Ranelic acid

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H10N2O8S
Molecular Weight	342.281
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CN(CC(O)=O)C1=C(C#N)C(CC(O)=O)=C(S1)C(O)=O

InChI

InChIKey=DJSXNILVACEBLP-UHFFFAOYSA-N

InChI=1S/C12H10N2O8S/c13-2-6-5(1-7(15)16)10(12(21)22)23-11(6)14(3-8(17)18)4-9(19)20/h1,3-4H2,(H,15,16)(H,17,18)(H,19,20)(H,21,22)

HIDE SMILES / InChI

Molecular Formula	C12H10N2O8S
Molecular Weight	342.281
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Assessment_Report_-_Variation/human/000560/WC500131789.pdf

Ranelic acid is an organic acid capable of chelating metal cations. Ranelic acid is an organic, highly polar molecule without pharmacological activity, its salt form, s, is a drug used to treat osteoporosis and increase bone mineral density

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Metal cations 1 Target ID: Metal cations Sources: http://www.trc-canada.com/product-detail/?CatNum=R120025&CAS=135459-90-4&Chemical_Name=Ranelic%20Acid&Mol_Formula=C12H10N2O8S&Synonym=5-%5BBis(carboxymethyl)amino%5D-2-carboxy-4-cyano-3-thiopheneacetic%20Acid;	Binding Agent 1076

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Gynaecological oncology perspective on management of the menopause.	2006-10	16698224
Glucocorticosteroid-induced spinal osteoporosis: scientific update on pathophysiology and treatment.	2006-07	16474946
Addressing and meeting the needs of osteoporotic patients with strontium ranelate: a review.	2006-06	16735842
Strontium ranelate: vertebral and non-vertebral fracture risk reduction.	2006-06	16735841
Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation.	2006-06	16735840
Efficacy and safety of alendronate and risedronate for postmenopausal osteoporosis.	2006-05	16709313
Preclinical assessment of gastrooesophageal tolerance of the new antiosteoporotic drug strontium ranelate: an endoscopic study in monkeys.	2006-05	16635101
Strontium ranelate for osteoporosis?	2006-04	16617933
Vertebral fracture risk reduction with strontium ranelate in women with postmenopausal osteoporosis is independent of baseline risk factors.	2006-04	16598373
Strontium ranelate--data on vertebral and nonvertebral fracture efficacy and safety: mechanism of action.	2006-03	16527006
Update of current therapeutic options for the treatment of postmenopausal osteoporosis.	2006-02	16678639
Anabolic agents: a new chapter in the management of osteoporosis.	2006-02	16643716
Strontium ranelate: the first dual acting treatment for postmenopausal osteoporosis.	2006-02	16462426
Strontium ranelate: an increased bone quality leading to vertebral antifracture efficacy at all stages.	2006-02	16455319
Strontium ranelate: a physiological approach for an improved bone quality.	2006-02	16455318
Fighting osteoporosis on two fronts.	2006-02	16442860
Strontium ranelate: a physiological approach for optimizing bone formation and resorption.	2006-02	16439191
Protelos: nonvertebral and hip antifracture efficacy in postmenopausal osteoporosis.	2006-02	16434247
[The latest developments in endocrinology 2004/2005].	2006-01-15	16418812
[Osteoporosis treatment].	2006-01-04	16465945
[Present development of new drugs for osteoporosis].	2006-01	16397369
[Strontium ranelate].	2006-01	16397364
The treatment of severe postmenopausal osteoporosis : a review of current and emerging therapeutic options.	2006	16396515
Strontium: new drug. Postmenopausal osteoporosis: too many unknowns.	2005-12	16397977
Newer drug treatments: their effects on fracture prevention.	2005-12	16301192
Strontium as therapy for osteoporosis.	2005-12	16183330
Cross-cultural validation and analysis of responsiveness of the QUALIOST: QUAlity of Life questionnaire In OSTeoporosis.	2005-11-10	16283929
[Strontium ranelate: a novel concept for the treatment of osteoporosis].	2005-11	16416353
[How to take charge of osteoporosis in women in 2005].	2005-11	16375239
Long-term effect of strontium ranelate treatment on BMD.	2005-11	16234961
Review of treatment modalities for postmenopausal osteoporosis.	2005-10	16295815
Effect of osteoporosis treatments on risk of non-vertebral fractures: review and meta-analysis of intention-to-treat studies.	2005-10	15986101
[Anabolic therapy of osteoporosis].	2005-09-17	16185635
[Strontium ranelate: a new therapeutic principle for postmenopausal osteoporosis].	2005-09-12	16159455
Long-term strontium ranelate administration in monkeys preserves characteristics of bone mineral crystals and degree of mineralization of bone.	2005-09	16059629
Osteoporosis.	2005-08	15911210
On some osteoporosis analyses.	2005-08	15864411
[Partnership between academic research and industry to study a new anti-osteoporotic drug].	2005-06-30	15985213
Strontium ranelate for the treatment of osteoporosis.	2005-06-18	15961793
Postmenopausal osteoporosis: therapeutic options.	2005-06	16096166
Where now for the management of osteoporosis?	2005-05	15920858
Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study.	2005-05	15728210
Strontium ranelate (Fujisawa/Servier).	2005-04	15898351
Strontium ranelate: a new treatment for postmenopausal osteoporosis with a dual mode of action.	2005-03	16036099
Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action on bone remodeling.	2005-02	15647810
[Osteoporosis].	2005-01-05	15773201
A new treatment for post-menopausal osteoporosis: strontium ranelate.	2005	16323829
Management of bone health in postmenopausal women.	2005	16286778
[Treatment of postmenopausal osteoporosis].	2004-12-15	15724589
[New treatments in osteoporosis].	2004-12	15841950

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:16:47 GMT 2025` Edited by `admin` on `Mon Mar 31 18:16:47 GMT 2025`
Record UNII	K9CCS0RIBT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Ranelic acid

Official Name

English

RANELIC ACID [MI]

Preferred Name

English

ranelic acid [INN]

Common Name

English

S12911

Code

English

Ranelic acid [WHO-DD]

Common Name

English

S-12911

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C62357