Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C25H32N4O |
| Molecular Weight | 404.5478 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN(CC)CCCNC1=NC=CC2=C(C)C3=C(C4=CC(OC)=CC=C4N3)C(C)=C12
InChI
InChIKey=PAVKBQLPQCDVNI-UHFFFAOYSA-N
InChI=1S/C25H32N4O/c1-6-29(7-2)14-8-12-26-25-23-17(4)22-20-15-18(30-5)9-10-21(20)28-24(22)16(3)19(23)11-13-27-25/h9-11,13,15,28H,6-8,12,14H2,1-5H3,(H,26,27)
Retelleptine (SR-95325 B) is an antitumoral agent. This ellipticine derivative exhibits high toxicity against several rodent tumor models. Retelliptine is thought to intercalate with DNA and inhibit topoisomerase II during DNA replication. A phase I study reported possible drug-related toxicity sporadically such as somnolence, bronchospasm, dry mouth, and vomiting.
Approval Year
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C1968
Created by
admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
C73241
Created by
admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
|
PRIMARY | |||
|
C046349
Created by
admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
|
PRIMARY | |||
|
100000080553
Created by
admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
|
PRIMARY | |||
|
72238-02-9
Created by
admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
|
PRIMARY | |||
|
CHEMBL279890
Created by
admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
|
PRIMARY | |||
|
SZ0F94M68J
Created by
admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
|
PRIMARY | |||
|
DTXSID10222559
Created by
admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
|
PRIMARY | |||
|
68913
Created by
admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
|
PRIMARY | |||
|
6010
Created by
admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
|
PRIMARY | |||
|
SUB10289MIG
Created by
admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
|
PRIMARY | |||
|
276-512-5
Created by
admin on Fri Dec 15 16:20:39 GMT 2023 , Edited by admin on Fri Dec 15 16:20:39 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
