U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C16H20N4O3S
Molecular Weight 348.42
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TORSEMIDE

SMILES

CC(C)NC(=O)NS(=O)(=O)C1=CN=CC=C1NC2=CC(C)=CC=C2

InChI

InChIKey=NGBFQHCMQULJNZ-UHFFFAOYSA-N
InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020136s023lbl.pdf

Torasemide is a pyridine-sulfonylurea type loop diuretic mainly used for the treatment of edema associated with congestive heart failure, renal disease, or hepatic disease. Also for the treatment of hypertension alone or in combination with other antihypertensive agents. It is also used at low doses for the management of hypertension. It is marketed under the brand name Demadex. Torasemide inhibits the Na+/K+/2Cl--carrier system (via interference of the chloride binding site) in the lumen of the thick ascending portion of the loop of Henle, resulting in a decrease in reabsorption of sodium and chloride. This results in an increase in the rate of delivery of tubular fluid and electrolytes to the distal sites of hydrogen and potassium ion secretion, while plasma volume contraction increases aldosterone production. The increased delivery and high aldosterone levels promote sodium reabsorption at the distal tubules, and by increasing the delivery of sodium to the distal renal tubule, torasemide indirectly increases potassium excretion via the sodium-potassium exchange mechanism. Torasemide's effects in other segments of the nephron have not been demonstrated. Thus torasemide increases the urinary excretion of sodium, chloride, and water, but it does not significantly alter glomerular filtration rate, renal plasma flow, or acid-base balance. Torasemide's effects as a antihypertensive are due to its diuretic actions. By reducing extracellular and plasma fluid volume, blood pressure is reduced temporarily, and cardiac output also decreases.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Demadex

Approved Use

Demadex is indicated for the treatment of edema associated with congestive heart failure, renal disease, or hepatic disease. Use of torsemide has been found to be effective for the treatment of edema associated with chronic renal failure. Demadex is indicated for the treatment of hypertension alone or in combination with other antihypertensive agents.

Launch Date

1993
Primary
Demadex

Approved Use

Demadex is indicated for the treatment of edema associated with congestive heart failure, renal disease, or hepatic disease. Use of torsemide has been found to be effective for the treatment of edema associated with chronic renal failure. Demadex is indicated for the treatment of hypertension alone or in combination with other antihypertensive agents.

Launch Date

1993
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
968.7 ng/mL
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TORSEMIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
1549.9 ng/mL
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TORSEMIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
1561 ng × h/mL
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TORSEMIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
3516 ng × h/mL
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TORSEMIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
4.4 h
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TORSEMIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
4.5 h
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TORSEMIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
1%
10 mg 1 times / day multiple, oral
dose: 10 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TORSEMIDE unknown
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
400 mg 1 times / day multiple, oral
Highest studied dose
Dose: 400 mg, 1 times / day
Route: oral
Route: multiple
Dose: 400 mg, 1 times / day
Sources: Page: p.124
unhealthy
Health Status: unhealthy
Condition: Chronic renal failure
Sources: Page: p.124
800 mg single, intravenous
Highest studied dose
Dose: 800 mg
Route: intravenous
Route: single
Dose: 800 mg
Sources: Page: p.124, 133
unhealthy
Health Status: unhealthy
Condition: Acute renal failure
Sources: Page: p.124, 133
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.11
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.11
Disc. AE: Dizziness, Headache...
AEs leading to
discontinuation/dose reduction:
Dizziness (0.1 - 0.5)
Headache (0.1 - 0.5)
Nausea (0.1 - 0.5)
Weakness (0.1 - 0.5)
Vomiting (0.1 - 0.5)
Hyperglycemia (0.1 - 0.5)
Urination abnormal NOS (0.1 - 0.5)
Hyperuricemia (0.1 - 0.5)
Hypokalemia (0.1 - 0.5)
Excessive thirst (0.1 - 0.5)
Hypovolemia (0.1 - 0.5)
Impotence (0.1 - 0.5)
Esophageal hemorrhage (0.1 - 0.5)
Dyspepsia (0.1 - 0.5)
Sources: Page: p.11
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.6
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.6
Disc. AE: Electrolyte depletion, Electrolyte depletion...
Other AEs: Hepatic coma, Tinnitus...
AEs leading to
discontinuation/dose reduction:
Electrolyte depletion
Electrolyte depletion
Hypokalemia
Other AEs:
Hepatic coma
Tinnitus
Hearing loss
Sources: Page: p.6
200 mg 1 times / day multiple, intravenous
Studied dose
Dose: 200 mg, 1 times / day
Route: intravenous
Route: multiple
Dose: 200 mg, 1 times / day
Sources:
unhealthy
n = 44
Health Status: unhealthy
Condition: Advanced chronic renal failure
Population Size: 44
Sources:
AEs

