Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C25H32N4O |
| Molecular Weight | 404.5478 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN(CC)CCCNC1=NC=CC2=C1C(C)=C3C4=CC(OC)=CC=C4NC3=C2C
InChI
InChIKey=PAVKBQLPQCDVNI-UHFFFAOYSA-N
InChI=1S/C25H32N4O/c1-6-29(7-2)14-8-12-26-25-23-17(4)22-20-15-18(30-5)9-10-21(20)28-24(22)16(3)19(23)11-13-27-25/h9-11,13,15,28H,6-8,12,14H2,1-5H3,(H,26,27)
Retelleptine (SR-95325 B) is an antitumoral agent. This ellipticine derivative exhibits high toxicity against several rodent tumor models. Retelliptine is thought to intercalate with DNA and inhibit topoisomerase II during DNA replication. A phase I study reported possible drug-related toxicity sporadically such as somnolence, bronchospasm, dry mouth, and vomiting.
Approval Year
| Name | Type | Language | ||
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Preferred Name | English | ||
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Official Name | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C1968
Created by
admin on Mon Mar 31 18:25:37 GMT 2025 , Edited by admin on Mon Mar 31 18:25:37 GMT 2025
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C73241
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C046349
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100000080553
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72238-02-9
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CHEMBL279890
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SZ0F94M68J
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DTXSID10222559
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68913
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6010
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SUB10289MIG
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276-512-5
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PRIMARY |
ACTIVE MOIETY
