ETISULERGINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H28N4O2S
Molecular Weight	376.516
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC3=CNC4=CC=CC(=C34)[C@@]1([H])C[C@@H](CN2C)NS(=O)(=O)N(CC)CC

InChI

InChIKey=YHEIHLVIKSTGJE-YXJHDRRASA-N

InChI=1S/C19H28N4O2S/c1-4-23(5-2)26(24,25)21-14-10-16-15-7-6-8-17-19(15)13(11-20-17)9-18(16)22(3)12-14/h6-8,11,14,16,18,20-21H,4-5,9-10,12H2,1-3H3/t14-,16+,18+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C19H28N4O2S
Molecular Weight	376.516
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6267192 | https://www.ncbi.nlm.nih.gov/pubmed/6344587 | https://www.ncbi.nlm.nih.gov/pubmed/6311586 | https://www.ncbi.nlm.nih.gov/pubmed/3949149

Etisulergine (CQ 32-084) is an ergoline derivative. Etisulergine stimulates both dopamine D1- and D2-receptors, antagonizes alpha-adrenergic and serotonin 5-HT2 receptors. Etisulergine demonstrated antiparkinsonian activity in patients.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
Neurochemical effects of some ergot derivatives: a basis for their antiparkinson actions.	1981	6267192
Treatment of Parkinson's disease with the ergoline derivatives CQ 32-084 and CU 32-085.	1983	6344587
The selectivity of some ergot derivatives for alpha 1 and alpha 2-adrenoceptors of rat cerebral cortex.	1983 Aug 5	6311586
Selectivity of some ergot derivatives for 5-HT1 and 5-HT2 receptors of rat cerebral cortex.	1986	3949149
Effects of the dopamine D2 agonists lisuride and CQ 32-084 on rat feeding behaviour.	1992 Apr	1350681
Behavioural profile in the chicken of CQ 32-084 and CQP 201-403, two dopamine agonists.	1993 May	8100070

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:20:14 GMT 2023` Edited by `admin` on `Fri Dec 15 16:20:14 GMT 2023`
Record UNII	28N73Q6O7Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ETISULERGINE

Official Name

English

N,N-DIETHYL-N'-(6-METHYLERGOLIN-8.ALPHA.-YL)SULFAMIDE

Systematic Name

English

etisulergine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66884