AEs

AESignificanceDosePopulation
Dizziness 0.1 - 0.5
Disc. AE
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.11
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.11
Dyspepsia 0.1 - 0.5
Disc. AE
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.11
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.11
Esophageal hemorrhage 0.1 - 0.5
Disc. AE
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.11
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.11
Excessive thirst 0.1 - 0.5
Disc. AE
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.11
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.11
Headache 0.1 - 0.5
Disc. AE
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.11
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.11
Hyperglycemia 0.1 - 0.5
Disc. AE
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.11
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.11
Hyperuricemia 0.1 - 0.5
Disc. AE
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.11
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.11
Hypokalemia 0.1 - 0.5
Disc. AE
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.11
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.11
Hypovolemia 0.1 - 0.5
Disc. AE
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.11
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.11
Impotence 0.1 - 0.5
Disc. AE
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.11
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.11
Nausea 0.1 - 0.5
Disc. AE
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.11
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.11
Urination abnormal NOS 0.1 - 0.5
Disc. AE
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.11
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.11
Vomiting 0.1 - 0.5
Disc. AE
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.11
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.11
Weakness 0.1 - 0.5
Disc. AE
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.11
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.11
Hearing loss
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.6
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.6
Hepatic coma
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.6
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.6
Tinnitus
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.6
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.6
Electrolyte depletion Disc. AE
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.6
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.6
Electrolyte depletion Disc. AE
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.6
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.6
Hypokalemia Disc. AE
200 mg 1 times / day multiple, oral (max)
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: multiple
Dose: 200 mg, 1 times / day
Sources: Page: p.6
unhealthy
Health Status: unhealthy
Condition: Edema associated with congestive heart failure, renal disease, or hepatic disease
Sources: Page: p.6
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer






Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
yes [Inhibition 100 uM]
yes [Inhibition 100 uM]
yes [Inhibition 100 uM]
Drug as victim
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Torasemide--a unique loop diuretic.
2001 Apr-May
Activity of a novel dual thromboxane A(2)receptor antagonist and thromboxane synthase inhibitor (BM-573) on platelet function and isolated smooth muscles.
2001 Aug
[Diuretics in heart failure. Can they also prolong life?].
2001 Dec 6
Simultaneous determination of torasemide and its major metabolite M5 in human urine by high-performance liquid chromatography-electrochemical detection.
2001 Nov
Optimal diuretic therapy for heart failure.
2001 Nov
Open-label randomized trial of torsemide compared with furosemide therapy for patients with heart failure.
2001 Nov
[Treatment of ascites in cirrhotic patients].
2001 Sep
[A better diuretic for patients with heart failure. Better control of potassium loss].
2002 Aug 8
Crystal forms of torasemide: new insights.
2002 Jan
[Which loop diuretic for heart failure? For prognosis the choices are not all the same].
2002 Oct 3
Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous torasemide in rats.
2003
[Torasemide (Trifas) in clinical practice--own experience].
2003
Ethacrynic acid and the sulfa-sensitive patient.
2003 Jan 13
[Favorable prognostic effect of heart failure therapy. Diuretic makes heart muscle more elastic].
2003 Jun 5
Effects of torasemide on left ventricular function and neurohumoral factors in patients with chronic heart failure.
2003 May
[Heart failure therapy. Cheap can become expensive].
2003 Oct 9
CYP2C9 polymorphisms and the interindividual variability in pharmacokinetics and pharmacodynamics of the loop diuretic drug torsemide.
2004 Dec
Torasemide inhibits transcardiac extraction of aldosterone in patients with congestive heart failure.
2004 Dec 7
Regulatory considerations of pharmaceutical solid polymorphism in Abbreviated New Drug Applications (ANDAs).
2004 Feb 23
Optimizing bacterial expression of catalytically active human cytochromes P450: comparison of CYP2C8 and CYP2C9.
2004 Jan
Effects of loop diuretics on myocardial fibrosis and collagen type I turnover in chronic heart failure.
2004 Jun 2
Differential contribution of active site residues in substrate recognition sites 1 and 5 to cytochrome P450 2C8 substrate selectivity and regioselectivity.
2004 Jun 22
[Idiopathic hypereosinophilia with cardiac involvement].
2004 Mar 12
High-Dose Torasemide is Equivalent to High-Dose Furosemide with Hypertonic Saline in the Treatment of Refractory Congestive Heart Failure.
2005
Screening procedure for detection of diuretics and uricosurics and/or their metabolites in human urine using gas chromatography-mass spectrometry after extractive methylation.
2005 Aug
[Aldosterone antagonist therapy for chronic heart failure].
2005 Feb 10
Dose-independent pharmacokinetics of torasemide after intravenous and oral administration to rats.
2005 Jul
Prediction of genotoxicity of chemical compounds by statistical learning methods.
2005 Jun
Comparison of the urine acidification tests of torsemide vs furosemide in healthy volunteers.
2005 Nov
Pharmacological profile and therapeutic potential of BM-573, a combined thromboxane receptor antagonist and synthase inhibitor.
2005 Spring
[A case of severe hyponatremia in a patient suffering from epilepsy and using oxcarbazepine].
2006
[Clinical efficacy and safety of administration of loop diuretic torasemide].
2006
Improved solid-phase extraction and HPLC measurement of torasemide and its important metabolites.
2006 Feb 2
Probable loop diuretic-induced pancreatitis in a sulfonamide-allergic patient.
2006 Jan
Cardiomyopathy, familial dilated.
2006 Jul 13
Gemcitabine in combination with EGF-Receptor antibody (Cetuximab) as a treatment of cholangiocarcinoma: a case report.
2006 Jul 17
Dose-dependent association between use of loop diuretics and mortality in advanced systolic heart failure.
2006 Nov 15
Efficacy and safety of a furosemide continuous infusion following cardiac surgery.
2006 Oct
Torsemide renal clearance and genetic variation in luminal and basolateral organic anion transporters.
2006 Sep
Hospital policies for treatment of acute decompensated heart failure.
2007 Apr
Gender difference in the pharmacokinetic interaction between oral warfarin and oxolamine in rats: inhibition of CYP2B1 by oxolamine in male rats.
2007 Apr
Torasemide transport by organic anion transporters contributes to hyperuricemia.
2007 Dec
Vasodilatory action of loop diuretics: a plethysmography study of endothelial function in forearm arteries and dorsal hand veins in hypertensive patients and controls.
2007 Feb
Effect of torsemide on serum and urine electrolyte levels in dogs with congestive heart failure.
2007 Jun 16
Loop diuretics in the management of acute renal failure: a systematic review and meta-analysis.
2007 Mar
Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs.
2007 Sep
Secondary pulmonary hypertension: haemodynamic effects of torasemide versus furosemide.
2008
Comparative effects of torasemide and furosemide in rats with heart failure.
2008 Feb 1
Torasemide, a long-acting loop diuretic, reduces the progression of myocarditis to dilated cardiomyopathy.
2008 Feb 26
The polymorphisms Asn130Asp and Val174Ala in OATP1B1 and the CYP2C9 allele *3 independently affect torsemide pharmacokinetics and pharmacodynamics.
2008 Jun
Patents

