THREONIC ACID, L-

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C4H8O5
Molecular Weight	136.1033
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC[C@H](O)[C@@H](O)C(O)=O

InChI

InChIKey=JPIJQSOTBSSVTP-STHAYSLISA-N

InChI=1S/C4H8O5/c5-1-2(6)3(7)4(8)9/h2-3,5-7H,1H2,(H,8,9)/t2-,3+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C4H8O5
Molecular Weight	136.1033
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6684626 | https://www.ncbi.nlm.nih.gov/pubmed/10420182 | http://www.hmdb.ca/metabolites/HMDB0000943https://www.ncbi.nlm.nih.gov/pubmed/28306698 | https://www.cancer.gov/publications/dictionaries/cancer-drug/def/magnesium-l-threonate | https://www.ncbi.nlm.nih.gov/pubmed/30829204

Magnesium L-Threonate (MgT) is the most appropriate Mg salt that strengthens the cholinergic system and improves brain-related functions. It is used to improve memory, assist with sleep, and to enhance overall cognitive function. Mg, an intracellular cofactor for many enzymes, is a modulator of the N-methyl-D-aspartate (NMDA) receptor that is involved in memory function and depression. Experiments on rodents have shown that oral magnesium-L-Threonate also prevents neuropathic pain induced by chemotherapy.

Approval Year

PubMed

Title	Date	PubMed
Neurobehavioral and biochemical effects of magnesium chloride (MgCl2), magnesium sulphate (MgSO4) and magnesium-L-threonate (MgT) supplementation in rats: A dose dependent comparative study.	2019-01	30829204
Defective methionine metabolism in the brain after repeated blast exposures might contribute to increased oxidative stress.	2018-01	28774719
Distinct metabolomic signature in cerebrospinal fluid in early parkinson's disease.	2017-10	28843022
Oral Application of Magnesium-L-Threonate Attenuates Vincristine-induced Allodynia and Hyperalgesia by Normalization of Tumor Necrosis Factor-α/Nuclear Factor-κB Signaling.	2017-06	28306698
Magnesium L-threonate prevents and restores memory deficits associated with neuropathic pain by inhibition of TNF-α.	2013-10-01	24077207
Chronic dietary magnesium-L-threonate speeds extinction and reduces spontaneous recovery of a conditioned taste aversion.	2013-05	23474371
Evaluation of a sunscreen photoprotective effect by ascorbic acid assessment in human dermis using microdialysis and gas chromatography mass spectrometry.	2005-03	15740589
Sugars including erythronic and threonic acids in human aqueous humour.	1999-08	10420182

Sample Use Guides

In Vivo Use Guide

When administered orally to guinea-pigs (100 mg/kg body weight) for periods of 4 or 28 days, sodium threonate (threonic acid) produced a significant fall in the ascorbic acid concentration of certain organs but was without effect on other physiological and biochemical characteristics. The lifespan of scorbutic guinea-pigs was significantly reduced by dietary threonic acid (100 mg/kg body weight)

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 20:16:27 GMT 2025` Edited by `admin` on `Mon Mar 31 20:16:27 GMT 2025`
Record UNII	75B0PMW2JF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

L-THREONATE

Preferred Name

English

THREONIC ACID, L-

Common Name

English

L-THREONIC ACID

Common Name

English

(2R,3S)-2,3,4-TRIHYDROXY-BUTANOIC ACID

Systematic Name

English

THREONATE

Common Name

English

Code System Code Type Description

FDA UNII

75B0PMW2JF