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Details

Stereochemistry ACHIRAL
Molecular Formula C8H14N6S2.Cu
Molecular Weight 322.297
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 4
Charge 0

SHOW SMILES / InChI
Structure of ATSM COPPER (II) CU-64

SMILES

[64Cu++].CN\C([S-])=N\N=C(C)\C(C)=N\N=C(/[S-])NC

InChI

InChIKey=SBHDKYTVDCRMOE-NLRRAJSESA-L
InChI=1S/C8H16N6S2.Cu/c1-5(11-13-7(15)9-3)6(2)12-14-8(16)10-4;/h1-4H3,(H2,9,13,15)(H2,10,14,16);/q;+2/p-2/b11-5+,12-6+;/i;1+0

HIDE SMILES / InChI
Molecular Formula Cu
Molecular Weight 63.929767865
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C8H16N6S2
Molecular Weight 260.383
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 2
Optical Activity NONE

Description

ATSM CU-64 is an agent for imaging hypoxia in tissues. The agent was developed to be used in PET diagnostic imaging of cancer and showed positive results in phase II of clinical trials in patients with cervical cancer.

CNS Activity

Originator

Approval Year

Unknown
149124
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Phase II
1147
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
Wikidata
Q27289429
PubMed

PubMed

TitleDatePubMed
Pre-clinical Positron Emission Tomography Reconstruction Algorithm Effect on Cu-64 ATSM Lesion Hypoxia.
2016-02-05
Copper-64 radiopharmaceuticals for PET imaging of cancer: advances in preclinical and clinical research.
2009-08
Comparative studies of Cu-64-ATSM and C-11-acetate in an acute myocardial infarction model: ex vivo imaging of hypoxia in rats.
1999-01

Sample Use Guides

In Vivo Use Guide
In a clinical study, ATSM CU-64 was intravenously injected as a single dose of 925 MBq.
Route of Administration: Intravenous
In Vitro Use Guide
EMT6 Cells were equilibrated and 7.4 MBq (200 uCi) (0.15 ug) ATSM CU-64 were added. The percentage of uptake was 80% after 1 h.
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:40:31 GMT 2025
Edited
by admin
on Mon Mar 31 18:40:31 GMT 2025
Record UNII
SW5KMQ68KN
Record Status Validated (UNII)
Record Version
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Name Type Language
64CU DIACETYLBIS(N4-METHYLTHIOSEMICARBAZONE)
Preferred Name English
ATSM COPPER (II) CU-64
Common Name English
ATSM CU-64
Common Name English
ATSM COPPER CU-64
Common Name English
COPPER-64CU, ((2,2'-(1,2-DIMETHYL-1,2-ETHANEDIYLIDENE)BIS(N-METHYLHYDRAZINECARBOTHIOAMIDATO-.KAPPA.N2,.KAPPA.S))(2-))-, (SP-4-2)-
Systematic Name English
Code System Code Type Description
CAS
213531-97-6
Created by admin on Mon Mar 31 18:40:31 GMT 2025 , Edited by admin on Mon Mar 31 18:40:31 GMT 2025
PRIMARY
PUBCHEM
91668168
Created by admin on Mon Mar 31 18:40:31 GMT 2025 , Edited by admin on Mon Mar 31 18:40:31 GMT 2025
PRIMARY
FDA UNII
SW5KMQ68KN
Created by admin on Mon Mar 31 18:40:31 GMT 2025 , Edited by admin on Mon Mar 31 18:40:31 GMT 2025
PRIMARY
Related Record Type Details
Structure of ATSM COPPER (II)
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