ETOZOLIN

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C13H20N2O3S
Molecular Weight	284.374
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

SMILES

CCOC(=O)\C=C1/SC(N2CCCCC2)C(=O)N1C

InChI

InChIKey=ZCKKHYXUQFTBIK-KTKRTIGZSA-N

InChI=1S/C13H20N2O3S/c1-3-18-11(16)9-10-14(2)12(17)13(19-10)15-7-5-4-6-8-15/h9,13H,3-8H2,1-2H3/b10-9-

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Description

Etozolin is a diuretic used in Europe under the names Diulozin, Elkapin, Etopinil for the treatment of edema and hypertension. The exact mechanism of etozolin action is unknown. The current marketing status of the drug is unavailable and is supposed to be discontinued.

Originator

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 575	Primary		Approved 8,583	ELKAPIN
Edema 23	Primary		Approved 8,583	ELKAPIN

F_unbound

F_unbound

Value	Dose	Co-administered	Analyte	Population
65%			ETOZOLIN unknown	Homo sapiens

Doses

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Dose	Population	Adverse events
200 mg 1 times / day multiple, oral Studied dose	unhealthy, ADULT	Other AEs: Weakness, Epigastric pain...

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AEs

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AE	Significance	Dose	Population
Headache	1.2%	200 mg 1 times / day multiple, oral Studied dose	unhealthy, ADULT
Dizziness	1.4%	200 mg 1 times / day multiple, oral Studied dose	unhealthy, ADULT
Constipation	1.7%	200 mg 1 times / day multiple, oral Studied dose	unhealthy, ADULT
Nausea	1.9%	200 mg 1 times / day multiple, oral Studied dose	unhealthy, ADULT
Epigastric pain	2.2%	200 mg 1 times / day multiple, oral Studied dose	unhealthy, ADULT

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PubMed

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Title	Date	PubMed
[Toxicological studies on Etozolin (author's transl)].	1977	578765
[Studies on the diuretic effects of etozolin (Elkapin) in heart failure - a comparison with the loop diuretic agent furosemide (author's transl)].	1979 Apr 20	460026

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Patents

Sample Use Guides

In Vivo Use Guide

The recommended dose is 200 mg/day.

Route of Administration: Oral

In Vitro Use Guide

Isolated rings of guinea-pig aorta were treated with etozolin (10 uM-1 mM). At those concentrations, the drug inhibited noradrenaline- and histamine-induced contractions. At very low concentrations (1 nM-0.1 uM), it inhibited also serotonin-induced contractions.

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Name

Type

Language

ELKAPIN

Preferred Name

English

ETOZOLIN

Official Name

English

ACETIC ACID, (3-METHYL-4-OXO-5-(1-PIPERIDINYL)-2-THIAZOLIDINYLIDENE)-, ETHYL ESTER

Common Name

English

ACETIC ACID, (3-METHYL-4-OXO-5-(1-PIPERIDINYL)-2-THIAZOLIDINYLIDENE)-, ETHYL ESTER, (Z)-

Systematic Name

English

ETHYL 3-METHYL-4-OXO-5-PIPERIDINO-.DELTA.2,.ALPHA.-THIAZOLIDINEACETATE

Common Name

English

Showing 1 to 5 of 19 entries

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Classification Tree

Code System

Code

Diuretic

NCI_THESAURUS

C49184

Other high-ceiling diuretics

WHO-ATC

C03CX01

Other high-ceiling diuretics

WHO-VATC

QC03CX01

Agent Affecting Cardiovascular System

NCI_THESAURUS

C270

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Code System

Code

Type

Description

NCI_THESAURUS

C65600

PRIMARY

ECHA (EC/EINECS)

200-794-0

PRIMARY

EVMPD

SUB07344MIG

PRIMARY

NSC

310039

PRIMARY

EPA CompTox

DTXSID40874489

PRIMARY

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ACTIVE MOIETY


					UEO8UW9V1Z

ETOZOLIN

METABOLITE ACTIVE (PARENT)


					55TIT7J81D

OZOLINONE

SMILES

InChI

Originator

Approval Year

Conditions

Funbound

Doses

AEs

PubMed

Patents

Sample Use Guides

F_unbound