MUZOLIMINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C11H11Cl2N3O
Molecular Weight	272.131
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MUZOLIMINE

Structure Search

SMILES

CC(N1N=C(N)CC1=O)C2=CC=C(Cl)C(Cl)=C2

InChI

InChIKey=RLWRMIYXDPXIEX-UHFFFAOYSA-N

InChI=1S/C11H11Cl2N3O/c1-6(16-11(17)5-10(14)15-16)7-2-3-8(12)9(13)4-7/h2-4,6H,5H2,1H3,(H2,14,15)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/68009156 | https://www.ncbi.nlm.nih.gov/pubmed/3449804 | https://www.ncbi.nlm.nih.gov/pubmed/1849334

MUZOLIMINE, a dichlorobenzene derivative, is a loop diuretic with slow effect and long lasting action. It was used for the treatment of hypertension but was withdrawn from the market because of severe neurological effects.

Approval Year

PubMed

PubMed

Title	Date	PubMed
Muzolimine-induced severe neuromyeloencephalopathy: report of seven cases.	1991-01	1849334
The diuretic effect of muzolimine.	1987-12	3449804
Muzolimine and nitrendipine in the treatment of arterial hypertension.	1985	3159163

Name

Type

Language

MUZOLIMINE

Official Name

English

EDRUL

Preferred Name

English

3-Amino-1-(3,4-dichloro-?-methylbenzyl)-2-pyrazolin-5-one

Systematic Name

English

muzolimine [INN]

Common Name

English

MUZOLIMINE [USAN]

Common Name

English

MUZOLIMINE [MI]

Common Name

English

3H-PYRAZOL-3-ONE, 5-AMINO-2-(1-(3,4-DICHLOROPHENYL)ETHYL)-2,4-DIHYDRO-

Systematic Name

English

3-AMINO-1-(3,4-DICHLORO-A-METHYLBENZYL)-2-PYRAZOLIN-5-ONE

Systematic Name

English

MUZOLIMINE [MART.]

Common Name

English

BAY G 2821

Code

English

BAY-G 2821

Code

English

Muzolimine [WHO-DD]

Common Name

English

BAY-G-2821

Code

English

Classification Tree Code System Code

WHO-ATC

C03CD01

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WHO-VATC

QC03CD01

Created by admin on Mon Mar 31 17:53:46 GMT 2025 , Edited by admin on Mon Mar 31 17:53:46 GMT 2025

Code System Code Type Description

SMS_ID

100000080603

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PUBCHEM

41386

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DRUG CENTRAL

1858

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WIKIPEDIA

MUZOLIMINE

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CAS

55294-15-0

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EPA CompTox

DTXSID50866476

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NCI_THESAURUS

C175151

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FDA UNII

07Z36289ZX

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MERCK INDEX

m836

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Merck Index

DRUG BANK

DB13801

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ECHA (EC/EINECS)

259-573-2

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ChEMBL

CHEMBL1697760

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EVMPD

SUB09097MIG

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INN

4119

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MESH

D009156

Created by admin on Mon Mar 31 17:53:46 GMT 2025 , Edited by admin on Mon Mar 31 17:53:46 GMT 2025

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ACTIVE MOIETY


					07Z36289ZX