MUZOLIMINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C11H11Cl2N3O
Molecular Weight	272.131
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(N1N=C(N)CC1=O)C2=CC(Cl)=C(Cl)C=C2

InChI

InChIKey=RLWRMIYXDPXIEX-UHFFFAOYSA-N

InChI=1S/C11H11Cl2N3O/c1-6(16-11(17)5-10(14)15-16)7-2-3-8(12)9(13)4-7/h2-4,6H,5H2,1H3,(H2,14,15)

HIDE SMILES / InChI

Molecular Formula	C11H11Cl2N3O
Molecular Weight	272.131
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/68009156 | https://www.ncbi.nlm.nih.gov/pubmed/3449804 | https://www.ncbi.nlm.nih.gov/pubmed/1849334

MUZOLIMINE, a dichlorobenzene derivative, is a loop diuretic with slow effect and long lasting action. It was used for the treatment of hypertension but was withdrawn from the market because of severe neurological effects.

Approval Year

PubMed

Title	Date	PubMed
Muzolimine and nitrendipine in the treatment of arterial hypertension.	1985	3159163
The diuretic effect of muzolimine.	1987 Dec	3449804
Muzolimine-induced severe neuromyeloencephalopathy: report of seven cases.	1991 Jan	1849334

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:18:58 GMT 2023` Edited by `admin` on `Fri Dec 15 15:18:58 GMT 2023`
Record UNII	07Z36289ZX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MUZOLIMINE

Official Name

English

3-Amino-1-(3,4-dichloro-α-methylbenzyl)-2-pyrazolin-5-one

Systematic Name

English

muzolimine [INN]

Common Name

English

MUZOLIMINE [USAN]

Common Name

English

MUZOLIMINE [MI]

Common Name

English

3H-PYRAZOL-3-ONE, 5-AMINO-2-(1-(3,4-DICHLOROPHENYL)ETHYL)-2,4-DIHYDRO-

Systematic Name

English

3-AMINO-1-(3,4-DICHLORO-A-METHYLBENZYL)-2-PYRAZOLIN-5-ONE

Systematic Name

English

MUZOLIMINE [MART.]

Common Name

English

EDRUL

Brand Name

English

BAY G 2821

Code

English

BAY-G 2821

Code

English

Muzolimine [WHO-DD]

Common Name

English

BAY-G-2821

Code

English

Classification Tree Code System Code

WHO-ATC

C03CD01