U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 801 - 810 of 16236 results

Status:
Investigational
Source:
INN:levoprotiline [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:thiotetrabarbital
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Thiotetrabarbital is a thiobarbituric acid derivative patented by "Centre national de la recherche scientifique" as a short-acting anesthetic agent useful in veterinary medicine.
Status:
Investigational
Source:
USAN:TIRBANIBULIN MESYLATE [USAN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:retelliptine [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Retelleptine (SR-95325 B) is an antitumoral agent. This ellipticine derivative exhibits high toxicity against several rodent tumor models. Retelliptine is thought to intercalate with DNA and inhibit topoisomerase II during DNA replication. A phase I study reported possible drug-related toxicity sporadically such as somnolence, bronchospasm, dry mouth, and vomiting.
Status:
Investigational
Source:
INN:salmisteine
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Salmisteine was studied as an antipyretic and mucolytic agent. Information about the current use of this compound is not available.
Status:
Investigational
Source:
INN:etisulergine
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Etisulergine (CQ 32-084) is an ergoline derivative. Etisulergine stimulates both dopamine D1- and D2-receptors, antagonizes alpha-adrenergic and serotonin 5-HT2 receptors. Etisulergine demonstrated antiparkinsonian activity in patients.
Status:
Investigational
Source:
NCT01877694: Phase 2 Interventional Completed Bacterial Conjunctivitis
(2013)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Auriclosene (previously known as NVC-422) is a broad-spectrum, fast-acting topical anti-infective agent against microbial pathogens, including antibiotic-resistant microbes. It has been investigated in phase II clinical trials for the treatment of bacterial conjunctivitis and as a topical gel in children with impetigo. In addition, using a guinea pig model was shown, that auriclosene was effective in the treatment of dermatophytosis, including onychomycosis.
Status:
Investigational
Source:
INN:hydroxytoluic acid
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Hydroxytoluic acid is a long-acting derivative of salicylate with antilipidemic properties. It shows fibrinolytic activity in human plasma by activating the fibrinolytic system and has been shown to lower plasma free fatty acid, cholesterol levels, and to raise metabolic oxygen consumption.
Status:
Investigational
Source:
INN:droclidinium bromide
Source URL:

Class (Stereo):
CHEMICAL (MIXED)

Droclidinium is the muscarinic receptors antagonist. It is an anticholinergic, spasmolytic agent.
Status:
Investigational
Source:
INN:nifuroquine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Nifuroquine is an antibacterial agent, used in the treatment of bovine mastitis.