Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C12H20O2 |
Molecular Weight | 196.286 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)O[C@@H]1C[C@@H]2CC[C@@]1(C)C2(C)C
InChI
InChIKey=KGEKLUUHTZCSIP-HOSYDEDBSA-N
InChI=1S/C12H20O2/c1-8(13)14-10-7-9-5-6-12(10,4)11(9,2)3/h9-10H,5-7H2,1-4H3/t9-,10+,12+/m0/s1
Molecular Formula | C12H20O2 |
Molecular Weight | 196.286 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Bornyl acetate is the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, which has displayed an anti-inflammatory effect. In addition was shown, that this compound had therapeutic potentials for the osteoarthritis and may be developed as a preventive agent for lung inflammatory diseases. In combination with 5-fluorouracil, bornyl acetate possesses the anticancer activity by inducing apoptosis, DNA fragmentation as well as G2/M cell cycle arrest.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: GO:1902749 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27061538 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Unknown Approved UseUnknown |
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Preventing | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Foliar and cortex oleoresin variability of silver fir (Abies alba Mill.) in Albania. | 2001 Jul-Aug |
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[Study on the chemical constituents of the volatile oil from Lysimachia trientaloides Hemsl]. | 2002 May |
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Analysis of the essential oils of the leaves, stems, rhizomes and roots of the medicinal plant Alpinia galanga from southern India. | 2003 Jun |
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Total synthesis of dumsin. 1. Retrosynthetic strategy and the elaboration of key intermediates from (--)-bornyl acetate. | 2003 Sep 5 |
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Essential oil of Valeriana officinalis L. cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation. | 2004 Jun 16 |
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[Profile-effect on quality control of Houttuynia cordata injection]. | 2005 Dec |
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[Research on the analgesic effect and mechanism of bornyl acetate in volatile oil from amomum villosum]. | 2005 Jun |
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Composition, enantiomeric distribution, and antibacterial activity of the essential oil of Achillea ligustica All. from Corsica. | 2006 Aug 23 |
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Chemical composition and biological activities of essential oil from the leaves of Sesuvium portulacastrum. | 2006 Jan 3 |
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Variation in chemical composition and antibacterial activities of essential oils from two species of Houttuynia THUNB. | 2006 Jul |
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Chemical composition and antimicrobial activity of the essential oil from Ambrosia trifida L. | 2006 Jul 25 |
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[Analysis of volatile constituents in leaves of three cypress species by gas chromatography/mass spectrometry]. | 2006 Mar |
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Phytochemical analysis of the essential oil of Achillea millefolium L. from various European Countries. | 2006 Oct |
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Chemical composition and antibacterial activities of the essential oil from Abies koreana. | 2007 Dec |
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Simultaneous distillation-extraction of high-value volatile compounds from Cistus ladanifer L. | 2007 Feb 19 |
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Ethnoveterinary medicines used for ruminants in British Columbia, Canada. | 2007 Feb 26 |
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Screening of antibacterial activities of twenty-one oxygenated monoterpenes. | 2007 Jul-Aug |
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Composition and enantiomeric analysis of the essential oil of the fruits and the leaves of Pistacia vera from Greece. | 2007 Jun 30 |
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Essential oil composition and antioxidant activity of aerial parts of Grindelia robusta from Central Italy. | 2007 Sep |
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Essential oil composition of Valeriana officinalis L. roots cultivated in Iran. Comparative analysis between supercritical CO2 extraction and hydrodistillation. | 2008 Feb 8 |
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GC/MS of terpenes in walnut-tree leaves after accelerated solvent extraction. | 2008 Jan |
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Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs. | 2008 Jun |
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Synthesis, chiroptical properties, and their theoretical simulation of some highly rotating benzotricamphor derivatives. | 2009 |
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Antimicrobial activity and essential oil composition of a new T. argyrophyllum (C. Koch) Tvzel var. argyrophyllum chemotype. | 2010 |
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Analysis of essential oils from different organs of Scutellaria baicalensis. | 2010 Aug |
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The chemical composition and antimicrobial activity of the leaf oil of Cupressus lusitanica from Monteverde, Costa Rica. | 2010 Jan |
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Misidentification of tansy, Tanacetum macrophyllum, as yarrow, Achillea grandifolia: a health risk or benefit? | 2010 Jan |
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Salvadora persica. | 2010 Jul |
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[Analysis of the chemical constituents of volatile oil from Asarum insigne by GC-MS]. | 2010 Jul |
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A DFT analysis of thermal decomposition reactions important to natural products. | 2010 Jul |
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The volatile constituents of Salvia leucantha. | 2010 Jun |
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Chemical composition and antibacterial activity of essential oils of Lantana camara, Ageratum houstonianum and Eupatorium adenophorum. | 2010 May |
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Relation between developmental stage, sensory properties, and volatile content of organically and conventionally grown pac choi (Brassica rapa var. Mei Qing Choi). | 2010 May |
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Genetics, phosphorus availability, and herbivore-derived induction as sources of phenotypic variation of leaf volatile terpenes in a pine species. | 2010 Oct |
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Volatile oil profiles of the aerial parts of Jordanian garland, Chrysanthemum coronarium. | 2010 Oct |
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Essential oils, phenolics, and antioxidant activities of different parts of cumin (Cuminum cyminum L.). | 2010 Oct 13 |
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25545915
It was shown, that bornyl acetate elevated the expression of IL-11 at both the mRNA and protein levels. Normal human chondrocytes were pretreated with or without bornyl acetate at the concentrations of 50 and 100 ug/mL for 24H, followed by incubated with IL-1b 10 ug/mL for another 24 H.
Substance Class |
Chemical
Created
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Record UNII |
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Record Status |
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