Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H21N7O6 |
| Molecular Weight | 443.4133 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=N2)N1
InChI
InChIKey=OZRNSSUDZOLUSN-LBPRGKRZSA-N
InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Developing a dynamic pharmacophore model for HIV-1 integrase. | 2000 Jun 1 |
|
| Preliminary application of liquid chromatography-electrospray-ionization mass spectrometry to the detection of 5-methyltetrahydrofolic acid monoglutamate in human plasma. | 2001 Dec 25 |
|
| Molecular action of methotrexate in inflammatory diseases. | 2002 |
|
| Reaction-path energetics and kinetics of the hydride transfer reaction catalyzed by dihydrofolate reductase. | 2003 Nov 25 |
|
| Hydride transfer during catalysis by dihydrofolate reductase from Thermotoga maritima. | 2003 Sep 1 |
|
| Folate requirements of the 2-keto-L-gulonic acid-producing strain Ketogulonigenium vulgare LMP P-20356 in L-sorbose/CSL medium. | 2004 Aug |
|
| Sodium-dependent methotrexate carrier-1 is expressed in rat kidney: cloning and functional characterization. | 2004 Mar |
|
| Kinetics of the inhibition of bovine liver dihydrofolate reductase by tea catechins: origin of slow-binding inhibition and pH studies. | 2005 May 24 |
|
| Methotrexate enhances the anti-inflammatory effect of CF101 via up-regulation of the A3 adenosine receptor expression. | 2006 |
|
| Sulfonamides in the environment as veterinary drugs. | 2006 |
|
| Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent manner. | 2006 Jun |
|
| A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users. | 2007 Apr |
|
| Experimental characterization of Cis-acting elements important for translation and transcription in halophilic archaea. | 2007 Dec |
|
| Role of airway lactoperoxidase in scavenging of hydrogen peroxide damage in asthma. | 2007 Jul |
|
| Ligand binding and circular permutation modify residue interaction network in DHFR. | 2007 Jun |
|
| Adenosine in inflammatory joint diseases. | 2007 Mar |
|
| Metabolism of halophilic archaea. | 2008 Mar |
|
| Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo. | 2008 Mar 5 |
|
| (E)-N'-(5-Chloro-2-hydroxy-benzyl-idene)-p-toluene-sulfonohydrazide. | 2008 Nov 22 |
|
| Regulation of translation in haloarchaea: 5'- and 3'-UTRs are essential and have to functionally interact in vivo. | 2009 |
|
| (E)-N'-(3,3-Diphenyl-allyl-idene)-p-toluene-sulfonohydrazide. | 2009 Apr 18 |
|
| (E)-N'-(4-Chloro-benzyl-idene)-p-toluene-sulfonohydrazide 0.15-hydrate. | 2009 Apr 25 |
|
| A mapping of drug space from the viewpoint of small molecule metabolism. | 2009 Aug |
|
| QM/MM study of thymidylate synthase: enzymatic motions and the temperature dependence of the rate limiting step. | 2009 Mar 12 |
|
| Management of Pneumocystis Jirovecii pneumonia in HIV infected patients: current options, challenges and future directions. | 2010 |
|
| Antimicrobial evaluation of novel substituted pyrimidinopyrazoles and pyrimidinotriazoles. | 2010 Apr |
|
| Dynamic subcellular localization of isoforms of the folate pathway enzyme serine hydroxymethyltransferase (SHMT) through the erythrocytic cycle of Plasmodium falciparum. | 2010 Dec 3 |
|
| Complete genomic sequence of bacteriophage felix o1. | 2010 Mar |
|
| Cobalamin deficiency, hyperhomocysteinemia, and dementia. | 2010 May 6 |
|
| A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. | 2012 |
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
135398604
Created by
admin on Sat Dec 16 01:35:08 UTC 2023 , Edited by admin on Sat Dec 16 01:35:08 UTC 2023
|
PRIMARY | |||
|
23743
Created by
admin on Sat Dec 16 01:35:08 UTC 2023 , Edited by admin on Sat Dec 16 01:35:08 UTC 2023
|
PRIMARY | |||
|
DB02015
Created by
admin on Sat Dec 16 01:35:08 UTC 2023 , Edited by admin on Sat Dec 16 01:35:08 UTC 2023
|
PRIMARY | |||
|
DTXSID401027140
Created by
admin on Sat Dec 16 01:35:08 UTC 2023 , Edited by admin on Sat Dec 16 01:35:08 UTC 2023
|
PRIMARY | |||
|
165989
Created by
admin on Sat Dec 16 01:35:08 UTC 2023 , Edited by admin on Sat Dec 16 01:35:08 UTC 2023
|
PRIMARY | |||
|
15633
Created by
admin on Sat Dec 16 01:35:08 UTC 2023 , Edited by admin on Sat Dec 16 01:35:08 UTC 2023
|
PRIMARY | |||
|
KXP0KNM559
Created by
admin on Sat Dec 16 01:35:08 UTC 2023 , Edited by admin on Sat Dec 16 01:35:08 UTC 2023
|
PRIMARY | |||
|
4033-27-6
Created by
admin on Sat Dec 16 01:35:08 UTC 2023 , Edited by admin on Sat Dec 16 01:35:08 UTC 2023
|
PRIMARY | |||
|
2267573
Created by
admin on Sat Dec 16 01:35:08 UTC 2023 , Edited by admin on Sat Dec 16 01:35:08 UTC 2023
|
PRIMARY | |||
|
KXP0KNM559
Created by
admin on Sat Dec 16 01:35:08 UTC 2023 , Edited by admin on Sat Dec 16 01:35:08 UTC 2023
|
PRIMARY | |||
|
Dihydrofolic acid
Created by
admin on Sat Dec 16 01:35:08 UTC 2023 , Edited by admin on Sat Dec 16 01:35:08 UTC 2023
|
PRIMARY |
SUBSTANCE RECORD
