U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C11H15N5O5
Molecular Weight 297.2673
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NELARABINE

SMILES

COC1=NC(N)=NC2=C1N=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O

InChI

InChIKey=IXOXBSCIXZEQEQ-UHTZMRCNSA-N
InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/m1/s1

HIDE SMILES / InChI
Molecular Formula C11H15N5O5
Molecular Weight 297.2673
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Arranon is a nucleoside metabolic inhibitor indicated for the treatment of patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma. It is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity. Administration of nelarabine in combination with adenosine deaminase inhibitors, such 195 as pentostatin, is not recommended. The most common (≥20%) adverse reactions were: anemia, thrombocytopenia, neutropenia, nausea, diarrhea, vomiting, constipation, fatigue, pyrexia, cough, and dyspnea

CNS Activity

CNS Penetrant
2554
Curator's Comment: Nelarabine is widely distributed throughout the body and lower levels detected in the CNS

Originator

GlaxoSmithKline
193
Curator's Comment: Nelarabine was transfered from GlaxoSmithKline to Novartis http://www.pharmaceutical-journal.com/news-and-analysis/notice-board/transfer-of-products-from-glaxosmithkline-to-novartis/20068469.article

Approval Year

2005
131
Targets

Targets

Primary TargetPharmacologyConditionPotency
DNA
278
Target ID: CHEMBL2311221
Binding Agent
1064
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
ARRANON

Approved Use

ARRANON is indicated for the treatment of patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma whose disease has not responded to or has relapsed following treatment with at least two chemotherapy regimens. This use is based on the induction of complete responses. Randomized trials demonstrating increased survival or other clinical benefit have not been conducted. ARRANON is a nucleoside metabolic inhibitor indicated for the treatment of patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma whose disease has not responded to or has relapsed following treatment with at least two chemotherapy regimens. This use is based on the induction of complete responses. Randomized trials demonstrating increased survival or other clinical benefit have not been conducted. (1)

Launch Date

2005
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
52 μM
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/16953392
35 mg/kg single, intravenous
dose: 35 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
NELARABINE blood
Macaca mulatta
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
2820 μM × min
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/16953392
35 mg/kg single, intravenous
dose: 35 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
NELARABINE blood
Macaca mulatta
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
25 min
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/16953392
35 mg/kg single, intravenous
dose: 35 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
NELARABINE blood
Macaca mulatta
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
16.5 min
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/10694549
75 mg/kg 2 times / hour multiple, intravenous
dose: 75 mg/kg
route of administration: Intravenous
experiment type: MULTIPLE
co-administered:
NELARABINE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
2900 mg/m2 3 times / 3 weeks multiple, intravenous
Highest studied dose
Dose: 2900 mg/m2, 3 times / 3 weeks
Route: intravenous
Route: multiple
Dose: 2900 mg/m2, 3 times / 3 weeks
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf
unhealthy, adult
n = 2
Health Status: unhealthy
Age Group: adult
Population Size: 2
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf
1500 mg/m2 3 times / 3 weeks multiple, intravenous
Recommended
Dose: 1500 mg/m2, 3 times / 3 weeks
Route: intravenous
Route: multiple
Dose: 1500 mg/m2, 3 times / 3 weeks
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf
Other AEs: Somnolence, Convulsions...
Other AEs:
Somnolence (severe)
Convulsions (severe)
Numbness (severe)
Paresthesia (severe)
Weakness (severe)
Paralysis (severe)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf
1200 mg/m2 3 times / 3 weeks multiple, intravenous
Dose: 1200 mg/m2, 3 times / 3 weeks
Route: intravenous
Route: multiple
Dose: 1200 mg/m2, 3 times / 3 weeks
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
unhealthy, adult
n = 31
Health Status: unhealthy
Age Group: adult
Population Size: 31
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
DLT: Weakness, Ataxia...
Dose limiting toxicities:
Weakness (2 patients)
Ataxia (2 patients)
Confusion (2 patients)
Coma (2 patients)
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
1800 mg/m2 3 times / 3 weeks multiple, intravenous
Dose: 1800 mg/m2, 3 times / 3 weeks
Route: intravenous
Route: multiple
Dose: 1800 mg/m2, 3 times / 3 weeks
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
unhealthy, adult
n = 4
Health Status: unhealthy
Age Group: adult
Population Size: 4
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
DLT: Weakness, Ataxia...
Dose limiting toxicities:
Weakness (3 patients)
Ataxia (3 patients)
Confusion (3 patients)
Coma (3 patients)
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
2250 mg/m2 1 times / day multiple, intravenous
Highest studied dose
Dose: 2250 mg/m2, 1 times / day
Route: intravenous
Route: multiple
Dose: 2250 mg/m2, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
unhealthy, child
n = 1
Health Status: unhealthy
Age Group: child
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
Other AEs: Somnolence...
Other AEs:
Somnolence (severe, 1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
AEs

