation in Escherichia coli dihydroorotate dehydrogenase obtained by rapid reaction studies.	2001 Apr 10	11284694
Effects of tocopheryl quinone on the heart: model experiments with xanthine oxidase, heart mitochondria, and isolated perfused rat hearts.	2001 Apr 15	11295529
Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II.	2001 Apr 20	11302742
Phosphorylation of xanthine dehydrogenase/oxidase in hypoxia.	2001 Apr 27	11278616
Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors.	2001 Apr 9	11294382
Effects of L-arginine cardioplegia on myocardium.	2001 Feb	11315126
Prevention of deleterious effects of reperfusion injury using one-week high-dose allopurinol.	2001 Feb	11281195
Caffeine metabolism before and after liver transplantation.	2001 Feb	11270802
Evaluation of health aspects of kojic acid in food.	2001 Feb	11259181
Characterization of DNA damage at purine residues in oligonucleotides and calf thymus DNA induced by the mutagen 1-nitrosoindole-3-acetonitrile.	2001 Feb	11258964
Cerebral ischemia in humans after traumatic brain injury.	2001 Feb	11258358
Interstitial brain adenosine and xanthine increase during jugular venous oxygen desaturations in humans after traumatic brain injury.	2001 Feb	11246323
A simple technique for the simultaneous determination of molecular weight and activity of superoxide dismutase using SDS-PAGE.	2001 Feb 26	11245894
Xanthine oxidase activity and blood glutathione redox ratio in infants and children with septic shock syndrome.	2001 Jan	11280638
Effect of poly ICLC treatment on hepatic oxidative stress and antioxidant defense indices in Plasmodium yoelii nigeriensis infected mice.	2001 Jan-Feb	11286134
The effects of delta sleep-inducing peptide on the intensity of lipid peroxidation and xanthine oxidase activity in rat tissues during cold stress.	2001 Jan-Feb	11265821
Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrite reduction. Evaluation of its role in nitric oxide generation in anoxic tissues.	2001 Jul 6	11312267
Tautomeric energetics of xanthine oxidase substrates: xanthine, 2-oxo-6-methylpurine, and lumazine.	2001 Mar	11330474
The release of the substrate for xanthine oxidase in hypertensive patients was suppressed by angiotensin converting enzyme inhibitors and alpha1-blockers.	2001 Mar	11327632
Antagonism of free-radical-induced damage of adlay seed and its antiproliferative effect in human histolytic lymphoma U937 monocytic cells.	2001 Mar	11312897
Molecular cloning of a cDNA coding for feline liver xanthine dehydrogenase.	2001 Mar	11307944
Inhibition of xanthine and monoamine oxidases by stilbenoids from Veratrum taliense.	2001 Mar	11301865
Aryl hydrocarbon receptor (AhR)-mediated induction of xanthine oxidase/xanthine dehydrogenase activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin.	2001 Mar	11243847
Effects of reactive oxygen species on proliferation of Chinese hamster lung fibroblast (V79) cells.	2001 Mar 15	11295367
Electron spin resonance characterization of the NAD(P)H oxidase in vascular smooth muscle cells.	2001 Mar 15	11295358
Enhancement of antioxidant and anti-inflammatory activities of bioflavonoid rutin by complexation with transition metals.	2001 Mar 15	11266652
Astrocytes overexpressing Cu,Zn superoxide dismutase have increased resistance to oxidative injury.	2001 Mar 15	11246233
Cytochrome C is a potent catalyst of dichlorofluorescin oxidation: implications for the role of reactive oxygen species in apoptosis.	2001 Mar 23	11264011
Cytosolic xanthine oxidoreductase mediated bioactivation of ethanol to acetaldehyde and free radicals in rat breast tissue. Its potential role in alcohol-promoted mammary cancer.	2001 Mar 7	11246119
Asafoetida inhibits early events of carcinogenesis: a chemopreventive study.	2001 Mar 9	11292069
ESR studies on reaction of saccharide with the free radicals generated from the xanthine oxidase/hypoxanthine system containing iron.	2001 Mar 9	11248231
Uric acid in cachectic and noncachectic patients with chronic heart failure: relationship to leg vascular resistance.	2001 May	11320368
Xanthine oxidase inhibitory activity of selected Australian native plants.	2001 May	11297862
Miniaturized amperometric biosensor based on xanthine oxidase for monitoring hypoxanthine in cell culture media.	2001 May 1	11319822
Atrial natriuretic peptide inhibits tumor necrosis factor-alpha production by interferon-gamma-activated macrophages via suppression of p38 mitogen-activated protein kinase and nuclear factor-kappa B activation.	2001 May 5	11257311

