Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H8O3 |
| Molecular Weight | 152.1473 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)COC1=CC=CC=C1
InChI
InChIKey=LCPDWSOZIOUXRV-UHFFFAOYSA-N
InChI=1S/C8H8O3/c9-8(10)6-11-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)
| Molecular Formula | C8H8O3 |
| Molecular Weight | 152.1473 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including
http://www.hmdb.ca/metabolites/HMDB31609 and http://www.ncbi.nlm.nih.gov/pubmed/9454687
Curator's Comment: Description was created based on several sources, including
http://www.hmdb.ca/metabolites/HMDB31609 and http://www.ncbi.nlm.nih.gov/pubmed/9454687
Phenoxyacetic acid is found in cocoa and cocoa products. Phenoxyacetic acid is a flavouring ingredient. Phenoxyacetic acid is on the FDA list of approved food additives (PART 172 - FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION; Subpart F--Flavoring Agents and Related Substances Sec. 172.515 Synthetic flavoring substances and adjuvants.). Research has shown that Phenoxyacetic acid induced hematopoietic cell proliferation, providing potential for oral therapeutics which stimulate proliferation of hematopoietic cells of multiple lineages, as well as inducing fetal globin, important for therapy of hemoglobinopathies.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The glutathione metabolism of the beta-lactam producer filamentous fungus Penicillium chrysogenum. | 2001 |
|
| Sodium hydrogen bis(phenoxyacetate). | 2001 Mar |
|
| Metal ion-dependent molecular inclusion chemistry: inclusion of aromatic anions by coordinated 1,4,7,10-tetrakis((S)-2-hydroxy-3-phenoxypropyl)-1,4,7,10-tetraazacyclododecane. | 2002 Mar 11 |
|
| Saccharomyces cerevisiae resistance to chlorinated phenoxyacetic acid herbicides involves Pdr1p-mediated transcriptional activation of TPO1 and PDR5 genes. | 2002 Mar 29 |
|
| Does the detoxification of penicillin side-chain precursors depend on microsomal monooxygenase and glutathione S-transferase in Penicillium chrysogenum? | 2003 |
|
| Pesticide exposure and birthweight: an epidemiological study in Central Poland. | 2003 |
|
| Formation of chloroacetic acids from soil, humic acid and phenolic moieties. | 2003 Jul |
|
| Theoretical studies on the gas-phase pyrolysis of 2-phenoxycarboxylic acids: an ONIOM approach. | 2003 Jun |
|
| [Identification and characterization of a plasmid in strain Aeronomas hydrophila IBRB-36 4CPA carrying genes for catabolism of chlorophenoxyacetic acids]. | 2004 Nov |
|
| Bioconjugatable porphyrins bearing a compact swallowtail motif for water solubility. | 2006 May-Jun |
|
| Uptake of pesticides from water by curly waterweed Lagarosiphon major and lesser duckweed Lemna minor. | 2007 Aug |
|
| Tetra-kis(μ-phenoxy-acetato-κO:O')bis-[(1,10-phenanthroline-κN,N')manganese(II)] methanol hemisolvate. | 2007 Dec 12 |
|
| Poly[[diaqua-nickel(II)]-μ(2)-4,4'-bipyridine-κN:N'-μ-p-phenyl-enedioxy-diacetato-κO:O']. | 2007 Dec 6 |
|
| Synthesis, characterization and antibacterial activity of azomethine derivatives derived from 2-formylphenoxyacetic acid. | 2007 Feb 22 |
|
| The role of laterally transferred genes in adaptive evolution. | 2007 Feb 8 |
|
| Agricultural exposures and gastric cancer risk in Hispanic farm workers in California. | 2007 Jun |
|
| Superheated water extraction and phase transfer methylation of phenoxy acid herbicides from solid matrices. | 2007 Jun 8 |
|
| Retention behavior of phenoxyacetic herbicides on a molecularly imprinted polymer with phenoxyacetic acid as a dummy template molecule. | 2007 Sep 15 |
|
| Structural Development Studies of Subtype-Selective Ligands for Peroxisome Proliferator-Activated Receptors (PPARs) Based on the 3,4-Disubstituted Phenylpropanoic Acid Scaffold as a Versatile Template. | 2008 |
|
| Analysis of phenoxyacetic acid herbicides as biomarkers in human urine using liquid chromatography/triple quadrupole mass spectrometry. | 2008 |
|
| Ultra-pressure liquid chromatography-electrospray tandem mass spectrometry for multiresidue determination of pesticides in water. | 2008 Aug 22 |
|
| Variation of MCPA, metribuzine, methyltriazine-amine and glyphosate degradation, sorption, mineralization and leaching in different soil horizons. | 2008 Dec |
|
| Synthesis and characterization of molecularly imprinted polymers for phenoxyacetic acids. | 2008 Jan |