AEs

AESignificanceDosePopulation
Convulsions severe
1500 mg/m2 3 times / 3 weeks multiple, intravenous
Recommended
Dose: 1500 mg/m2, 3 times / 3 weeks
Route: intravenous
Route: multiple
Dose: 1500 mg/m2, 3 times / 3 weeks
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf
Numbness severe
1500 mg/m2 3 times / 3 weeks multiple, intravenous
Recommended
Dose: 1500 mg/m2, 3 times / 3 weeks
Route: intravenous
Route: multiple
Dose: 1500 mg/m2, 3 times / 3 weeks
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf
Paralysis severe
1500 mg/m2 3 times / 3 weeks multiple, intravenous
Recommended
Dose: 1500 mg/m2, 3 times / 3 weeks
Route: intravenous
Route: multiple
Dose: 1500 mg/m2, 3 times / 3 weeks
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf
Paresthesia severe
1500 mg/m2 3 times / 3 weeks multiple, intravenous
Recommended
Dose: 1500 mg/m2, 3 times / 3 weeks
Route: intravenous
Route: multiple
Dose: 1500 mg/m2, 3 times / 3 weeks
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf
Somnolence severe
1500 mg/m2 3 times / 3 weeks multiple, intravenous
Recommended
Dose: 1500 mg/m2, 3 times / 3 weeks
Route: intravenous
Route: multiple
Dose: 1500 mg/m2, 3 times / 3 weeks
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf
Weakness severe
1500 mg/m2 3 times / 3 weeks multiple, intravenous
Recommended
Dose: 1500 mg/m2, 3 times / 3 weeks
Route: intravenous
Route: multiple
Dose: 1500 mg/m2, 3 times / 3 weeks
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021877lbl.pdf
Ataxia 2 patients
DLT
1200 mg/m2 3 times / 3 weeks multiple, intravenous
Dose: 1200 mg/m2, 3 times / 3 weeks
Route: intravenous
Route: multiple
Dose: 1200 mg/m2, 3 times / 3 weeks
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
unhealthy, adult
n = 31
Health Status: unhealthy
Age Group: adult
Population Size: 31
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
Coma 2 patients
DLT
1200 mg/m2 3 times / 3 weeks multiple, intravenous
Dose: 1200 mg/m2, 3 times / 3 weeks
Route: intravenous
Route: multiple
Dose: 1200 mg/m2, 3 times / 3 weeks
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
unhealthy, adult
n = 31
Health Status: unhealthy
Age Group: adult
Population Size: 31
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
Confusion 2 patients
DLT
1200 mg/m2 3 times / 3 weeks multiple, intravenous
Dose: 1200 mg/m2, 3 times / 3 weeks
Route: intravenous
Route: multiple
Dose: 1200 mg/m2, 3 times / 3 weeks
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
unhealthy, adult
n = 31
Health Status: unhealthy
Age Group: adult
Population Size: 31
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
Weakness 2 patients
DLT
1200 mg/m2 3 times / 3 weeks multiple, intravenous
Dose: 1200 mg/m2, 3 times / 3 weeks
Route: intravenous
Route: multiple
Dose: 1200 mg/m2, 3 times / 3 weeks
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
unhealthy, adult
n = 31
Health Status: unhealthy
Age Group: adult
Population Size: 31
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
Ataxia 3 patients
DLT
1800 mg/m2 3 times / 3 weeks multiple, intravenous
Dose: 1800 mg/m2, 3 times / 3 weeks
Route: intravenous
Route: multiple
Dose: 1800 mg/m2, 3 times / 3 weeks
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
unhealthy, adult
n = 4
Health Status: unhealthy
Age Group: adult
Population Size: 4
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
Coma 3 patients
DLT
1800 mg/m2 3 times / 3 weeks multiple, intravenous
Dose: 1800 mg/m2, 3 times / 3 weeks
Route: intravenous
Route: multiple
Dose: 1800 mg/m2, 3 times / 3 weeks
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
unhealthy, adult
n = 4
Health Status: unhealthy
Age Group: adult
Population Size: 4
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
Confusion 3 patients
DLT
1800 mg/m2 3 times / 3 weeks multiple, intravenous
Dose: 1800 mg/m2, 3 times / 3 weeks
Route: intravenous
Route: multiple
Dose: 1800 mg/m2, 3 times / 3 weeks
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
unhealthy, adult
n = 4
Health Status: unhealthy
Age Group: adult
Population Size: 4
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
Weakness 3 patients
DLT
1800 mg/m2 3 times / 3 weeks multiple, intravenous
Dose: 1800 mg/m2, 3 times / 3 weeks
Route: intravenous
Route: multiple
Dose: 1800 mg/m2, 3 times / 3 weeks
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
unhealthy, adult
n = 4
Health Status: unhealthy
Age Group: adult
Population Size: 4
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
Somnolence severe, 1 patient
2250 mg/m2 1 times / day multiple, intravenous
Highest studied dose
Dose: 2250 mg/m2, 1 times / day
Route: intravenous
Route: multiple
Dose: 2250 mg/m2, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
unhealthy, child
n = 1
Health Status: unhealthy
Age Group: child
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/15908649
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
inhibitor
1767
inhibitor
1852

