U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 671 - 680 of 919 results

Status:
US Previously Marketed
Source:
Spartase by Wyeth
(1961)
Source URL:
First marketed in 1921
Source:
potassium aspartate
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Disodium aspartate is used in organic biosynthesis.
Status:
US Previously Marketed
Source:
Sodium Cacodylate U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Sodium Cacodylate U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Targets:

Conditions:

Cacodylic acid also known as dimethylarsinic acid (DMA) has been used as a herbicide. As a part of agent blue it used to destroy broadleaf plants and trees, especially rice paddies during the Vietnam War. DMA is the major metabolite formed after exposure to tri- (arsenite) or pentavalent (arsenate) inorganic arsenic (iAs) via ingestion or inhalation in both humans and rodents. DMA induces an organ-specific lesion--single strand breaks in DNA. Mechanistic studies have suggested that this damage is due mainly to the peroxyl radical of DMA and production of active oxygen species by pulmonary tissues. Multi-organ initiation-promotion studies have demonstrated that DMA acts as a promotor of urinary bladder, kidney, liver and thyroid gland cancers in rats and as a promotor of lung tumors in mice. Thus it was shown, that DMA played a role in the carcinogenesis of inorganic arsenic.
Status:
US Previously Marketed
Source:
GALLOGEN ELLAGIC ACID by BEECHAM LABS
(1961)
Source URL:
First marketed in 1912

Class (Stereo):
CHEMICAL (ACHIRAL)



Ellagic acid is a dilactone of hexahydroxydiphenic acid, that found in numerous fruits and vegetables. Ellagic acid was first discovered by chemist Henri Braconnot in 1831. Ellagic acid is found in oaks species like the North American white oak (Quercus alba) and European red oak (Quercus robur). The highest levels of ellagic acid are found in walnuts, pecans, cranberries, raspberries, strawberries, and grapes, as well as distilled beverages. It is also found in peach, and other plant foods. Ellagic acid has antiproliferative and antioxidant properties in a number of in vitro and small-animal models. The antiproliferative properties of ellagic acid may be due to its ability to directly inhibit the DNA binding of certain carcinogens, including nitrosamines and polycyclic aromatic hydrocarbons. As with other polyphenol antioxidants, ellagic acid has a chemoprotective effect in cellular models by reducing oxidative stress. Ellagic acid is an investigational drug studied for treatment of Follicular Lymphoma (phase 2 trial), protection from brain injury of intrauterine growth restricted babies (phase 1 and 2 trial), improvement of cardiovascular function in adolescents who are obese (phase 2 trial), and topical treatment of solar lentigines. Ellagic acid has been marketed as a dietary supplement with a range of claimed benefits against cancer, heart disease, and other medical problems. Ellagic acid has been identified by the U.S. Food and Drug Administration as a "fake cancer 'cure' consumers should avoid".
Status:
US Previously Marketed
Source:
55 FR 33254 corn/callus remover phenoxyacetic acid
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Phenoxyacetic acid is found in cocoa and cocoa products. Phenoxyacetic acid is a flavouring ingredient. Phenoxyacetic acid is on the FDA list of approved food additives (PART 172 - FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION; Subpart F--Flavoring Agents and Related Substances Sec. 172.515 Synthetic flavoring substances and adjuvants.). Research has shown that Phenoxyacetic acid induced hematopoietic cell proliferation, providing potential for oral therapeutics which stimulate proliferation of hematopoietic cells of multiple lineages, as well as inducing fetal globin, important for therapy of hemoglobinopathies.
Status:
Possibly Marketed Outside US
Source:
EnLyte Extra-LN by Jaymac Pharmacueticals LLC
Source URL:
First approved in 2023

Class (Stereo):
CHEMICAL (ABSOLUTE)

3-Phenylpropionic acid (hydrocinnamic acid, HA) is an end-product of the bacterial degradation of unabsorbed phenylalanine in the intestinal lumen. HA is used in ice cream, drinks, and candy manufacture field as a flavoring agent. In recent years, HA is widely used in the pharmaceutical industry. Hydrocinnamic Acid inhibits the currents of WT and SQT3 syndrome-related mutants of Kir2.1 channel.
Status:
Possibly Marketed Outside US
First approved in 2022
Source:
Dr. Zonskin Nunssup Jara by J 1010 Co., Ltd.
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Aceneuramic acid (also known as N-Acetylneuraminic Acid, Neu5Ac, the UX 001 tablets) prolonged released had been filed a marketing authorization application with the European Medicines Agency by Ultragenyx in the EU for the treatment of hereditary inclusion body myopathy (HIBM), a rare, progressive muscle-wasting disease. This compound, a muscle protein stimulant, is also in phase II of the clinical trial for the treatment thrombocytopenia. In addition, recently was made studies, which had shown, that existed the significant positive correlation between serum and salivary sialic acid levels in oral squamous cell carcinoma (OSCC) patients.

Showing 671 - 680 of 919 results