Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H21N7O6 |
| Molecular Weight | 443.4133 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=N2)N1
InChI
InChIKey=OZRNSSUDZOLUSN-LBPRGKRZSA-N
InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Developing a dynamic pharmacophore model for HIV-1 integrase. | 2000 Jun 1 |
|
| Preliminary application of liquid chromatography-electrospray-ionization mass spectrometry to the detection of 5-methyltetrahydrofolic acid monoglutamate in human plasma. | 2001 Dec 25 |
|
| Molecular action of methotrexate in inflammatory diseases. | 2002 |
|
| Role of water in the catalytic cycle of E. coli dihydrofolate reductase. | 2002 Jun |
|
| Hydride transfer during catalysis by dihydrofolate reductase from Thermotoga maritima. | 2003 Sep 1 |
|
| Sodium-dependent methotrexate carrier-1 is expressed in rat kidney: cloning and functional characterization. | 2004 Mar |
|
| Microscale synthesis of isotopically labeled R-[6-xH]N5,N10-methylene-5,6,7,8-tetrahydrofolate as a cofactor for thymidylate synthase. | 2004 May 1 |
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| Methotrexate enhances the anti-inflammatory effect of CF101 via up-regulation of the A3 adenosine receptor expression. | 2006 |
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| Experimental characterization of Cis-acting elements important for translation and transcription in halophilic archaea. | 2007 Dec |
|
| catena-Poly[bis-(sulfamethoxazolium) [[trichloridocadmate(II)]-μ-chlorido] monohydrate]. | 2007 Dec 21 |
|
| Role of airway lactoperoxidase in scavenging of hydrogen peroxide damage in asthma. | 2007 Jul |
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| Adenosine in inflammatory joint diseases. | 2007 Mar |
|
| Metabolism of halophilic archaea. | 2008 Mar |
|
| (E)-N'-(3,3-Diphenyl-allyl-idene)-p-toluene-sulfonohydrazide. | 2009 Apr 18 |
|
| A mapping of drug space from the viewpoint of small molecule metabolism. | 2009 Aug |
|
| Antimicrobial evaluation of novel substituted pyrimidinopyrazoles and pyrimidinotriazoles. | 2010 Apr |
|
| Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition. | 2010 Jul |
|
| Cobalamin deficiency, hyperhomocysteinemia, and dementia. | 2010 May 6 |
|
| [Photobiochemistry of folates: a photochemical reduction of folic acid]. | 2010 May-Jun |
|
| A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. | 2012 |
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135398604
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23743
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DB02015
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DTXSID401027140
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165989
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15633
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KXP0KNM559
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4033-27-6
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2267573
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KXP0KNM559
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Dihydrofolic acid
Created by
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SUBSTANCE RECORD
