U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 8951 - 8960 of 10061 results

Status:
Possibly Marketed Outside US
Source:
Japan:Piromidic Acid
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Piromidic acid, a quinolone antibiotic has an inhibitory effect against hepatic stages of P. falciparum and P. yoelii yoelii, and has a potential for treatment or prevention of malaria through their unique antiparasitic effect against erythrocytic and hepatic stages of Plasmodium.
Kainic acid (kainate) is a natural marine acid present in some seaweed. Kainic acid is a potent neuroexcitatory amino acid that acts by activating receptors for glutamate, the principal excitatory neurotransmitter in the central nervous system. Kainic acid is commonly injected into laboratory animal models to study the effects of experimental ablation. Kainic acid is a direct agonist of the glutamic kainate receptors and large doses of concentrated solutions produce immediate neuronal death by overstimulating neurons to death. Such damage and death of neurons is referred to as an excitotoxic lesion. Thus, in large, concentrated doses kainic acid can be considered a neurotoxin, and in small doses of dilute solution kainic acid will chemically stimulate neurons. Kainic acid is utilised in primary neuronal cell cultures and acute brain slice preparations [5] to study of the physiological effect of excitotoxicity and assess the neuroprotective capabilities of potential therapeutics. Kainic acid is a potent central nervous system excitant that is used in epilepsy research to induce seizures in experimental animals, at a typical dose of 10–30 mg/kg in mice. In addition to inducing seizures, kainic acid is excitotoxic and epileptogenic. Kainic acid induces seizures via activation of kainate receptors containing the GluK2 subunit and also through activation of AMPA receptors, for which it serves as a partial agonist.
Status:
Possibly Marketed Outside US
Source:
Japan:Protizinic Acid
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Protizinic acid is an elaborated member of propionic acid series, and is a cyclooxygenase inhibitor with antiinflammatory and antipyretic activity
Status:
Possibly Marketed Outside US
Source:
UK NHS:Strontium ranelate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Ranelic acid is an organic acid capable of chelating metal cations. Ranelic acid is an organic, highly polar molecule without pharmacological activity, its salt form, s, is a drug used to treat osteoporosis and increase bone mineral density
Status:
Possibly Marketed Outside US
Source:
NCT00357019: Phase 4 Interventional Completed Keratoconjunctivitis, Vernal
(2001)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Spaglumic acid (NAAG) is the β-aspartyl isoform of N-Acetyl-l-aspartylglutamate (isospaglumic Acid is N-(N-Acetyl-l-α-aspartyl)-l-glutamic acid). In eye drops, spaglumic acid is either a magnesium or sodium salt of N-Acetyl-l-aspartylglutamate. Spaglumic acid is a mast cell stabilizer. Thus it is used in allergic conditions such as allergic conjunctivitis. Specifically spaglumic acid is approved in Portugal under the brand name Naabak and in Greece under the brand name Naaxia for use in patients with allergic conjunctivitis. Spaglumic Acid is a peptide neurotransmitter and the third-most-prevalent neurotransmitter in the mammalian nervous system. It is a weak activator of NMDA receptors and a highly selective agonist for mGlu3 receptors. Spaglumic Acid is neuroprotective under non-hydrolysing conditions in vivo.
Status:
Possibly Marketed Outside US
Source:
NCT00357019: Phase 4 Interventional Completed Keratoconjunctivitis, Vernal
(2001)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


ISOSPAGLUMIC ACID is used as an antiallergic agent.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (RACEMIC)

Conditions:

There is no information related to the biological and pharmacological properties of the aleuritic acid. But is known, that this compound is is the major acid constituent of the lac resin secreted by Indian lac insect Kerria lacca. Also, it can be obtained from shellac by saponification. Aleuritic acid is a unique acid containing three hydroxyl groups of which two are of adjacent carbon atoms. It is used as a component in the perfume industry for the preparation of musk aroma.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Sultosilic acid is a benzenesulfonate ester. Sultosilic acid has been shown to be a hypolipidaemic drug both in animal experiments and in human clinical studies, chemically unrelated to other such drugs. The compound is being developed as a human drug (Mimedran ®) and is formulated as the piperazine salt (A-585). The recommended daily dose is three times one tablet containing 500 mg of Sultosilic acid.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ABSOLUTE)

Tauroselcholic acid Se-75 (SeHCAT) is an analog of naturally occurring bile acid conjugate taurocholic acid. It contains a radioactive isotope of selenium, which decays with a half-life of 120 days by emitting gamma-radiation. Tauroselcholic acid is used in clinical tests to diagnose bile acid malabsorption. This is achieved by determining either the excretion of activity in feces or the retention of the activity in the body over a period of days. Tauroselcholic acid is useful in the assessment of ileal involvement in, Crohn's disease, in assessing reduction of ileal absorptive function following certain surgical interventions and in assisting in the classification of patients suffering from chronic diarrhea.
Status:
Possibly Marketed Outside US
Source:
Xenyhexenic acid by ZYF Pharm Chemical
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Xenyhexenic acid is a biphenyl organic compound, discovered in 1958. When fed to rats, xenyhexenic acid inhibited hypercholesterolemia and hyperlipemia that been induced by the administration of Triton.

Showing 8951 - 8960 of 10061 results