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Restrict the search for
nitroglycerin
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There is one exact (name or code) match for nitroglycerin
Status:
US Approved Rx
(2018)
Source:
ANDA207141
(2018)
Source URL:
First marketed in 1921
Source:
Spirit of Glyceryl Trinitrate U.S.P.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Pentaerythritol tetranitrate is an organic nitrate that has been used for the treatment of angina pectoris. Upon administration, the drug undergoes exstensive metabolism to NO which causes vasodilation and the relaxation of smooth muscle cells. The compound belongs to a familiy of explosive substances and may be used accordingly.
Status:
US Approved Rx
(2018)
Source:
ANDA207141
(2018)
Source URL:
First marketed in 1921
Source:
Spirit of Glyceryl Trinitrate U.S.P.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Pentaerythritol tetranitrate is an organic nitrate that has been used for the treatment of angina pectoris. Upon administration, the drug undergoes exstensive metabolism to NO which causes vasodilation and the relaxation of smooth muscle cells. The compound belongs to a familiy of explosive substances and may be used accordingly.
Status:
US Approved Rx
(2024)
Source:
ANDA217617
(2024)
Source URL:
First approved in 1992
Source:
ZEBETA by TEVA WOMENS
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Bisoprolol is a cardioselective beta1-adrenergic blocking agent. It lower the heart rate and blood pressure and may be used to reduce workload on the heart and hence oxygen demands. This results in a reduction of heart rate, cardiac output, systolic and diastolic blood pressure, and possibly reflex orthostatic hypotension. Bisoprolol can be used to treat cardiovascular diseases such as hypertension, coronary heart disease, arrhythmias, ischemic heart diseases, and myocardial infarction after the acute event. General side effects are: fatigue, asthenia, chest pain, malaise, edema, weight gain, angioedema. Concurrent use of rifampin increases the metabolic clearance of bisoprolol fumarate, shortening its elimination half-life.
Status:
US Approved Rx
(2018)
Source:
ANDA207141
(2018)
Source URL:
First marketed in 1921
Source:
Spirit of Glyceryl Trinitrate U.S.P.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Pentaerythritol tetranitrate is an organic nitrate that has been used for the treatment of angina pectoris. Upon administration, the drug undergoes exstensive metabolism to NO which causes vasodilation and the relaxation of smooth muscle cells. The compound belongs to a familiy of explosive substances and may be used accordingly.
Glyceryl 2-nitrate (G-2-N) is the major metabolite of glyceryl trinitrate. Strips of rat aorta contracted with potassium chloride or with norepinephrine were relaxed by G-2-N. After oral administration to the anaesthetized rat or to the conscious dog G-2-N exhibited antianginal and hypotensive activity. The hypotensive and also cardiovascular activity of G-2-N lasted much longer than that of glyceryl trinitrate.
Glyceryl 1-nitrate (G-1-N) is an intermediate metabolic product in the stepwise de-esterification of glyceryl trinitrate (GTN) in animals and humans. It belongs to the group of orally effective longacting antianginal nitrates. In anesthetized rabbits, intravenous (L) G-1-N reduced the blood pressure slightly more than (D) G-1-N, while in the conscious dog the blood pressure lowering effect of (D) G-1-N was greater and had a much longer duration (4-6 versus 2 h) than that of (L)G-1-N. The differences in dogs are probably explained by enantiospecific pharmacokinetics: (D) G-1-N had higher plasma levels and showed a longer half-life of elimination than (L) G-1-N. From the pharmacokinetic point of view, the drug offers clear advantage over glyceryl trinitrate in clinical use: G-1-N is orally available - owing to its relatively low clearance it stays much longer in the body than GTN - kinetic parameters are predictable with low coefficients of variation - and the denitration products of G-1-N are expected to be pharmacologically neutral.
Status:
US Previously Marketed
First approved in 1940
Class (Stereo):
CHEMICAL (ABSOLUTE)
Mannitol hexanitrate, a sugar alcohol that possesses explosive properties. There are existed mention that this compound had been used for the treatment of hypertension and was effective against an angina attack.
Status:
US Previously Marketed
Source:
Amyl Nitrite U.S.P.
(1880)
Source URL:
First marketed in 1880
Source:
Amyl Nitrite U.S.P.
Source URL:
Class:
MIXTURE
