RETELLIPTINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H32N4O
Molecular Weight	404.5478
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)CCCNC1=NC=CC2=C1C(C)=C3C4=CC(OC)=CC=C4NC3=C2C

InChI

InChIKey=PAVKBQLPQCDVNI-UHFFFAOYSA-N

InChI=1S/C25H32N4O/c1-6-29(7-2)14-8-12-26-25-23-17(4)22-20-15-18(30-5)9-10-21(20)28-24(22)16(3)19(23)11-13-27-25/h9-11,13,15,28H,6-8,12,14H2,1-5H3,(H,26,27)

HIDE SMILES / InChI

Molecular Formula	C25H32N4O
Molecular Weight	404.5478
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2386553 | https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf | https://www.sciencedirect.com/science/article/abs/pii/S0304383504007694

Retelleptine (SR-95325 B) is an antitumoral agent. This ellipticine derivative exhibits high toxicity against several rodent tumor models. Retelliptine is thought to intercalate with DNA and inhibit topoisomerase II during DNA replication. A phase I study reported possible drug-related toxicity sporadically such as somnolence, bronchospasm, dry mouth, and vomiting.

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:25:37 GMT 2025` Edited by `admin` on `Mon Mar 31 18:25:37 GMT 2025`
Record UNII	SZ0F94M68J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

retelliptine [INN]

Preferred Name

English

RETELLIPTINE

Official Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1968