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Details

Stereochemistry ACHIRAL
Molecular Formula NO
Molecular Weight 30.0061
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NITRIC OXIDE

SMILES

[N]=O

InChI

InChIKey=ODUCDPQEXGNKDN-UHFFFAOYSA-N
InChI=1S/HNO/c1-2/h1H

HIDE SMILES / InChI

Molecular Formula NO
Molecular Weight 30.0061
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

In mammals Nitric Oxide (NO) is an important cellular signaling molecule involved in many physiological and pathological processes. It is a powerful vasodilator with a short half-life of a few seconds in the blood. Low levels of nitric oxide production are important in protecting organs such as the liver from ischemic damage. Nitric oxide production is associated with nonalcoholic fatty liver disease (NAFLD) and is essential for hepatic lipid metabolism under starvation. Nitric oxide (INOmax) is indicated to improve oxygenation and reduce the need for extracorporeal membrane oxygenation in term and near-term (>34 weeks gestation) neonates with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension in conjunction with ventilatory support and other appropriate agents. Nitric oxide relaxes vascular smooth muscle by binding to the heme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic guanosine 3',5'-monophosphate, which then leads to vasodilation. When inhaled, nitric oxide selectively dilates the pulmonary vasculature, and because of efficient scavenging by hemoglobin, has minimal effect on the systemic vasculature. INOmax appears to increase the partial pressure of arterial oxygen (PaO2) by dilating pulmonary vessels in better-ventilated areas of the lung, redistributing pulmonary blood flow away from lung regions with low ventilation/perfusion (V/Q) ratios toward regions with normal ratios. NO, can be generated in large quantities and has detrimental effects on the CNS. NO has been shown to increase permeability of the BBB, allowing substances to enter into the brain passively. Because of its importance in neuroscience, physiology, and immunology, NO was proclaimed "Molecule of the Year" in 1992. Research into its function led to the 1998 Nobel Prize for discovering the role of nitric oxide as a cardiovascular signaling molecule (Furchgott, Murad and Ignarro).

