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Details

Stereochemistry ACHIRAL
Molecular Formula NO
Molecular Weight 30.0061
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NITRIC OXIDE

SMILES

N=O

InChI

InChIKey=ODUCDPQEXGNKDN-UHFFFAOYSA-N
InChI=1S/HNO/c1-2/h1H

HIDE SMILES / InChI

Description
Curator's Comment:: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/24560804 http://www.reading.ac.uk/nitricoxide/intro/no/discovery.htm

In mammals Nitric Oxide (NO) is an important cellular signaling molecule involved in many physiological and pathological processes. It is a powerful vasodilator with a short half-life of a few seconds in the blood. Low levels of nitric oxide production are important in protecting organs such as the liver from ischemic damage. Nitric oxide production is associated with nonalcoholic fatty liver disease (NAFLD) and is essential for hepatic lipid metabolism under starvation. Nitric oxide (INOmax) is indicated to improve oxygenation and reduce the need for extracorporeal membrane oxygenation in term and near-term (>34 weeks gestation) neonates with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension in conjunction with ventilatory support and other appropriate agents. Nitric oxide relaxes vascular smooth muscle by binding to the heme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic guanosine 3',5'-monophosphate, which then leads to vasodilation. When inhaled, nitric oxide selectively dilates the pulmonary vasculature, and because of efficient scavenging by hemoglobin, has minimal effect on the systemic vasculature. INOmax appears to increase the partial pressure of arterial oxygen (PaO2) by dilating pulmonary vessels in better-ventilated areas of the lung, redistributing pulmonary blood flow away from lung regions with low ventilation/perfusion (V/Q) ratios toward regions with normal ratios. NO, can be generated in large quantities and has detrimental effects on the CNS. NO has been shown to increase permeability of the BBB, allowing substances to enter into the brain passively. Because of its importance in neuroscience, physiology, and immunology, NO was proclaimed "Molecule of the Year" in 1992. Research into its function led to the 1998 Nobel Prize for discovering the role of nitric oxide as a cardiovascular signaling molecule (Furchgott, Murad and Ignarro).

CNS Activity

Curator's Comment:: NO can be generated in large quantities and has detrimental effects on the CNS. NO has been shown to increase permeability of the BBB, allowing substances to enter into the brain passively.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
INOMAX

Approved Use

INOmax is a vasodilator indicated to improve oxygenation and reduce the need for extracorporeal membrane oxygenation in term and near-term (>34 weeks gestation) neonates with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension in conjunction with ventilatory support and other appropriate agents.

