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Restrict the search for
dimethyl fumarate
to a specific field?
Status:
Investigational
Source:
NCT03833362: Phase 3 Interventional Completed Hepatitis C
(2014)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Narlaprevir (formerly SCH 900518), a NS3 protease inhibitor is being developed by R-Pharm for the treatment of a chronic hepatitis C (genotype 1). Narlaprevir is a potent inhibitor of hepatitis C virus (HCV) NS3 protease with a Ki of 7 ± 1 nM and a 90% inhibitory concentration (IC90) of ∼28 ng/ml for HCV genotype 1 replicon in vitro. Narlaprevir successfully passed extensive pre-clinical and clinical trials in Schering-Plough Research Institute (USA) and in a variety of clinical centers of Europe, USA and Russia. Based on clinical findings R-Pharm obtained a registration certificate for Arlansa (Narlaprevir) ЛП-003622 dd 12.05.2016 issued by Ministry of Healthcare of the Russian Federation.
Status:
Investigational
Source:
NCT00655369: Phase 2 Interventional Completed Nonrestorative Sleep
(2008)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Atagabalin, also known as PD-0200390, was studied in phase II clinical trials in patients with primary insomnia, but this trial was discontinued because of the unsatisfied results. Atagabalin is a ligand to the α(2)δ subunit of voltage-sensitive calcium channels
Class (Stereo):
CHEMICAL (RACEMIC)
Gemazocine is an opioid antagonist. It was first reported in the literature in the 1970’s, and toxicology studies have been performed to characterize its profile.
Status:
Investigational
Source:
USAN:ONVANSERTIB FUMARATE [USAN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Class (Stereo):
CHEMICAL (RACEMIC)
Volazocine was studied as an analgesic. Information about the current use of this agent is not available.
Status:
Investigational
Class (Stereo):
CHEMICAL (RACEMIC)
Oxiramide, an antiarrhythmic agent was studied as a cardiac depressant. However, information about the current use of this compound is not available.
Class (Stereo):
CHEMICAL (UNKNOWN)
Menabitan is a synthetic cannabinoid exerting analgesic activity.
Status:
Investigational
Source:
NCT00820079: Phase 2 Interventional Completed Gastroesophageal Reflux
(2008)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
ADX 10059 is a first-in-class reflux inhibitor that works by reducing activation of the metabotropic glutamate receptor 5 (mGluR5) through negative allosteric modulation (NAM). This approach may lead to a new class of drugs that addresses the causes of GERD rather than just the symptoms. ADX 10059 is a potent selective NAM of the mGluR5, with
an IC50 of 17.1 nM on hmGluR5 showing good selectivity
compared with > 65 other receptors, transporters, ion
channels and enzymes. ADX 10059 completed Phase IIb testing in gastroesophageal reflux disease (GERD) and migraine prevention, demonstrated significant potential in a non-human primate model of Parkinson's disease levodopa induced dyskinesia (PD-LID). However, Addex Pharmaceuticals announced the discontinuation of development of ADX 10059 in December 2009 due to liver enzyme changes.
Class (Stereo):
CHEMICAL (RACEMIC)
Gamfexine (WIN 1344) was introduced in the literature in 1966 as an anti-depressant. Although it was reported to be effective in the treatment of withdrawal in schizophrenia, it worsened psychotic symptoms.
Status:
Class (Stereo):
CHEMICAL (RACEMIC)