CNS Activity

Originator

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions
PubMed

PubMed

TitleDatePubMed
[The effect of nitric oxide administration on pateints with pulmonary hypertension: a dose-response study].
1998 Feb
N-Acetyl-cysteine inhibition of encephalomyelitis Theiler's virus-induced nitric oxide and tumour necrosis factor-alpha production by murine astrocyte cultures.
1999
Effects of amlodipine on nitric oxide synthase mRNA expression and coronary microcirculation in prolonged nitric oxide blockade-induced hypertensive rats.
1999 Aug
Increased vulnerability of neuronal cell lines to sodium nitroprusside-mediated toxicity is caused by the decreased level of nitric oxide metabolites.
1999 Aug-Oct
The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitro.
1999 Jul
Arterial function in nitric oxide-deficient hypertension: influence of long-term angiotensin II receptor antagonism.
1999 Jun
Modifications induced by LDL from type 1 diabetic patients on endothelial cells obtained from human umbilical vein.
1999 Nov
Beta2-adrenergic receptor stimulation inhibits nitric oxide generation by Mycobacterium avium infected macrophages.
1999 Nov 1
Nitric oxide induces Zn2+ release from metallothionein by destroying zinc-sulphur clusters without concomitant formation of S-nitrosothiol.
1999 Nov 15
Nitric oxide inhalation inhibits pulmonary apoptosis but not inflammatory injury in porcine meconium aspiration.
1999 Oct
Glyceryl trinitrate induces attacks of migraine without aura in sufferers of migraine with aura.
1999 Sep
Nitric oxide stimulates ACTH secretion and the transcription of the genes encoding for NGFI-B, corticotropin-releasing factor, corticotropin-releasing factor receptor type 1, and vasopressin in the hypothalamus of the intact rat.
1999 Sep 1
L-arginine partially reverses established adrenocorticotrophin-induced hypertension and nitric oxide deficiency in the rat.
2000
The potential role of nitric oxide in the hypertrophic growth of the left ventricle.
2000
Angiotensin in the nucleus tractus solitarii contributes to neurogenic hypertension caused by chronic nitric oxide synthase inhibition.
2000 Aug
Nitric oxide induces thymocyte apoptosis via a caspase-1-dependent mechanism.
2000 Aug 1
Residual pulmonary hypertension in children after treatment with inhaled nitric oxide: a follow-up study regarding cardiopulmonary and neurological symptoms.
2000 Dec
Inhibition of endogenous nitric oxide synthase potentiates ischemia-reperfusion-induced myocardial apoptosis via a caspase-3 dependent pathway.
2000 Feb
Vasopressin does not effect hypertension caused by long-term nitric oxide inhibition.
2000 Feb
Copper-dependent formation of disulfide-linked dimer of S100B protein.
2000 Feb 15
[Anorectics and pulmonary hypertension].
2000 Feb 16
Dexamethasone blocks sepsis-induced protection of the heart from ischemia reperfusion injury.
2000 Jan
Nitric oxide synthase in toxic epidermal necrolysis and Stevens-Johnson syndrome.
2000 Jan
Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8.
2000 Jan
Nitric oxide-producing CD11b(+)Ly-6G(Gr-1)(+)CD31(ER-MP12)(+) cells in the spleen of cyclophosphamide-treated mice: implications for T-cell responses in immunosuppressed mice.
2000 Jan 1
Glyceryl trinitrate induced headache in migraineurs - relation to attack frequency.
2000 Jul
Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).
2000 Jul
Metallothionein-III prevents glutamate and nitric oxide neurotoxicity in primary cultures of cerebellar neurons.
2000 Jul
Nitric oxide induces apoptosis in megakaryocytic cell lines.
2000 Jun 1
Acetaminophen inhibits iNOS gene expression in RAW 264.7 macrophages: differential regulation of NF-kappaB by acetaminophen and salicylates.
2000 Jun 16
Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide.
2000 May 9
The neurogenic vasodilator response to endothelin-1: a study in human skin in vivo.
2000 Nov
High-calcium diet enhances vasorelaxation in nitric oxide-deficient hypertension.
2000 Sep
Nitric oxide-induced headache in patients with chronic tension-type headache.
2000 Sep
Regulation of diaphragmatic nitric oxide synthase expression during hypobaric hypoxia.
2000 Sep
Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expressions by rutin, quercetin, and quercetin pentaacetate in RAW 264.7 macrophages.
2001
Beneficial effect of 1,25 dihydroxyvitamin D3 on cytokine-treated human pancreatic islets.
2001 Apr
Stimulation of cyclooxygenase-2-activity by nitric oxide-derived species in rat chondrocyte: lack of contribution to loss of cartilage anabolism.
2001 Apr 15
Lipopolysaccharide and interferon-gamma-induced nitric oxide production and protein oxidation in mouse peritoneal macrophages are affected by glutathione peroxidase-1 gene knockout.
2001 Aug 15
Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy.
2001 Aug 17
Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes.
2001 Feb
15-Deoxy-delta12,14-PGJ2, but not troglitazone, modulates IL-1beta effects in human chondrocytes by inhibiting NF-kappaB and AP-1 activation pathways.
2001 Jul 13
Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced release of nitric oxide.
2001 Jul 31
Prostaglandins and nitric oxide mediate superoxide-induced myocardial contractile dysfunction in isolated rat hearts.
2001 Jun
Nitric oxide inhalation increases alveolar gas exchange by decreasing deadspace volume.
2001 Jun
Neonatal pulmonary hypertension--urea-cycle intermediates, nitric oxide production, and carbamoyl-phosphate synthetase function.
2001 Jun 14
Calcitonin gene-related peptide levels during nitric oxide-induced headache in patients with chronic tension-type headache.
2001 Mar
Expression of inducible nitric oxide synthase in primary culture of rat bladder smooth muscle cells by plasma from cyclophosphamide-treated rats.
2001 Mar 23
Sildenafil (viagra) facilitates weaning of inhaled nitric oxide following placement of a biventricular-assist device.
2001 May
Nitric oxide and chronic HCV and HIV infections.
2001 May
Patents