OverviewOther

Other InhibitorOther SubstrateOther Inducer
CYP1A2
1524

CYP2A6
707

CYP2B6
810

CYP2C8
911

CYP2C19
1478

P-gp
1461

CYP
111
CYP
270

P-gp
1537
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
CYP1A2
1692
 no [IC50 >100 uM]
CYP2A6
739
 no [IC50 >100 uM]
CYP2B6
1001
 no [IC50 >100 uM]
CYP2C19
1553
 no [IC50 >100 uM]
CYP2C8
965
 no [IC50 >100 uM]
CYP2C9
1819
 no [IC50 >100 uM]
CYP2D6
1891
 no [IC50 >100 uM]
CYP
147
 no
P-gp
1650
 no
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
CYP
270
 no
P-gp
1537
 no
Sourcing

Sourcing

Vendor/AggregatorIDURL
ChEBI
CHEBI:63612
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:63612
ChemicalBook
CB01011878
https://www.chemicalbook.com/ChemicalProductProperty_EN_CB01011878
MolPort
MolPort-006-167-760
https://www.molport.com/shop/molecule-link/MolPort-006-167-760
Selleck Chemicals
Arranon
http://www.selleckchem.com/products/Arranon.html
ZINC
ZINC000003823492
http://zinc15.docking.org/substances/ZINC000003823492
eMolecules
32176516
https://www.emolecules.com/cgi-bin/more?vid=32176516
PubMed

PubMed

TitleDatePubMed
6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virus.
1991 May
Evaluation of the combination of nelarabine and fludarabine in leukemias: clinical response, pharmacokinetics, and pharmacodynamics in leukemia cells.
2001 Apr 15
Nucleoside analogues in the treatment of haematological malignancies.
2001 Jun
Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase.
2002 Jun 1
New nucleoside analogs in the treatment of hematological disorders.
2004 May-Jun
Nelarabine: a nucleoside analog with efficacy in T-cell and other leukemias.
2005 Jun
Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies.
2005 May 20
Efficacy of low dose clofarabine in refractory precursor T- acute lymphoblastic leukemia.
2006 Dec
Clofarabine and nelarabine: two new purine nucleoside analogs.
2006 Nov
Nelarabine: a new purine analog in the treatment of hematologic malignancies.
2006 Sep
Nelarabine in the treatment of refractory T-cell malignant diseases.
2006 Sep
Approval summary: nelarabine for the treatment of T-cell lymphoblastic leukemia/lymphoma.
2006 Sep 15
Role of nelarabine in the treatment of T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma.
2007 Dec
Clinical management of T-cell malignancies: current perspectives, key issues, and emerging therapies.
2007 Dec
New drugs 07, part I.
2007 Feb
The long and winding road of the clinical development of Nelarabine.
2007 Jan
Plasma and cerebrospinal fluid pharmacokinetics of nelarabine in nonhuman primates.
2007 May
Cytotoxic nucleoside analogues: different strategies to improve their clinical efficacy.
2008
Nelarabine.
2008
Treating refractory leukemias in childhood, role of clofarabine.
2008 Apr
Beyond the guidelines in the treatment of peripheral T-cell lymphoma: new drug development.
2008 Apr
Gateways to clinical trials.
2008 Jan-Feb
FDA drug approval summary: nelarabine (Arranon) for the treatment of T-cell lymphoblastic leukemia/lymphoma.
2008 Jun
Novel purine nucleoside analogues for hematological malignancies.
2008 Jun
Phase I trial of nelarabine in indolent leukemias.
2008 Mar 1
Gateways to clinical trials.
2008 May
T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993).
2009 Dec 10
Nelarabine: new drug. T-lymphoblastic leukaemia/lymphoma: more evaluation needed.
2009 Feb
[Severe liver injury following nelarabine chemotherapy for T-cell lymphoblastic lymphoma].
2009 Jan
Novel therapies for relapsed acute lymphoblastic leukemia.
2009 Jul
Nelarabine induced complete remission in an adult with refractory T-lineage acute lymphoblastic leukemia: A case report and review of the literature.
2009 Jul
Glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia is associated with a proliferative metabolism.
2009 Jun 16
Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases.
2009 Mar 23
Hydronephrosis Resulting from Bilateral Ureteral Stenosis: A Late Complication of Polyoma BK Virus Cystitis?
2010
Use of clofarabine for acute childhood leukemia.
2010 Jun 24
Rare tumors research in emerging countries.
2010 Sep 30
Patents