Launch Date

9.4582079E11
PubMed

PubMed

TitleDatePubMed
[The effect of nitric oxide administration on pateints with pulmonary hypertension: a dose-response study].
1998 Feb
L-arginine partially reverses established adrenocorticotrophin-induced hypertension and nitric oxide deficiency in the rat.
2000
Sodium nitroprusside-induced seizure and taurine release from rat hippocampus.
2000
Vascular effects of endothelin-1 in essential hypertension: relationship with cyclooxygenase-derived endothelium-dependent contracting factors and nitric oxide.
2000
The potential role of nitric oxide in the hypertrophic growth of the left ventricle.
2000
Nitric oxide-compromised hypertension: facts and enigmas.
2000
Protective role of intracellular glutathione against nitric oxide-induced necrosis in rat gastric mucosal cells.
2000 Apr
Angiotensin in the nucleus tractus solitarii contributes to neurogenic hypertension caused by chronic nitric oxide synthase inhibition.
2000 Aug
Nitric oxide induces thymocyte apoptosis via a caspase-1-dependent mechanism.
2000 Aug 1
Nitric oxide metabolites, prostaglandins and trigeminal vasoactive peptides in internal jugular vein blood during spontaneous migraine attacks.
2000 Dec
Residual pulmonary hypertension in children after treatment with inhaled nitric oxide: a follow-up study regarding cardiopulmonary and neurological symptoms.
2000 Dec
[Anorectics and pulmonary hypertension].
2000 Feb 16
Glyceryl trinitrate induced headache in migraineurs - relation to attack frequency.
2000 Jul
Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).
2000 Jul
Metallothionein-III prevents glutamate and nitric oxide neurotoxicity in primary cultures of cerebellar neurons.
2000 Jul
Nitric oxide induces apoptosis in megakaryocytic cell lines.
2000 Jun 1
Acetaminophen inhibits iNOS gene expression in RAW 264.7 macrophages: differential regulation of NF-kappaB by acetaminophen and salicylates.
2000 Jun 16
Recovery from withdrawal of inhaled nitric oxide and kinetics of nitric oxide-induced inhibition of nitric oxide synthase activity in vitro.
2000 Mar
Protective effect of bilobalide against nitric oxide-induced neurotoxicity in PC12 cells.
2000 May
Nitric oxide inhibits apoptosis via AP-1-dependent CD95L transactivation.
2000 May 1
The neurogenic vasodilator response to endothelin-1: a study in human skin in vivo.
2000 Nov
Inhibition of nitric oxide synthase enhances the myocardial toxicity of phenylpropanolamine.
2000 Nov
Role of nitric oxide in adrenocorticotrophin-induced hypertension: L-arginine effects reversed by N-nitro-L-arginine.
2000 Nov
Female sex steroids: effects upon microglial cell activation.
2000 Nov 1
Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway.
2000 Nov 15
Inhibition of inducible nitric oxide synthase gene expression by indomethacin or ibuprofen in beta-amyloid protein-stimulated J774 cells.
2000 Nov 17
Endothelins and endothelin receptor antagonists: therapeutic considerations for a novel class of cardiovascular drugs.
2000 Nov 7
High-calcium diet enhances vasorelaxation in nitric oxide-deficient hypertension.
2000 Sep
Nitric oxide-induced headache in patients with chronic tension-type headache.
2000 Sep
Regulation of diaphragmatic nitric oxide synthase expression during hypobaric hypoxia.
2000 Sep
Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expressions by rutin, quercetin, and quercetin pentaacetate in RAW 264.7 macrophages.
2001
Beneficial effect of 1,25 dihydroxyvitamin D3 on cytokine-treated human pancreatic islets.
2001 Apr
Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 is involved in gp130 resistance in cardiovascular system in rat treated with cardiotrophin-1 in vivo.
2001 Apr 13
Stimulation of cyclooxygenase-2-activity by nitric oxide-derived species in rat chondrocyte: lack of contribution to loss of cartilage anabolism.
2001 Apr 15
Lipopolysaccharide and interferon-gamma-induced nitric oxide production and protein oxidation in mouse peritoneal macrophages are affected by glutathione peroxidase-1 gene knockout.
2001 Aug 15
Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy.
2001 Aug 17
Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes.
2001 Feb
The phosphodiesterase inhibitors pentoxifylline and rolipram suppress macrophage activation and nitric oxide production in vitro and in vivo.
2001 Feb
Comparison of the effects of nitric oxide, nitroprusside, and nifedipine on hemodynamics and right ventricular contractility in patients with chronic pulmonary hypertension.
2001 Jan
Gastric mucosal resistance to acute injury in experimental portal hypertension.
2001 Jan
Ethanol inhibits cytokine-induced iNOS and sPLA2 in immortalized astrocytes: evidence for posttranscriptional site of ethanol action.
2001 Jan-Feb
15-Deoxy-delta12,14-PGJ2, but not troglitazone, modulates IL-1beta effects in human chondrocytes by inhibiting NF-kappaB and AP-1 activation pathways.
2001 Jul 13
Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced release of nitric oxide.
2001 Jul 31
Prostaglandins and nitric oxide mediate superoxide-induced myocardial contractile dysfunction in isolated rat hearts.
2001 Jun
Nitric oxide inhalation increases alveolar gas exchange by decreasing deadspace volume.
2001 Jun
Neonatal pulmonary hypertension--urea-cycle intermediates, nitric oxide production, and carbamoyl-phosphate synthetase function.
2001 Jun 14
Calcitonin gene-related peptide levels during nitric oxide-induced headache in patients with chronic tension-type headache.
2001 Mar
Expression of inducible nitric oxide synthase in primary culture of rat bladder smooth muscle cells by plasma from cyclophosphamide-treated rats.
2001 Mar 23
Sildenafil (viagra) facilitates weaning of inhaled nitric oxide following placement of a biventricular-assist device.
2001 May
Nitric oxide and chronic HCV and HIV infections.
2001 May
Patents

