U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Showing 1 - 9 of 9 results

Status:
US Approved Rx (2003)
First approved in 1993

Class (Stereo):
CHEMICAL (ACHIRAL)



Torasemide is a pyridine-sulfonylurea type loop diuretic mainly used for the treatment of edema associated with congestive heart failure, renal disease, or hepatic disease. Also for the treatment of hypertension alone or in combination with other ant...
Status:
US Approved Rx (2025)
First approved in 1983

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Bumetanide is indicated for the treatment of edema associated with congestive heart failure, hepatic and renal disease, including the nephrotic syndrome. It blocks the reabsorption of sodium and fluid from the kidney's tubules. The most frequent clin...
Status:
US Approved Rx (2018)
First approved in 1967

Class (Stereo):
CHEMICAL (ACHIRAL)



Ethacrynic acid is a monosulfonamyl loop or high ceiling diuretic. Ethacrynic acid acts on the ascending limb of the loop of Henle and on the proximal and distal tubules. Urinary output is usually dose dependent and related to the magnitude of fluid ...
Status:
US Approved Rx (1982)
First approved in 1966

Class (Stereo):
CHEMICAL (ACHIRAL)



Furosemide, a sulfonamide-type loop diuretic structurally related to bumetanide, is used to manage hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome. Furosemide inhibits wa...
Status:
US Previously Marketed
First approved in 1979

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Ticrynafen, or tienilic acid, is a diuretic drug with uric acid-lowering action, formerly marketed for the treatment of hypertension. It was withdrawn from the market only months after its introduction because of reports of serious incidents of drug-...
Status:
Possibly Marketed Outside US
First approved in 2012

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)



Piretanide (INN, trade names Arelix, Eurelix, Tauliz) has been synthesized in 1973 at Hoechst AG (Germany) as a loop diuretic[2] compound by using a then-new method for introducing cyclic amine residues in an aromatic nucleus in the presence of other...
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (RACEMIC)


Etozolin is a diuretic used in Europe under the names Diulozin, Elkapin, Etopinil for the treatment of edema and hypertension. The exact mechanism of etozolin action is unknown. The current marketing status of the drug is unavailable and is supposed ...
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (RACEMIC)

MUZOLIMINE, a dichlorobenzene derivative, is a loop diuretic with slow effect and long lasting action. It was used for the treatment of hypertension but was withdrawn from the market because of severe neurological effects.