PIROMIDIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H16N4O3
Molecular Weight	288.3018
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN1C=C(C(O)=O)C(=O)C2=C1N=C(N=C2)N3CCCC3

InChI

InChIKey=RCIMBBZXSXFZBV-UHFFFAOYSA-N

InChI=1S/C14H16N4O3/c1-2-17-8-10(13(20)21)11(19)9-7-15-14(16-12(9)17)18-5-3-4-6-18/h7-8H,2-6H2,1H3,(H,20,21)

HIDE SMILES / InChI

Molecular Formula	C14H16N4O3
Molecular Weight	288.3018
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/12878530

Piromidic acid, a quinolone antibiotic has an inhibitory effect against hepatic stages of P. falciparum and P. yoelii yoelii, and has a potential for treatment or prevention of malaria through their unique antiparasitic effect against erythrocytic and hepatic stages of Plasmodium.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Malaria 95 Sources: http://www.ncbi.nlm.nih.gov/pubmed/12878530	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[Acute interstitial nephritis caused by drugs].	1983 May 20	6840011
Anti-toxoplasma activities of 24 quinolones and fluoroquinolones in vitro: prediction of activity by molecular topology and virtual computational techniques.	2000 Oct	10991859
Prediction of quinolone activity against Mycobacterium avium by molecular topology and virtual computational screening.	2000 Oct	10991858
Determination of quinolones and fluoroquinolones in fish tissue and seafood by high-performance liquid chromatography with electrospray ionisation tandem mass spectrometric detection.	2002 Dec 20	12489859
Determination of grepafloxacin and clinafloxacin by capillary zone electrophoresis.	2002 May 25	12016016
Square wave adsorptive stripping voltammetric determination of piromidic acid. Application in urine.	2003 Nov 24	14623580
Separation of fifteen quinolones by high performance liquid chromatography: application to pharmaceuticals and ofloxacin determination in urine.	2007 Jun	17623463
Trace analysis of quinolone and fluoroquinolone antibiotics from wastewaters by liquid chromatography-electrospray tandem mass spectrometry.	2008 Dec 19	19007934

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

piromidic acid was one of the most effective compounds with IC50 value 21.6 ug/ml against hepatic stages of P. yoelii yoelii

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:05:16 GMT 2023` Edited by `admin` on `Fri Dec 15 16:05:16 GMT 2023`
Record UNII	3I12WH4EWF
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PIROMIDIC ACID

Official Name

English

PIROMIDATE

Common Name

English

Piromidic acid [WHO-DD]

Common Name

English

piromidic acid [INN]

Common Name

English

PD-93

Code

English

PIROMIDIC ACID [MART.]

Common Name

English

PIROMIDIC ACID [MI]

Common Name

English

PIROMIDIC ACID [JAN]

Common Name

English

PANACID

Brand Name

English

NSC-291120

Code

English

Classification Tree Code System Code

WHO-ATC

J01MB03