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Details

Stereochemistry ACHIRAL
Molecular Formula C8H14N6S2.Cu
Molecular Weight 322.297
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 4
Charge 0

SHOW SMILES / InChI
Structure of ATSM COPPER (II) CU-64

SMILES

[64Cu++].CN\C([S-])=N\N=C(C)\C(C)=N\N=C(/[S-])NC

InChI

InChIKey=SBHDKYTVDCRMOE-NLRRAJSESA-L
InChI=1S/C8H16N6S2.Cu/c1-5(11-13-7(15)9-3)6(2)12-14-8(16)10-4;/h1-4H3,(H2,9,13,15)(H2,10,14,16);/q;+2/p-2/b11-5+,12-6+;/i;1+0

HIDE SMILES / InChI
Molecular Formula C8H16N6S2
Molecular Weight 260.383
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 2
Optical Activity NONE
Molecular Formula Cu
Molecular Weight 63.9298
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

ATSM CU-64 is an agent for imaging hypoxia in tissues. The agent was developed to be used in PET diagnostic imaging of cancer and showed positive results in phase II of clinical trials in patients with cervical cancer.

CNS Activity

Originator

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Phase II
1132
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
Wikidata
Q27289429
PubMed

PubMed

TitleDatePubMed
Comparative studies of Cu-64-ATSM and C-11-acetate in an acute myocardial infarction model: ex vivo imaging of hypoxia in rats.
1999 Jan
Copper-64 radiopharmaceuticals for PET imaging of cancer: advances in preclinical and clinical research.
2009 Aug
Pre-clinical Positron Emission Tomography Reconstruction Algorithm Effect on Cu-64 ATSM Lesion Hypoxia.
2016 Feb 5

Sample Use Guides

In Vivo Use Guide
In a clinical study, ATSM CU-64 was intravenously injected as a single dose of 925 MBq.
Route of Administration: Intravenous
In Vitro Use Guide
EMT6 Cells were equilibrated and 7.4 MBq (200 uCi) (0.15 ug) ATSM CU-64 were added. The percentage of uptake was 80% after 1 h.
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:06:02 GMT 2023
Edited
by admin
on Fri Dec 15 17:06:02 GMT 2023
Record UNII
SW5KMQ68KN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ATSM COPPER (II) CU-64
Common Name English
ATSM CU-64
Common Name English
64CU DIACETYLBIS(N4-METHYLTHIOSEMICARBAZONE)
Common Name English
ATSM COPPER CU-64
Common Name English
COPPER-64CU, ((2,2'-(1,2-DIMETHYL-1,2-ETHANEDIYLIDENE)BIS(N-METHYLHYDRAZINECARBOTHIOAMIDATO-.KAPPA.N2,.KAPPA.S))(2-))-, (SP-4-2)-
Systematic Name English
Code System Code Type Description
CAS
213531-97-6
Created by admin on Fri Dec 15 17:06:02 GMT 2023 , Edited by admin on Fri Dec 15 17:06:02 GMT 2023
PRIMARY
PUBCHEM
91668168
Created by admin on Fri Dec 15 17:06:02 GMT 2023 , Edited by admin on Fri Dec 15 17:06:02 GMT 2023
PRIMARY
FDA UNII
SW5KMQ68KN
Created by admin on Fri Dec 15 17:06:02 GMT 2023 , Edited by admin on Fri Dec 15 17:06:02 GMT 2023
PRIMARY
Related Record Type Details
Structure of ATSM COPPER (II)
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