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Search results for nonoxynol root_version in Record Version (approximate match)
Status:
Possibly Marketed Outside US
Source:
M012
(2014)
Source URL:
First approved in 2014
Source:
M012
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Bornyl acetate is the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, which has displayed an anti-inflammatory effect. In addition was shown, that this compound had therapeutic potentials for the osteoarthritis and may be developed as a preventive agent for lung inflammatory diseases. In combination with 5-fluorouracil, bornyl acetate possesses the anticancer activity by inducing apoptosis, DNA fragmentation as well as G2/M cell cycle arrest.
Status:
Possibly Marketed Outside US
Source:
21 CFR 333A
(2012)
Source URL:
First approved in 2012
Source:
21 CFR 333A
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
Volu-Firm
Source URL:
First approved in 2011
Source:
Stem Cell Renew by Medon Co., Ltd
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Prezatide is a tripeptide molecule consisiting of lysine, glycine and histidine, also known as GHK (glycyl-L-histidyl-L-lysine), that forms a complex with copper ions. Prezatide is used in cosmetic products (skin and hair) and is known help wound healing. Prezatide increases the synthesis and deposition of type I collagen and glycosaminoglycan. It is thought to play a role in the modulation of tissue remodeling by increases the expression of matrix metalloproteinase-2, as well as tissue inhibitor of matrix metalloproteinases-1 and -2. Prezatide has antioxidant activity due to its ability to supply copper for superoxide dismutase and anti-inflammatory ability due to the blockage the of iron (Fe2+) release during injury.
Status:
Possibly Marketed Outside US
First approved in 2011
Source:
EnBrace HR by Jaymac Pharma
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Magnesium L-Threonate (MgT) is the most appropriate Mg salt that strengthens the cholinergic system and improves brain-related functions. It is used to improve memory, assist with sleep, and to enhance overall cognitive function. Mg, an intracellular cofactor for many enzymes, is a modulator of the N-methyl-D-aspartate (NMDA) receptor that is involved in memory function and depression. Experiments on rodents have shown that oral magnesium-L-Threonate also prevents neuropathic pain induced by chemotherapy.
Status:
Possibly Marketed Outside US
Source:
21 CFR 344
(2011)
Source URL:
First approved in 2011
Source:
21 CFR 344
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
NCT02469337: Phase 4 Interventional Unknown status Insulin Resistance
(2012)
Source URL:
First approved in 2011
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Dichloroacetic acid, often abbreviated DCA (dichloroacetate), is an acid analog of acetic acid in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms. The salts and esters of dichloroacetic acid are called dichloroacetates. Salts of DCA are used as drugs since they inhibit the enzyme pyruvate dehydrogenase kinase. Early reports of its activity against brain cancer cells led patients to treat themselves with DCA, which is commercially available in non-pharmaceutical grade. A phase 1 study in 5 patients concluded that DCA was safe, but wasn't designed to establish effectiveness.
DCA was approved for use in Canada in 1989 (as a topical formulation for the treatment of warts and for cauterization and removal of a wide variety of skin and tissue lesions), but was cancelled post market. DCA is a noncompetitive inhibitor of the endoplasmic reticulum enzyme HMG CoA reductase, which catalyzes the rate limiting step in cholesterol biosynthesis. DCA has been researched in adults, children, animals, and cells as a monotherapy as well as in
combination with other therapies for the treatment of severe metabolic disorders including diabetes and hypercholesterolemia, lactic acidosis, certain heart conditions, and cancer. DCA has been prescribed to reduce tumour size and tumour markers, prevent angiogenesis, reduce
cancer related symptoms, manage pain, and aid in palliation.
Status:
Possibly Marketed Outside US
Source:
NCT04677712: Phase 4 Interventional Completed Edematous Fibrosclerotic Panniculopathy (EFP)
(2020)
Source URL:
First approved in 2010
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Possibly Marketed Outside US
Source:
21 CFR 347
(2010)
Source URL:
First approved in 2010
Source:
21 CFR 347
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Nifurpipone is a nitrofuran with a large antimicrobial spectrum. Nifurpipone was shown to be a useful antibacterial agent in
urinary tract infections.
Status:
Possibly Marketed Outside US
Source:
21 CFR 333D
(2019)
Source URL:
First approved in 2010
Source:
21 CFR 356
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
M003
(2017)
Source URL:
First approved in 2009
Source:
21 CFR 333E
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)