|
| FT-IR, FT-Raman spectra and quantum chemical calculations of some chloro substituted phenoxy acetic acids. | 2008 Jul |
|
| Direct analysis of tfdA gene expression by indigenous bacteria in phenoxy acid amended agricultural soil. | 2008 Jun |
|
| Uptake of 4-chloro-2-methylphenoxyacetic acid (MCPA) from the apical membrane of Caco-2 cells by the monocarboxylic acid transporter. | 2008 Mar 15 |
|
| PPARδ activity in cardiovascular diseases: A potential pharmacological target. | 2009 |
|
| Automated potentiometric titrations in KCl/water-saturated octanol: method for quantifying factors influencing ion-pair partitioning. | 2009 Apr 1 |
|
| Optimization of the dilute maleic acid pretreatment of wheat straw. | 2009 Dec 21 |
|
| Allergic reaction induced by dermal and/or respiratory exposure to low-dose phenoxyacetic acid, organophosphorus, and carbamate pesticides. | 2009 Jul 10 |
|
| Uptake of phenoxyacetic acid derivatives into Caco-2 cells by the monocarboxylic acid transporters. | 2009 Sep 10 |
|
| Novel approaches to inhibition of gastric acid secretion. | 2010 Dec |
|
| Prior exposure to organophosphorus and organochlorine pesticides increases the allergic potential of environmental chemical allergens in a local lymph node assay. | 2010 Dec 15 |
|
| Comparative transcriptome profiling analyses during the lag phase uncover YAP1, PDR1, PDR3, RPN4, and HSF1 as key regulatory genes in genomic adaptation to the lignocellulose derived inhibitor HMF for Saccharomyces cerevisiae. | 2010 Nov 24 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 14:59:30 GMT 2023
by
admin
on
Fri Dec 15 14:59:30 GMT 2023
|
| Record UNII |
YRC253429Q
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
JECFA EVALUATION |
PHENOXYACETIC ACID
Created by
admin on Fri Dec 15 14:59:30 GMT 2023 , Edited by admin on Fri Dec 15 14:59:30 GMT 2023
|
||
|
CFR |
21 CFR 172.515
Created by
admin on Fri Dec 15 14:59:30 GMT 2023 , Edited by admin on Fri Dec 15 14:59:30 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
C415326
Created by
admin on Fri Dec 15 14:59:30 GMT 2023 , Edited by admin on Fri Dec 15 14:59:30 GMT 2023
|
PRIMARY | |||
|
C45678
Created by
admin on Fri Dec 15 14:59:30 GMT 2023 , Edited by admin on Fri Dec 15 14:59:30 GMT 2023
|
CONCEPT | Industrial Aid | ||
|
DTXSID9025873
Created by
admin on Fri Dec 15 14:59:30 GMT 2023 , Edited by admin on Fri Dec 15 14:59:30 GMT 2023
|
PRIMARY | |||
|
204-556-7
Created by
admin on Fri Dec 15 14:59:30 GMT 2023 , Edited by admin on Fri Dec 15 14:59:30 GMT 2023
|
PRIMARY | |||
|
122-59-8
Created by
admin on Fri Dec 15 14:59:30 GMT 2023 , Edited by admin on Fri Dec 15 14:59:30 GMT 2023
|
PRIMARY | |||
|
C84049
Created by
admin on Fri Dec 15 14:59:30 GMT 2023 , Edited by admin on Fri Dec 15 14:59:30 GMT 2023
|
PRIMARY | |||
|
YRC253429Q
Created by
admin on Fri Dec 15 14:59:30 GMT 2023 , Edited by admin on Fri Dec 15 14:59:30 GMT 2023
|
PRIMARY | |||
|
19188
Created by
admin on Fri Dec 15 14:59:30 GMT 2023 , Edited by admin on Fri Dec 15 14:59:30 GMT 2023
|
PRIMARY | |||
|
m8636
Created by
admin on Fri Dec 15 14:59:30 GMT 2023 , Edited by admin on Fri Dec 15 14:59:30 GMT 2023
|
PRIMARY | Merck Index | ||
|
Phenoxyacetic acid
Created by
admin on Fri Dec 15 14:59:30 GMT 2023 , Edited by admin on Fri Dec 15 14:59:30 GMT 2023
|
PRIMARY | |||
|
8075
Created by
admin on Fri Dec 15 14:59:30 GMT 2023 , Edited by admin on Fri Dec 15 14:59:30 GMT 2023
|
PRIMARY | |||
|
1426335
Created by
admin on Fri Dec 15 14:59:30 GMT 2023 , Edited by admin on Fri Dec 15 14:59:30 GMT 2023
|
PRIMARY | RxNorm | ||
|
9810
Created by
admin on Fri Dec 15 14:59:30 GMT 2023 , Edited by admin on Fri Dec 15 14:59:30 GMT 2023
|
PRIMARY | |||
|
38846
Created by
admin on Fri Dec 15 14:59:30 GMT 2023 , Edited by admin on Fri Dec 15 14:59:30 GMT 2023
|
PRIMARY | |||
|
959
Created by
admin on Fri Dec 15 14:59:30 GMT 2023 , Edited by admin on Fri Dec 15 14:59:30 GMT 2023
|
PRIMARY | |||
|
1426336
Created by
admin on Fri Dec 15 14:59:30 GMT 2023 , Edited by admin on Fri Dec 15 14:59:30 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
SALT/SOLVATE -> PARENT |
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
|
||
|
PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
|
||
|
PARENT -> IMPURITY |
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
|
