PENICILLIN V HYDRABAMINE

US Previously Marketed

First approved in 1954

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C42H64N2.2C16H18N2O5S
Molecular Weight	1297.75
Optical Activity	UNSPECIFIED
Defined Stereocenters	12 / 12
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)COC3=CC=CC=C3)C(O)=O.[H][C@]45SC(C)(C)[C@@H](N4C(=O)[C@H]5NC(=O)COC6=CC=CC=C6)C(O)=O.[H][C@@]78CCC9=C(C=CC(=C9)C(C)C)[C@@]7(C)CCC[C@@]8(C)CNCCNC[C@]%10(C)CCC[C@]%11(C)C%12=C(CC[C@@]%10%11[H])C=C(C=C%12)C(C)C

InChI

InChIKey=IJXFBPWHGGIUAV-YQUITFMISA-N

InChI=1S/C42H64N2.2C16H18N2O5S/c1-29(2)31-11-15-35-33(25-31)13-17-37-39(5,19-9-21-41(35,37)7)27-43-23-24-44-28-40(6)20-10-22-42(8)36-16-12-32(30(3)4)26-34(36)14-18-38(40)42;2*1-16(2)12(15(21)22)18-13(20)11(14(18)24-16)17-10(19)8-23-9-6-4-3-5-7-9/h11-12,15-16,25-26,29-30,37-38,43-44H,9-10,13-14,17-24,27-28H2,1-8H3;2*3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t37-,38-,39-,40-,41+,42+;2*11-,12+,14-/m011/s1

HIDE SMILES / InChI

Description
Sources: https://www.drugfuture.com/chemdata/Penicillin-V-Hydrabamine.html | http://pharmacycode.com/Compocillin_V.html

PENICILLIN V HYDRABAMINE, a semi-synthetic antibiotic, is used for the treatment of mild to moderately severe infections (e.g. dental infection, infections in the heart, middle ear infections, rheumatic fever, scarlet fever, skin infections, upper and lower respiratory tract infections) caused by susceptible, usually gram-positive, organisms.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Bacterial Infections 63 Sources: https://books.google.ru/books?id=bAg6AAAAIAAJ&pg=PA368&lpg=PA368&dq=PENICILLIN+V+HYDRABAMINE retrieved from The Code of Federal Regulations of the United States of America, p.368	Curative		Approved 8429	Compocillin-V Approved Use Antibacterial Launch Date -5.04921588E11

C_max

Value	Dose	Co-administered	Analyte	Population
5.73 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/809408/	500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered:		PENICILLIN V plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
8.23 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/809408/	500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered:		PENICILLIN V plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/809408/	500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered:		PENICILLIN V plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED

F_unbound

Value	Dose	Co-administered	Analyte	Population
20% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/809408/	500 mg single, oral dose: 500 mg route of administration: Oral experiment type: SINGLE co-administered:		PENICILLIN V plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED

Sourcing

Vendor/Aggregator	ID	URL
ChemIDplus	6591726	https://chem.nlm.nih.gov/chemidplus/id/0006591726
KEGG	D05413	http://www.genome.jp/dbget-bin/www_bget?dr:D05413
PubChem	23724984	https://pubchem.ncbi.nlm.nih.gov/compound/23724984
Wikidata	Q27123286

PubMed

Title	Date	PubMed
Penicillin V blood levels after oral administration of the benzathine and hydrabamine salts.	1960 Oct 8	13752162

Name

Type

Language

PENICILLIN V HYDRABAMINE

Official Name

English

ABBOCILLIN V

Common Name

English

COMPOCILLIN V HYDRABAMINE

Common Name

English

PENICILLIN V HYDRABAMINE [USAN]

Common Name

English

COMPOCILLIN V

Common Name

English

PHENOXYMETHYLPENICILLIN HYDRABAMINE

Common Name

English

HYDRABAMINE PHENOXYMETHYLPENICILLIN

Common Name

English

PENICILLIN PHENOXYMETHYL HYDRABAMINE

Common Name

English

HYDRABAMINE PHENOXYMETHYLPENICILLIN [MART.]

Common Name

English

Phenoxymethylpenicillin hydrabamine [WHO-DD]

Common Name

English

HYDRABAMINE PENICILLIN V

Common Name

English

PENICILLIN HYDRABAMINE PHENOXYMETHYL

Common Name

English

PENICILLIN V HYDRABAMINE [MI]

Common Name

English

Code System Code Type Description

PUBCHEM

23724984