Details
Stereochemistry | ACHIRAL |
Molecular Formula | C8H8O3 |
Molecular Weight | 152.1473 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=C(O)C(=CC=C1)C(O)=O
InChI
InChIKey=WHSXTWFYRGOBGO-UHFFFAOYSA-N
InChI=1S/C8H8O3/c1-5-3-2-4-6(7(5)9)8(10)11/h2-4,9H,1H3,(H,10,11)
Hydroxytoluic acid is a long-acting derivative of salicylate with antilipidemic properties. It shows fibrinolytic activity in human plasma by activating the fibrinolytic system and has been shown to lower plasma free fatty acid, cholesterol levels, and to raise metabolic oxygen consumption.
Approval Year
PubMed
Title | Date | PubMed |
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Substituted alkyne synthesis under nonbasic conditions: copper carboxylate-mediated, palladium-catalyzed thioalkyne-boronic acid cross-coupling. | 2001 Jan 11 |
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[Anti-inflammatory activity of (o-cresotinate) copper and zinc aquacomplexes]. | 2002 Jul |
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Gene expression-based screening for inhibitors of PDGFR signaling. | 2008 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4932011
Diabetic geriatric patients received 900 mg Hydroxytoluic acid orally as a single dose or as a daily dose of up to 2.7g/day for 3 months. For patients receiving a single dose a 50 g glucose tolerance test was performed 2 hours after dosing, for longitudinal patients the glucose tolerance test was performed monthly or every two months. After a single 900 mg dose, plasma insulin levels showed considerable increases, plasma free fatty acid fell 2 hours after dosing with hydroxytoluic acid. Daily dosing of 1.8 g/day hydroxytoluic acid as the sole treatment allowed patients to control their diabetes but was not significantly different from controls. When added to the existing drug regimen patients receiving hydroxy toluic acid showed a smoothing of control of blood sugar with decreased needs of insulin or sulphonylurea.
Route of Administration:
Oral
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NCI_THESAURUS |
C29703
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3-Methylsalicylic acid
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6738
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ZH3HEY032H
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17561
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20141
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2117
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201-473-8
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SUB08087MIG
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DTXSID9038686
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C65873
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CHEMBL448399
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m3840
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100000083644
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83-40-9
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ACTIVE MOIETY