Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C12H20O2 |
Molecular Weight | 196.286 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)O[C@@H]1C[C@@H]2CC[C@@]1(C)C2(C)C
InChI
InChIKey=KGEKLUUHTZCSIP-HOSYDEDBSA-N
InChI=1S/C12H20O2/c1-8(13)14-10-7-9-5-6-12(10,4)11(9,2)3/h9-10H,5-7H2,1-4H3/t9-,10+,12+/m0/s1
Bornyl acetate is the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, which has displayed an anti-inflammatory effect. In addition was shown, that this compound had therapeutic potentials for the osteoarthritis and may be developed as a preventive agent for lung inflammatory diseases. In combination with 5-fluorouracil, bornyl acetate possesses the anticancer activity by inducing apoptosis, DNA fragmentation as well as G2/M cell cycle arrest.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: GO:1902749 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27061538 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Unknown Approved UseUnknown |
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Preventing | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
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[Study on the chemical constituents of the volatile oil from Lysimachia trientaloides Hemsl]. | 2002 May |
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An unusual and persistent contamination of drinking water by cutting oil. | 2003 Feb |
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Quality assessment of Flos Chrysanthemi Indici from different growing areas in China by solid-phase microextraction-gas chromatography-mass spectrometry. | 2004 Aug 27 |
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[Studies on the analgesic and anti-inflammatory effect of bornyl acetate in volatile oil from Amomum villosum]. | 2004 Jun |
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The effect of selected monoterpenoids on the cellular slime mold, Dictyostelium discoideum NC4. | 2004 Jun |
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Ion exchange resins as catalyst for the isomerization of alpha-pinene to camphene. | 2004 Jun |
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Essential oil of Valeriana officinalis L. cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation. | 2004 Jun 16 |
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Anticonvulsant activity and chemical composition of Artemisia dracunculus L. essential oil. | 2004 Oct |
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Chemical composition and antimicrobial activity of the essential oils of Chrysanthemum indicum. | 2005 Jan 4 |
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25 years of natural product R&D with New South Wales agriculture. | 2005 Oct 31 |
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Ethnoveterinary medicines used for ruminants in British Columbia, Canada. | 2007 Feb 26 |
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Terpenoid compositions, and antioxidant and antimicrobial properties of the rhizome essential oils of different Hedychium species. | 2008 Feb |
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GC/MS of terpenes in walnut-tree leaves after accelerated solvent extraction. | 2008 Jan |
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[Characterization of chemical components of essential oil from flowers of Chrysanthemum morifolium produced in Anhui province]. | 2008 Oct |
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Antinociceptive effect and GC/MS analysis of Rosmarinus officinalis L. essential oil from its aerial parts. | 2009 Apr |
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Acaricidal activities of major constituents of essential oil of Juniperus chinensis leaves against house dust and stored food mites. | 2009 Aug |
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Essential oil variability in natural populations of Picea omorika, a rare European conifer. | 2009 Feb |
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Composition and seasonal variation of the essential oil from Abies sachalinensis from Hokkaido, Japan. | 2009 Jun |
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Radical Scavenging Activity of the Essential Oil of Silver Fir (Abies alba). | 2009 May |
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Supercritical fluid extraction of the volatile oil from Santolina chamaecyparissus. | 2009 Sep |
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Antimicrobial activity and essential oil composition of a new T. argyrophyllum (C. Koch) Tvzel var. argyrophyllum chemotype. | 2010 |
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Compositional variability in essential oil from different parts of Alpinia speciosa from India. | 2010 Feb |
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Salvadora persica. | 2010 Jul |
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Effects of foliar fertilization and arbuscular mycorrhizal colonization on Salvia officinalis L. growth, antioxidant capacity, and essential oil composition. | 2010 Mar 15 |
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Relation between developmental stage, sensory properties, and volatile content of organically and conventionally grown pac choi (Brassica rapa var. Mei Qing Choi). | 2010 May |
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25545915
It was shown, that bornyl acetate elevated the expression of IL-11 at both the mRNA and protein levels. Normal human chondrocytes were pretreated with or without bornyl acetate at the concentrations of 50 and 100 ug/mL for 24H, followed by incubated with IL-1b 10 ug/mL for another 24 H.
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SUBSTANCE RECORD