Sample Use Guides

Congestive Heart Failure The usual initial dose is 10 mg or 20 mg of once-daily oral Demadex (Torasemide). If the diuretic response is inadequate, the dose should be titrated upward by approximately doubling until the desired diuretic response is obtained. Single doses higher than 200 mg have not been adequately studied. Chronic Renal Failure The usual initial dose of Demadex is 20 mg of once-daily oral Demadex. Hypertension The usual initial dose is 5 mg once daily. If the 5 mg dose does not provide adequate reduction in blood pressure within 4 to 6 weeks, the dose may be increased to 10 mg once daily.
Route of Administration: Oral
Isometric contraction induced by a submaximal concentration of Ang II (10(-7) mol/L) was reduced in a dose-dependent way by torasemide (IC(50)=0.5+/-0.04 umol/L) in cultured vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats..
Name Type Language
TORSEMIDE
MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF  
USAN  
Official Name English
LUPRAC
Brand Name English
TORSEMIDE [MI]
Common Name English
TORSEMIDE [USAN]
Common Name English
TORSEMIDE [VANDF]
Common Name English
TORSEMIDE [USP MONOGRAPH]
Common Name English
TORASEMIDE [JAN]
Common Name English
1-ISOPROPYL-3-((4-M-TOLUIDINO-3-PYRIDYL)SULPHONYL)UREA
Systematic Name English
TORSEMIDE [ORANGE BOOK]
Common Name English
TORASEMIDE [EP MONOGRAPH]
Common Name English
torasemide [INN]
Common Name English
Torasemide [WHO-DD]
Common Name English
TORASEMIDE
INN   JAN   MART.   WHO-DD  
INN  
Official Name English
SOAANZ
Brand Name English
TORSEMIDE [USP-RS]
Common Name English
3-PYRIDINESULFONAMIDE, N-(((1-METHYLETHYL)AMINO)CARBONYL)-4-((3-METHYLPHENYL)AMINO)-
Systematic Name English
AC4464
Code English
AC-4464
Code English
TORASEMIDE [MART.]
Common Name English
BM02.015
Code English
BM-02015
Code English
UPCARD
Brand Name English
TORASEMIDE ANHYDROUS [EMA EPAR VETERINARY]
Common Name English
BM-02.015
Code English
TORASEMIDE ANHYDROUS
Common Name English
TORSEMIDE [USP IMPURITY]
Common Name English
Classification Tree Code System Code
WHO-VATC QC03CA04
Created by admin on Fri Dec 15 15:31:48 GMT 2023 , Edited by admin on Fri Dec 15 15:31:48 GMT 2023
LIVERTOX 984
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WHO-ATC C03CA04
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NDF-RT N0000175366
Created by admin on Fri Dec 15 15:31:48 GMT 2023 , Edited by admin on Fri Dec 15 15:31:48 GMT 2023
NCI_THESAURUS C49184
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EMA VETERINARY ASSESSMENT REPORTS UPCARD [AUTHORIZED]
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NDF-RT N0000175590
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Code System Code Type Description
RS_ITEM_NUM
1672304
Created by admin on Fri Dec 15 15:31:48 GMT 2023 , Edited by admin on Fri Dec 15 15:31:48 GMT 2023
PRIMARY
WIKIPEDIA
TORASEMIDE
Created by admin on Fri Dec 15 15:31:48 GMT 2023 , Edited by admin on Fri Dec 15 15:31:48 GMT 2023
PRIMARY
NCI_THESAURUS
C29506
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PRIMARY
DRUG BANK
DB00214
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PRIMARY
DAILYMED
W31X2H97FB
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PRIMARY
CAS
56211-40-6
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PRIMARY
DRUG CENTRAL
2708
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PRIMARY
ChEMBL
CHEMBL1148
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PRIMARY
EVMPD
SUB11195MIG
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PRIMARY
MESH
C026116
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PRIMARY
IUPHAR
7312
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PRIMARY
CHEBI
9637
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PRIMARY
RXCUI
38413
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PRIMARY RxNorm
INN
3938
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PRIMARY
EPA CompTox
DTXSID2023690
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PRIMARY
SMS_ID
100000090291
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PRIMARY
PUBCHEM
41781
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PRIMARY
MERCK INDEX
m10981
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PRIMARY Merck Index
LACTMED
Torsemide
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PRIMARY
FDA UNII
W31X2H97FB
Created by admin on Fri Dec 15 15:31:48 GMT 2023 , Edited by admin on Fri Dec 15 15:31:48 GMT 2023
PRIMARY