U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Status:
US Previously Marketed
Source:
ALLECUR 40MG by ROERIG
(1961)
Source URL:
First approved in 1960
Source:
Allercur by Roerig (Pfizer)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Clemizole is a drug in clinical development for the treatment of hepatitis C virus (HCV) infection. Clemizole is a novel inhibitor of TRPC5 channels. Clemizole is an H1 antagonist. Clemizole, an antihistamine drug that was once widely used for treatment of allergic disease, was recently discovered to be a potent inhibitor (IC50, 24 nM) of the interaction between an HCV protein (NS4B) and HCV RNA. Although clemizole was widely used during the 1950s and 1960s, this was before contemporary regulatory requirements were established for new drug development, and there is very minimal information about its pharmacokinetics and metabolism.
Status:
US Previously Marketed
Source:
KECTIL DIHYDROSTREPTOMYCIN SULFATE by BRISTOL LABS
(1961)
Source URL:
First approved in 1948
Source:
Dihydrostreptomycin Sulfate by Merck
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Dihydrostreptomycin is an antibiotic compound derived from streptomycin by reduction with hydrogen. The primary mechanism of action of the antibiotic dihydrostreptomycin is binding to and modifying the function of the bacterial ribosome, thus leading to decreased and aberrant translation of proteins, in addition it binds mechanosensitive channel of large conductance (MscL) and modifies its conformation, thus allowing the passage of K+ and glutamate out of, and dihydrostreptomycin into, the cell. It has about the same degree of antibacterial activity as streptomycin, but it is less effective against some gram-negative microorganisms. Because it has a higher risk of irreversible deafness, and its effectiveness is no greater that that of streptomycin, dihydrostreptomycin is no longer used clinically. To date dihydrostreptomycin is approved for veterinary use to treat bacterial infections.
Sulfamethazine is a sulfonamide used to treat a variety of bacterial diseases in animals. It inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase (dihydrofolate synthetase).
Status:
Possibly Marketed Outside US
Source:
Milltrium Senior Vitamin and Mineral Supplement by Garden State Nutritionals [Canada]
Source URL:
First approved in 2015
Source:
Vita-Rx Diabetic Vitamin by Pure Source, LLC
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

There is no information about pharmacological and biological application of vanadium pentoxide (V2O5). However, inhalation of this substance is a toxic for mammalian and repeated exposures to V2O5 containing particles may augment lung carcinogenesis in susceptible individuals through oxidative stress mediated pathways.
Status:
Possibly Marketed Outside US
Source:
Milltrium Senior Vitamin and Mineral Supplement by Garden State Nutritionals [Canada]
Source URL:
First approved in 2015
Source:
Vita-Rx Diabetic Vitamin by Pure Source, LLC
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

There is no information about pharmacological and biological application of vanadium pentoxide (V2O5). However, inhalation of this substance is a toxic for mammalian and repeated exposures to V2O5 containing particles may augment lung carcinogenesis in susceptible individuals through oxidative stress mediated pathways.
Status:
Possibly Marketed Outside US
Source:
Milltrium Senior Vitamin and Mineral Supplement by Garden State Nutritionals [Canada]
Source URL:
First approved in 2015
Source:
Vita-Rx Diabetic Vitamin by Pure Source, LLC
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

There is no information about pharmacological and biological application of vanadium pentoxide (V2O5). However, inhalation of this substance is a toxic for mammalian and repeated exposures to V2O5 containing particles may augment lung carcinogenesis in susceptible individuals through oxidative stress mediated pathways.
Status:
Possibly Marketed Outside US
Source:
Milltrium Senior Vitamin and Mineral Supplement by Garden State Nutritionals [Canada]
Source URL:
First approved in 2015
Source:
Vita-Rx Diabetic Vitamin by Pure Source, LLC
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

There is no information about pharmacological and biological application of vanadium pentoxide (V2O5). However, inhalation of this substance is a toxic for mammalian and repeated exposures to V2O5 containing particles may augment lung carcinogenesis in susceptible individuals through oxidative stress mediated pathways.
Status:
Possibly Marketed Outside US
Source:
Milltrium Senior Vitamin and Mineral Supplement by Garden State Nutritionals [Canada]
Source URL:
First approved in 2015
Source:
Vita-Rx Diabetic Vitamin by Pure Source, LLC
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

There is no information about pharmacological and biological application of vanadium pentoxide (V2O5). However, inhalation of this substance is a toxic for mammalian and repeated exposures to V2O5 containing particles may augment lung carcinogenesis in susceptible individuals through oxidative stress mediated pathways.