INDOLIDAN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H15N3O2
Molecular Weight	257.2878
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1(C)C(=O)NC2=C1C=C(C=C2)C3=NNC(=O)CC3

InChI

InChIKey=LZCQFJKUAIWHRW-UHFFFAOYSA-N

InChI=1S/C14H15N3O2/c1-14(2)9-7-8(3-4-11(9)15-13(14)19)10-5-6-12(18)17-16-10/h3-4,7H,5-6H2,1-2H3,(H,15,19)(H,17,18)

HIDE SMILES / InChI

Molecular Formula	C14H15N3O2
Molecular Weight	257.2878
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8405786 | https://www.ncbi.nlm.nih.gov/pubmed/1446958

Indolidan is 2-indolinone derivative patented by American pharmaceutical company Eli Lilly and Co as inotropic agents useful for the treatment of heart failure. Indolidan acts as a phosphodiesterase III inhibitor and decreased the thrombin-induced increase endothelial permeability.

Originator

Approval Year

PubMed

Title	Date	PubMed
Cardiovascular effects of NSP-804 and NSP-805, novel cardiotonic agents with vasodilator properties.	1993-06	7687727

Patents

Sample Use Guides

In Vivo Use Guide

15 micrograms/kg

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:39:28 GMT 2025` Edited by `admin` on `Mon Mar 31 18:39:28 GMT 2025`
Record UNII	0751ZOW7OR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LY 195115

Preferred Name

English

INDOLIDAN

Official Name

English

3,3-Dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2-indolinone

Systematic Name

English

LY-195115

Code

English

INDOLIDAN [USAN]

Common Name

English

2H-INDOL-2-ONE, 1,3-DIHYDRO-3,3-DIMETHYL-5-(1,4,5,6-TETRAHYDRO-6-OXO-3-PYRIDAZINYL)-

Systematic Name

English

indolidan [INN]

Common Name

English

Code System Code Type Description

ChEMBL

CHEMBL38224