U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C14H16N4O3
Molecular Weight 288.3018
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PIROMIDIC ACID

SMILES

CCN1C=C(C(O)=O)C(=O)C2=C1N=C(N=C2)N3CCCC3

InChI

InChIKey=RCIMBBZXSXFZBV-UHFFFAOYSA-N
InChI=1S/C14H16N4O3/c1-2-17-8-10(13(20)21)11(19)9-7-15-14(16-12(9)17)18-5-3-4-6-18/h7-8H,2-6H2,1H3,(H,20,21)

HIDE SMILES / InChI

Description

Piromidic acid, a quinolone antibiotic has an inhibitory effect against hepatic stages of P. falciparum and P. yoelii yoelii, and has a potential for treatment or prevention of malaria through their unique antiparasitic effect against erythrocytic and hepatic stages of Plasmodium.

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Basic research
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
[Acute interstitial nephritis caused by drugs].
1983 May 20
Anti-toxoplasma activities of 24 quinolones and fluoroquinolones in vitro: prediction of activity by molecular topology and virtual computational techniques.
2000 Oct
Prediction of quinolone activity against Mycobacterium avium by molecular topology and virtual computational screening.
2000 Oct
Square wave adsorptive stripping voltammetric determination of piromidic acid. Application in urine.
2003 Nov 24
Design, synthesis and activity against Toxoplasma gondii, Plasmodium spp., and Mycobacterium tuberculosis of new 6-fluoroquinolones.
2006 Dec
Genotoxic potential of quinolone antimicrobials in the in vitro comet assay and micronucleus test.
2006 Feb 28
Separation of fifteen quinolones by high performance liquid chromatography: application to pharmaceuticals and ofloxacin determination in urine.
2007 Jun
Multiresidue determination of quinolone and fluoroquinolone antibiotics in fish and shrimp by liquid chromatography/tandem mass spectrometry.
2007 Mar-Apr
Trace analysis of quinolone and fluoroquinolone antibiotics from wastewaters by liquid chromatography-electrospray tandem mass spectrometry.
2008 Dec 19
Patents

Patents

JPS56150016A
1

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
piromidic acid was one of the most effective compounds with IC50 value 21.6 ug/ml against hepatic stages of P. yoelii yoelii
Name Type Language
PIROMIDIC ACID
INN   JAN   MART.   MI   WHO-DD  
INN  
Official Name English
PIROMIDATE
Common Name English
Piromidic acid [WHO-DD]
Common Name English
piromidic acid [INN]
Common Name English
PD-93
Code English
PIROMIDIC ACID [MART.]
Common Name English
PIROMIDIC ACID [MI]
Common Name English
PIROMIDIC ACID [JAN]
Common Name English
PANACID
Brand Name English
NSC-291120
Code English
Classification Tree Code System Code
WHO-ATC J01MB03
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
NCI_THESAURUS C255
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
WHO-VATC QJ01MB03
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
NCI_THESAURUS C795
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID4045424
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
PRIMARY
WIKIPEDIA
Piromidic acid
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
PRIMARY
NCI_THESAURUS
C66433
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
PRIMARY
DRUG CENTRAL
2209
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
PRIMARY
ECHA (EC/EINECS)
243-161-4
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
PRIMARY
ChEMBL
CHEMBL311350
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
PRIMARY
MERCK INDEX
m8888
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
PRIMARY Merck Index
DRUG BANK
DB13744
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
PRIMARY
NSC
291120
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
PRIMARY
CHEBI
32019
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
PRIMARY
INN
3198
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
PRIMARY
FDA UNII
3I12WH4EWF
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
PRIMARY
MESH
D010893
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
PRIMARY
SMS_ID
100000081678
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
PRIMARY
EVMPD
SUB09934MIG
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
PRIMARY
CAS
19562-30-2
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
PRIMARY
PUBCHEM
4855
Created by admin on Fri Dec 15 16:05:16 GMT 2023 , Edited by admin on Fri Dec 15 16:05:16 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of PIROMIDIC ACID
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966