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Restrict the search for
dimethyl fumarate
to a specific field?
Status:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Candocuronium is bisquaternary aza steroid derivative with neuromuscular blocking, ganglion blocking, and vagolytic activities. Its potential adjunctive use in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation was briefly evaluated in clinical studies in India, but further development discontinued because of attendant cardiovascular effects, primarily tachycardia that was no worse than but also not an improvement over the clinically established pancuronium bromide.
Status:
Class (Stereo):
CHEMICAL (RACEMIC)
Status:
Investigational
Source:
NCT03951337: Phase 2 Interventional Active, not recruiting Rectal Cancer
(2019)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
ATSM CU-64 is an agent for imaging hypoxia in tissues. The agent was developed to be used in PET diagnostic imaging of cancer and showed positive results in phase II of clinical trials in patients with cervical cancer.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Nemadectin (LL-F28249-a) is a macrocyclic lactone antibiotic demonstrating broad-spectrum endectocidal and nematocidal activity. Nemadectin, the dominant member of a class of milbemycins bearing unsaturated longer chain group at the C25 position, is commonly used as a starting material for the commercial anthelmintic moxidectin.
Class (Stereo):
CHEMICAL (ACHIRAL)
Indolidan is 2-indolinone derivative patented by American pharmaceutical company Eli Lilly and Co as inotropic agents useful for the treatment of heart failure. Indolidan acts as a phosphodiesterase III inhibitor and decreased the thrombin-induced increase endothelial permeability.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Mebolazine is an androgenic anabolic steroid.
Status:
Investigational
Class (Stereo):
CHEMICAL (UNKNOWN)
Ganglefene is a coronary vasodilator. This n-cholinoblocker was originally studied for its effects on coronary circulation in angina pectoris. Animal studies have also shown shortened recovery period of motor functions after ganglefene administration. One rodent study showed that modulation of the n-cholinergic system by ganglefene in the developing fetal brain leads to changes in the quantitative and qualitative characteristics of elements of sexual behavior in pubescent offspring.
Status:
Investigational
Source:
NCT03414034: Phase 2 Interventional Completed Metastatic Castration-Resistant Prostate Cancer
(2018)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
NMS-P937 is a selective PLK1 inhibitor. It was developed by Nerviano Medical Sciences and tested in phase I clinical trials.
Status:
Investigational
Source:
NCT01750957: Phase 2 Interventional Completed Fragile X Syndrome
(2013)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Basimglurant is a potent, selective, and safe mGlu5 inhibitor with good oral bioavailability and long half-life supportive of once-daily administration, good brain penetration, and high in vivo potency. It has antidepressant properties that are corroborated by its functional magnetic imaging profile as well as anxiolytic-like and antinociceptive features. In electroencephalography recordings, basimglurant shows wake-promoting effects followed by increased delta power during subsequent non-rapid eye movement sleep. Basimglurant has favorable drug-like properties, a differentiated molecular mechanism of action, and antidepressant-like features that suggest the possibility of also addressing important comorbidities of MDD including anxiety and pain as well as daytime sleepiness and apathy or lethargy. Basimglurant is being under development by Roche for the treatment of treatment-resistant depression (as an adjunct). It is in phase II clinical trials for this indication.
Status:
Investigational
Source:
NCT00659802: Phase 2 Interventional Completed Ulcerative Colitis
(2008)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Andrographolide, a diterpenoid, is known for its anti-inflammatory effects. It can be isolated from various plants of the genus Andrographis, commonly known as 'creat'. Andrographolide has been tested for its anti-inflammatory effects in various stressful conditions, such as ischemia, pyrogenesis, arthritis, hepatic or neural toxicity, carcinoma, and oxidative stress. Apart from its anti-inflammatory effects, andrographolide also exhibits immunomodulatory effects by effectively enhancing cytotoxic T cells, natural killer (NK) cells, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC). The properties of andrographolide, such as its ability to induce apoptosis of cancer cells and inhibition of DTH, its anti-oxidative and cytoprotective effect, and its ability to enhance CTLs and NK cell activation makes it a potent antiviral agent. Andrographolide inhibited the growth of human breast, prostate, and hepatoma tumors. Andrographolide could be a potent anticancer agent when used in combination with other chemotherapeutic agents.
