ETISULERGINE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H28N4O2S
Molecular Weight	376.516
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ETISULERGINE

Structure Search

SMILES

[H][C@@]12CC3=CNC4=CC=CC(=C34)[C@@]1([H])C[C@@H](CN2C)NS(=O)(=O)N(CC)CC

InChI

InChIKey=YHEIHLVIKSTGJE-YXJHDRRASA-N

InChI=1S/C19H28N4O2S/c1-4-23(5-2)26(24,25)21-14-10-16-15-7-6-8-17-19(15)13(11-20-17)9-18(16)22(3)12-14/h6-8,11,14,16,18,20-21H,4-5,9-10,12H2,1-3H3/t14-,16+,18+/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6267192 | https://www.ncbi.nlm.nih.gov/pubmed/6344587 | https://www.ncbi.nlm.nih.gov/pubmed/6311586 | https://www.ncbi.nlm.nih.gov/pubmed/3949149

Etisulergine (CQ 32-084) is an ergoline derivative. Etisulergine stimulates both dopamine D1- and D2-receptors, antagonizes alpha-adrenergic and serotonin 5-HT2 receptors. Etisulergine demonstrated antiparkinsonian activity in patients.

CNS Activity

Approval Year

PubMed

PubMed

Title	Date	PubMed
Selectivity of some ergot derivatives for 5-HT1 and 5-HT2 receptors of rat cerebral cortex.	1986	3949149

Name

Type

Language

ETISULERGINE

Official Name

English

N,N-DIETHYL-N'-(6-METHYLERGOLIN-8.ALPHA.-YL)SULFAMIDE

Systematic Name

English

etisulergine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66884

Created by admin on Fri Dec 15 16:20:14 GMT 2023 , Edited by admin on Fri Dec 15 16:20:14 GMT 2023

NCI_THESAURUS

C221

Created by admin on Fri Dec 15 16:20:14 GMT 2023 , Edited by admin on Fri Dec 15 16:20:14 GMT 2023

Code System Code Type Description

MESH

C031648

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ChEMBL

CHEMBL38992

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SMS_ID

100000082080

Created by admin on Fri Dec 15 16:20:14 GMT 2023 , Edited by admin on Fri Dec 15 16:20:14 GMT 2023

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FDA UNII

28N73Q6O7Y

Created by admin on Fri Dec 15 16:20:14 GMT 2023 , Edited by admin on Fri Dec 15 16:20:14 GMT 2023

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PUBCHEM

68847

Created by admin on Fri Dec 15 16:20:14 GMT 2023 , Edited by admin on Fri Dec 15 16:20:14 GMT 2023

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NCI_THESAURUS

C65582

Created by admin on Fri Dec 15 16:20:14 GMT 2023 , Edited by admin on Fri Dec 15 16:20:14 GMT 2023

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EVMPD

SUB07312MIG

Created by admin on Fri Dec 15 16:20:14 GMT 2023 , Edited by admin on Fri Dec 15 16:20:14 GMT 2023

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INN

5160

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CAS

64795-23-9

Created by admin on Fri Dec 15 16:20:14 GMT 2023 , Edited by admin on Fri Dec 15 16:20:14 GMT 2023

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EPA CompTox

DTXSID101024323

Created by admin on Fri Dec 15 16:20:14 GMT 2023 , Edited by admin on Fri Dec 15 16:20:14 GMT 2023

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ACTIVE MOIETY


					28N73Q6O7Y