GAMFEXINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H27N
Molecular Weight	245.403
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CCC(C1CCCCC1)C2=CC=CC=C2

InChI

InChIKey=AJDSHXKJJDQZCJ-UHFFFAOYSA-N

InChI=1S/C17H27N/c1-18(2)14-13-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3,5-6,9-10,16-17H,4,7-8,11-14H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C17H27N
Molecular Weight	245.403
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/Gamfexine | https://en.wikipedia.org/wiki/Gamfexine
Curator's Comment: 3 Pubmed ID's, but are title only

Gamfexine (WIN 1344) was introduced in the literature in 1966 as an anti-depressant. Although it was reported to be effective in the treatment of withdrawal in schizophrenia, it worsened psychotic symptoms.

Approval Year

PubMed

Title	Date	PubMed
Preclinical-clinical correlation of anti-depressant activity: controlled study of gamfexine and imipramine.	1967 Jul	4963162
A controlled study of the effects of gamfexine in phenothiazine-treated patients.	1970 Apr	4985944

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:46:56 GMT 2023` Edited by `admin` on `Fri Dec 15 16:46:56 GMT 2023`
Record UNII	3U2V80KPAL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GAMFEXINE

Official Name

English

WIN-1344

Code

English

gamfexine [INN]

Common Name

English

N,N-Dimethyl-γ-phenylcyclohexanepropylamine

Systematic Name

English

WIN 1344

Code

English

GAMFEXINE [USAN]

Common Name

English

BENZENEPROPANAMINE, .GAMMA.-CYCLOHEXYL-N,N-DIMETHYL-

Systematic Name

English

Code System Code Type Description

NCI_THESAURUS

C166697