Patents

Sample Use Guides

20 ppm, maintained for up to 14 days or until the underlying oxygen desaturation has resolved
Route of Administration: Respiratory
In Vitro Use Guide
Curator's Comment:: In epithelial cells, NO increased apoptosis by 2.1 +/- 0.2-fold, augmented mRNA expression of Bax, and reduced expression of Bcl-2 compared with basal cultures. In stromal cells, NO increased cell proliferation in a dose-dependent manner, an effect that was blocked by a NO synthase inhibitor.
Unknown
Name Type Language
NITRIC OXIDE
EMA EPAR   EP   HSDB   JAN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
USAN  
Official Name English
NITRIC OXIDE [WHO-DD]
Common Name English
NITROGEN(II) OXIDE
Systematic Name English
NITROGEN OXIDE
Systematic Name English
NITRIC OXIDE [MART.]
Common Name English
NITROSYL RADICAL
Common Name English
NITRIC OXIDE [HSDB]
Common Name English
NITRIC OXIDE [EMA EPAR]
Common Name English
OHM-11771
Code English
INOVENT
Brand Name English
AMIDOGEN, OXO-
Brand Name English
NITRIC OXIDE [JAN]
Common Name English
NITRIC OXIDE [EP MONOGRAPH]
Common Name English
NITRIC OXIDE [MI]
Common Name English
NITRIC OXIDE [ORANGE BOOK]
Common Name English
NITRIC OXIDE [VANDF]
Common Name English
GENOSYL
Brand Name English
NITRIC OXIDE TRIMER
Common Name English
NITRIC OXIDE [USAN]
Common Name English
INOMAX
Brand Name English
NITROGEN MONOXIDE
Systematic Name English
NITROGEN OXIDE (NO)
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 603917
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
EU-Orphan Drug EU/3/15/1484
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
FDA ORPHAN DRUG 340811
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
FDA ORPHAN DRUG 368512
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
FDA ORPHAN DRUG 265708
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
FDA ORPHAN DRUG 551716
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
LOINC 74369-0
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
NDF-RT N0000175940
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
FDA ORPHAN DRUG 192104
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
FDA ORPHAN DRUG 638918
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
WHO-VATC QR07AX01
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
FDA ORPHAN DRUG 74493
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
FDA ORPHAN DRUG 621517
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
FDA ORPHAN DRUG 443914
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
FDA ORPHAN DRUG 551616
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
CFR 21 CFR 862.3080
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
NCI_THESAURUS C687
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
FDA ORPHAN DRUG 90595
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
FDA ORPHAN DRUG 193304
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
EMA ASSESSMENT REPORTS INOMAX (AUTHORIZED: RESPITORY INSUFFICIENCY, HYPERTENSION, PULMONARY)
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
FDA ORPHAN DRUG 403613
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
NDF-RT N0000009909
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
WHO-ATC R07AX01
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
DSLD 1699 (Number of products:1)
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
Code System Code Type Description
EVMPD
SUB12540MIG
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
PRIMARY
LACTMED
Nitric Oxide
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
PRIMARY
MERCK INDEX
M7934
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
PRIMARY Merck Index
RXCUI
7442
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
PRIMARY RxNorm
HSDB
1246
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
PRIMARY
DRUG BANK
DB00435
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
PRIMARY
NCI_THESAURUS
C695
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
PRIMARY
CAS
10102-43-9
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
PRIMARY
DRUG CENTRAL
1948
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
PRIMARY
ChEMBL
CHEMBL1200689
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
PRIMARY
EPA CompTox
10102-43-9
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
PRIMARY
IUPHAR
2509
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
PRIMARY
ECHA (EC/EINECS)
233-271-0
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
PRIMARY
WIKIPEDIA
NITRIC OXIDE
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
PRIMARY
PUBCHEM
145068
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
PRIMARY
EVMPD
SUB03447MIG
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
PRIMARY
MESH
D009569
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
PRIMARY
FDA UNII
31C4KY9ESH
Created by admin on Fri Jun 25 21:10:14 UTC 2021 , Edited by admin on Fri Jun 25 21:10:14 UTC 2021
PRIMARY