Patents

Substance Class	Chemical Created by `admin` on `Wed Jul 05 22:41:40 UTC 2023` Edited by `admin` on `Wed Jul 05 22:41:40 UTC 2023`
Record UNII	1AVZ07U9S7
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

XANTHINE

Official Name

English

XANTHINE [INCI]

Common Name

English

9H-PURINE-2,6(1H,3H)-DIONE

Systematic Name

English

XANTHIC OXIDE

Common Name

English

3,9-DIHYDRO-1H-PURINE-2,6-DIONE

Systematic Name

English

1H,3H,9H-XANTHINE

Common Name

English

1H-PURINE-2,6-DIOL

Systematic Name

English

3,9-DIHYDROPURINE-2,6-DIONE

Systematic Name

English

NSC-14664

Code

English

Xanthine [WHO-DD]

Common Name

English

1H-PURINE-2,6-DIONE, 3,7-DIHYDRO-

Systematic Name

English

2,6-DIOXO-1,2,3,6-TETRAHYDROPURINE

Systematic Name

English

2,6-DIOXOPURINE

Systematic Name

English

XANTHINE [MI]

Common Name

English

1H,3H,7H-XANTHINE

Common Name

English

PURINE-2,6(1H,3H)-DIONE

Systematic Name

English

1H-PURINE-2,6-DIONE, 3,9-DIHYDRO-

Systematic Name

English

Classification Tree Code System Code

LOINC

41227-0

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

LOINC

75144-6

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

LOINC

38371-1

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

LOINC

75129-7

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

LOINC

3131-0

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

LOINC

3132-8

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

LOINC

41230-4

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

EPA PESTICIDE CODE

116900

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

LOINC

72897-2

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

LOINC

41228-8

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

LOINC

58036-5

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

Code System Code Type Description

MESH

D019820

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

PRIMARY

EVMPD

SUB15733MIG

Created by admin on Wed Jul 05 22:41:40 UTC 2023 , Edited by admin on Wed Jul 05 22:41:40 UTC 2023

PRIMARY

PUBCHEM

1188

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

PRIMARY

FDA UNII

1AVZ07U9S7

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

PRIMARY

RXCUI

1311085

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

PRIMARY

RxNorm

SMS_ID

100000076747

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

PRIMARY

WIKIPEDIA

XANTHINE

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

PRIMARY

DAILYMED

1AVZ07U9S7

Created by admin on Wed Jul 05 22:41:40 UTC 2023 , Edited by admin on Wed Jul 05 22:41:40 UTC 2023

PRIMARY

NSC

14664

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

PRIMARY

CHEBI

48517

Created by admin on Wed Jul 05 22:41:40 UTC 2023 , Edited by admin on Wed Jul 05 22:41:40 UTC 2023

PRIMARY

EPA CompTox

DTXSID4035120

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

PRIMARY

CAS

69-89-6

Created by admin on Wed Jul 05 22:41:40 UTC 2023 , Edited by admin on Wed Jul 05 22:41:40 UTC 2023

PRIMARY

ECHA (EC/EINECS)

200-718-6

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

PRIMARY

CHEBI

17712

Created by admin on Wed Jul 05 22:41:40 UTC 2023 , Edited by admin on Wed Jul 05 22:41:40 UTC 2023

PRIMARY

DRUG BANK

DB02134

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

PRIMARY

MERCK INDEX

M11527

Created by admin on Wed Jul 05 22:41:41 UTC 2023 , Edited by admin on Wed Jul 05 22:41:41 UTC 2023

PRIMARY

Merck Index

CHEBI

15318

Created by admin on Wed Jul 05 22:41:40 UTC 2023 , Edited by admin on Wed Jul 05 22:41:40 UTC 2023

PRIMARY

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