PROTIZINIC ACID

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H17NO3S
Molecular Weight	315.387
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C(C=C1)N(C)C3=C(S2)C=CC(=C3)C(C)C(O)=O

InChI

InChIKey=VSQMKHNDXWGCDB-UHFFFAOYSA-N

InChI=1S/C17H17NO3S/c1-10(17(19)20)11-4-7-15-14(8-11)18(2)13-6-5-12(21-3)9-16(13)22-15/h4-10H,1-3H3,(H,19,20)

HIDE SMILES / InChI

Description
Sources: I.K. Morton, Judith M. Hall Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp.342. P.238
Curator's Comment: Information on Protizinic acid is too limited. Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/7215998

Protizinic acid is an elaborated member of propionic acid series, and is a cyclooxygenase inhibitor with antiinflammatory and antipyretic activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
cyclooxygenase pathway 5 Target ID: GO:0019371 Sources: I.K. Morton, Judith M. Hall Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp.342. P.238 \| https://books.google.ru/books?id=tsjrCAAAQBAJ&pg=PA238&lpg=PA238&dq=17190+R.P.+drug&source=bl&ots=R3SxmEMrC9&sig=M44IyVrDHA7NFHF231nOTQlY32s&hl=ru&sa=X&ved=0ahUKEwj87oOuyaXPAhWJJJoKHeakBSsQ6AEIJTAB#v=onepage&q=17190&f=false	Inhibitor 8504
phospholipase A2 activity 1 Target ID: GO:0004623 Sources: http://www.ncbi.nlm.nih.gov/pubmed/6290356	Inhibitor 8504	21.0 mM [IC50]
platelet aggregation 80 Target ID: GO:0070527 Sources: http://www.ncbi.nlm.nih.gov/pubmed/7215998	Inhibitor 8504	0.555 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Inflammation 105 Sources: http://www.ncbi.nlm.nih.gov/pubmed/7215998,6290356	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Effects of protizinic acid on leukokinin generation and its physiological action.	1984-06	6475667
[Effects of protizinic acid on the prostaglandins system and the production of oxygen radicals].	1982-06	6290356
[Clinical study of the anti-inflammatory action of protizinic acid (17190 R.P.)].	1973-02	4542518

Patents

Sample Use Guides

In Vivo Use Guide

30 mg/kg (guinea pigs)

Route of Administration: Oral

In Vitro Use Guide

in vitro activity is reported in mM range (PLA2 activity IC50 21 mM, protein denaturation IC50 89 mM, platelet aggregation IC50 555 mM)

Name

Type

Language

PROTIZINIC ACID

Official Name

English

PIROCRID

Preferred Name

English

7-METHOXY-.ALPHA.,10-DIMETHYLPHENOTHIAZINE-2-ACETIC ACID

Systematic Name

English

Protizinic acid [WHO-DD]

Common Name

English

protizinic acid [INN]

Common Name

English

PROTIZINIC ACID [JAN]

Common Name

English

17190-RP

Code

English

10H-PHENOTHIAZINE-2-ACETIC ACID, 7-METHOXY-.ALPHA.,10-DIMETHYL-

Systematic Name

English

PROTIZINIC ACID [MART.]

Common Name

English

2-(7-METHOXY-10-METHYL-2-PHENOTHIAZINYL)PROPIONIC ACID

Systematic Name

English

PROTHIZINIC ACID

Common Name

English

PROTIZINIC ACID [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257