Patents

05424295
2
05492897
1
05539098
2
05747472
1
05821236
1
20010044451
26
JP2010526091A
24
JP2011505386A
3
JP2011527579A
29

Sample Use Guides

In Vivo Use Guide
Adult: 1,500 mg/m² over 2 hours on Days 1, 3, and 5 repeated every 21 days Pediatric: 650 mg/m² over 1 hour daily for 5 consecutive days repeated every 21 days
Route of Administration: Intravenous
In Vitro Use Guide
The in vitro efficacy of nelarabine was assessed in a panel of acute lymphoblastic leukaemia (ALL) cell lines. IC50 values were 0.067-2.15 uM.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:56:14 GMT 2023
Edited
by admin
on Fri Dec 15 15:56:14 GMT 2023
Record UNII
60158CV180
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NELARABINE
EMA EPAR   INN   JAN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
506U78
Code English
ARRANON
Brand Name English
NELARABINE [ORANGE BOOK]
Common Name English
NELARABINE [EMA EPAR]
Common Name English
506U
Code English
ATTRIANCE
Brand Name English
nelarabine [INN]
Common Name English
NELZARABINE
Common Name English
NELARABINE [MART.]
Common Name English
MAY
Code English
9H-PURIN-2-AMINE, 9-.BETA.-D-ARABINOFURANOSYL-6-METHOXY-
Systematic Name English
NELARABINE [MI]
Common Name English
NELARABINE [VANDF]
Common Name English
9-.BETA.-D-ARABINOFURANOSYL-6-METHOXY-9H-PURIN-2-AMINE
Common Name English
NSC-755985
Code English
Nelarabine [WHO-DD]
Common Name English
NSC-686673
Code English
NSC-759876
Code English
NELARABINE [JAN]
Common Name English
NELARABINE [USAN]
Common Name English
GW-506U78
Code English
2-AMINO-9-.BETA.-D-ARABINOFURANOSYL-6-METHOXY-9H-PURINE
Systematic Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 125999
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
WHO-ATC L01BB07
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
EU-Orphan Drug EU/3/05/293
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
NDF-RT N0000175595
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
NCI_THESAURUS C1556
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
EMA ASSESSMENT REPORTS ATTRIANCE (AUTHORIZED: PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA)
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
LIVERTOX NBK548515
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
WHO-VATC QL01BB07
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
NDF-RT N0000000233
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
FDA ORPHAN DRUG 184404
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
Code System Code Type Description
MESH
C104457
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
PRIMARY
SMS_ID
100000085469
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
PRIMARY
WIKIPEDIA
NELARABINE
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
PRIMARY
PUBCHEM
3011155
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
PRIMARY
DRUG BANK
DB01280
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
PRIMARY
DAILYMED
60158CV180
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
PRIMARY
MERCK INDEX
m7797
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
PRIMARY Merck Index
INN
7704
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
PRIMARY
FDA UNII
60158CV180
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
PRIMARY
CHEBI
63612
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
PRIMARY
EVMPD
SUB09188MIG
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
PRIMARY
RXCUI
274771
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID6046842
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
PRIMARY
IUPHAR
7090
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
PRIMARY
NSC
686673
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
PRIMARY
CAS
121032-29-9
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
PRIMARY
NSC
755985
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
PRIMARY
ChEMBL
CHEMBL1201112
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
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DRUG CENTRAL
1892
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
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NCI_THESAURUS
C1704
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
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NSC
759876
Created by admin on Fri Dec 15 15:56:14 GMT 2023 , Edited by admin on Fri Dec 15 15:56:14 GMT 2023
PRIMARY
Related Record Type Details
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
Plasma protein binding is independent on nelarabine concentrations.
BINDING
Structure of NELARABINE
EXCRETED UNCHANGED
URINE
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METABOLITE -> PARENT
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Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC SINGLE DOSE ADMINISTRATION

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