MANNITOL HEXANITRATE

US Previously Marketed

First approved in 1940

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C6H8N6O18
Molecular Weight	452.1571
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[O-][N+](=O)OC[C@@H](O[N+]([O-])=O)[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O[N+]([O-])=O

InChI

InChIKey=DGMJZELBSFOPHH-KVTDHHQDSA-N

InChI=1S/C6H8N6O18/c13-7(14)25-1-3(27-9(17)18)5(29-11(21)22)6(30-12(23)24)4(28-10(19)20)2-26-8(15)16/h3-6H,1-2H2/t3-,4-,5-,6-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C6H8N6O18
Molecular Weight	452.1571
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://doi.org/10.3181/00379727-48-13224P

Mannitol hexanitrate, a sugar alcohol that possesses explosive properties. There are existed mention that this compound had been used for the treatment of hypertension and was effective against an angina attack.

Approval Year

Doses

Dose	Population	Adverse events
60 mg 4 times / day multiple, oral Recommended Dose: 60 mg, 4 times / day Route: oral Route: multiple Dose: 60 mg, 4 times / day Co-administed with:: Rauwolfia micrantha (powdered whole root)(60 mg; 4/day) Rutin(60 mg; 4/day) Sources: https://pubmed.ncbi.nlm.nih.gov/13282524/	unhealthy, adult n = 11 Health Status: unhealthy Condition: hypertension Age Group: adult Sex: M+F Population Size: 11 Sources: https://pubmed.ncbi.nlm.nih.gov/13282524/	Sources: https://pubmed.ncbi.nlm.nih.gov/13282524/
360 mg 4 times / day multiple, oral Recommended Dose: 360 mg, 4 times / day Route: oral Route: multiple Dose: 360 mg, 4 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13250697/	unhealthy n = 15 Health Status: unhealthy Condition: hypertension Population Size: 15 Sources: https://pubmed.ncbi.nlm.nih.gov/13250697/	Other AEs: Anorexia, Ventricular ectopic beats... Other AEs: Anorexia (mild, 1 patient) Ventricular ectopic beats (3 patients) Rashes, eruptions and exanthems NEC (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/13250697/

AEs

AE	Significance	Dose	Population
Rashes, eruptions and exanthems NEC	1 patient	360 mg 4 times / day multiple, oral Recommended Dose: 360 mg, 4 times / day Route: oral Route: multiple Dose: 360 mg, 4 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13250697/	unhealthy n = 15 Health Status: unhealthy Condition: hypertension Population Size: 15 Sources: https://pubmed.ncbi.nlm.nih.gov/13250697/
Ventricular ectopic beats	3 patients	360 mg 4 times / day multiple, oral Recommended Dose: 360 mg, 4 times / day Route: oral Route: multiple Dose: 360 mg, 4 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13250697/	unhealthy n = 15 Health Status: unhealthy Condition: hypertension Population Size: 15 Sources: https://pubmed.ncbi.nlm.nih.gov/13250697/
Anorexia	mild, 1 patient	360 mg 4 times / day multiple, oral Recommended Dose: 360 mg, 4 times / day Route: oral Route: multiple Dose: 360 mg, 4 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13250697/	unhealthy n = 15 Health Status: unhealthy Condition: hypertension Population Size: 15 Sources: https://pubmed.ncbi.nlm.nih.gov/13250697/

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1L1VYV
Alfa Chemistry	15825-70-4
Alfa Chemistry	ACM15825704
Chemieliva Pharmaceutical Co., Ltd	PBCM1201958
HongKong Chemhere	15825-70-4
MuseChem	M067568	https://www.musechem.com/product/M067568.html
MuseChem	M078872	https://www.musechem.com/product/M078872.html
SelectLab Chemicals GmbH	Ex171
THE BioTek	bt-431861	https://www.thebiotek.com/product/others/bt-431861
ZINC	ZINC000008214602	http://zinc15.docking.org/substances/ZINC000008214602

PubMed

Title	Date	PubMed
Effects of glycerol trinitrate, mannitol hexanitrate and erythritol tetranitrate on electron transport and phosphorylation in liver mitochondria.	1971 Mar	5004772
Simultaneous semiautomated determination of pentaerythritol tetranitrate or mannitol hexanitrate and phenobarbital in tablets.	1973 Oct	4752121

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:56:33 UTC 2023` Edited by `admin` on `Sat Dec 16 16:56:33 UTC 2023`
Record UNII	99AU28W1G9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MANNITOL HEXANITRATE

Official Name

English

mannitol hexanitrate [INN]

Common Name

English

MANNITOL HEXANITRATE [HSDB]

Common Name

English

D-MANNITOL HEXANITRATE [MI]

Common Name

English

NA0133

Code

English

NITROMANNITE

Common Name

English

HEXANITRATE OF D-MANNITOL

Common Name

English

MANNITOL HEXANITRATE [VANDF]

Common Name

English

Mannitol hexanitrate [WHO-DD]

Common Name

English

MANNITOL HEXANITRATE [MART.]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 250.102