Patents

Sample Use Guides

In Vivo Use Guide
20 ppm, maintained for up to 14 days or until the underlying oxygen desaturation has resolved
Route of Administration: Respiratory
Substance Class Chemical
Created
by admin
on Mon Oct 21 20:43:58 UTC 2019
Edited
by admin
on Mon Oct 21 20:43:58 UTC 2019
Record UNII
31C4KY9ESH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NITRIC OXIDE
EMA EPAR   EP   HSDB   JAN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
USAN  
Official Name English
NITRIC OXIDE [WHO-DD]
Common Name English
NITROGEN(II) OXIDE
Systematic Name English
NITROGEN OXIDE
Systematic Name English
NITRIC OXIDE [MART.]
Common Name English
NITROSYL RADICAL
Common Name English
NITRIC OXIDE [HSDB]
Common Name English
NITRIC OXIDE [EP]
Common Name English
NITRIC OXIDE [EMA EPAR]
Common Name English
OHM-11771
Code English
INOVENT
Common Name English
AMIDOGEN, OXO-
Common Name English
NITRIC OXIDE [JAN]
Common Name English
NITRIC OXIDE [MI]
Common Name English
NITRIC OXIDE [ORANGE BOOK]
Common Name English
NITRIC OXIDE [VANDF]
Common Name English
NITRIC OXIDE TRIMER
Common Name English
NITRIC OXIDE [USAN]
Common Name English
INOMAX
Brand Name English
NITROGEN MONOXIDE
Systematic Name English
NITROGEN OXIDE (NO)
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 603917
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
EU-Orphan Drug EU/3/15/1484
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
FDA ORPHAN DRUG 340811
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
FDA ORPHAN DRUG 368512
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
FDA ORPHAN DRUG 265708
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
FDA ORPHAN DRUG 551716
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
NDF-RT N0000175940
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
FDA ORPHAN DRUG 192104
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
FDA ORPHAN DRUG 638918
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
WHO-VATC QR07AX01
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
FDA ORPHAN DRUG 74493
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
FDA ORPHAN DRUG 443914
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
FDA ORPHAN DRUG 551616
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
CFR 21 CFR 862.3080
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
NCI_THESAURUS C687
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
FDA ORPHAN DRUG 90595
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
FDA ORPHAN DRUG 193304
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
EMA ASSESSMENT REPORTS INOMAX (AUTHORIZED: RESPITORY INSUFFICIENCY, HYPERTENSION, PULMONARY)
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
FDA ORPHAN DRUG 403613
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
NDF-RT N0000009909
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
WHO-ATC R07AX01
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
Code System Code Type Description
EVMPD
SUB12540MIG
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
PRIMARY
MERCK INDEX
M7934
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
PRIMARY Merck Index
RXCUI
7442
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
PRIMARY RxNorm
HSDB
10102-43-9
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
PRIMARY
DRUG BANK
DB00435
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
PRIMARY
NCI_THESAURUS
C695
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
PRIMARY
CAS
10102-43-9
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
PRIMARY
ChEMBL
CHEMBL1200689
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
PRIMARY
EPA CompTox
10102-43-9
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
PRIMARY
IUPHAR
2509
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
PRIMARY
ECHA (EC/EINECS)
233-271-0
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
PRIMARY
WIKIPEDIA
NITRIC OXIDE
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
PRIMARY
PUBCHEM
145068
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
PRIMARY
EVMPD
SUB03447MIG
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
PRIMARY
MESH
D009569
Created by admin on Mon Oct 21 20:43:58 UTC 2019 , Edited by admin on Mon Oct 21 20:43:58 UTC 2019
PRIMARY
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