PENICILLIN V

First approved in 1955

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H18N2O5S
Molecular Weight	350.39
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)COC3=CC=CC=C3)C(O)=O

InChI

InChIKey=BPLBGHOLXOTWMN-MBNYWOFBSA-N

InChI=1S/C16H18N2O5S/c1-16(2)12(15(21)22)18-13(20)11(14(18)24-16)17-10(19)8-23-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12+,14-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C16H18N2O5S
Molecular Weight	350.39
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.drugbank.ca/drugs/DB00417
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/064071s006lbl.pdf

Penicillin V is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Penicillin V has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Penicillin V results from the inhibition of cell wall synthesis and is mediated through Penicillin V binding to penicillin binding proteins (PBPs). Penicillin V is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Penicillin V inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Penicillin V interferes with an autolysin inhibitor. Used for the treatment of mild to moderately severe infections (e.g. dental infection, infections in the heart, middle ear infections, rheumatic fever, scarlet fever, skin infections, upper and lower respiratory tract infections) due to microorganisms.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Staphylococcus aureus 67 Target ID: CHEMBL352 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16495241	Inhibitor 8297
Penicillin-binding protein 1A 45 Target ID: Q8XJ01 Gene ID: 990276.0 Gene Symbol: pbpA Target Organism: Clostridium perfringens (strain 13 / Type A) Sources: http://www.drugbank.ca/drugs/DB00417	Inhibitor 8297
Penicillin-binding protein 2a 17 Target ID: CHEMBL3512 Sources: http://www.drugbank.ca/drugs/DB00417	Inhibitor 8297
Streptococcus pneumoniae 25 Target ID: CHEMBL347 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3172134	Inhibitor 8297
Bacterial penicillin-binding protein 233 Target ID: CHEMBL2354204 Sources: http://www.genome.jp/dbget-bin/www_bget?D05411+D00497+D08360	Inhibitor 8297

Conditions

Condition	Modality	Highest Phase	Product
Pneumococcal infections 9 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/064071s006lbl.pdf	Curative	Approved 8429	Penicillin V Approved Use Penicillin V potassium tablets and Penicillin V potassium for oral solution are indicated in the treatment of mild to moderately severe infections due to penicillin G-sensitive microorganisms. Therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response. The following infections will usually respond to adequate dosage of Penicillin V. Streptococcal infections (without bacteremia). Mild-to-moderate infections of the upper respiratory tract, scarlet fever, and mild erysipelas. Pneumococcal infections. Mild to moderately severe infections of the respiratory tract. Staphylococcal infections—penicillin G-sensitive. Mild infections of the skin and soft tissues. Fusospirochetosis (Vincent's gingivitis and pharyngitis)—Mild to moderately severe infections of the oropharynx usually respond to therapy with oral penicillin. Launch Date 1990
Streptococcal infections 11 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/064071s006lbl.pdf	Curative	Approved 8429	Penicillin V Approved Use Penicillin V potassium tablets and Penicillin V potassium for oral solution are indicated in the treatment of mild to moderately severe infections due to penicillin G-sensitive microorganisms. Therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response. The following infections will usually respond to adequate dosage of Penicillin V. Streptococcal infections (without bacteremia). Mild-to-moderate infections of the upper respiratory tract, scarlet fever, and mild erysipelas. Pneumococcal infections. Mild to moderately severe infections of the respiratory tract. Staphylococcal infections—penicillin G-sensitive. Mild infections of the skin and soft tissues. Fusospirochetosis (Vincent's gingivitis and pharyngitis)—Mild to moderately severe infections of the oropharynx usually respond to therapy with oral penicillin. Launch Date 1990
Staphylococcal infections 24 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/064071s006lbl.pdf	Curative	Approved 8429	Penicillin V Approved Use Penicillin V potassium tablets and Penicillin V potassium for oral solution are indicated in the treatment of mild to moderately severe infections due to penicillin G-sensitive microorganisms. Therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response. The following infections will usually respond to adequate dosage of Penicillin V. Streptococcal infections (without bacteremia). Mild-to-moderate infections of the upper respiratory tract, scarlet fever, and mild erysipelas. Pneumococcal infections. Mild to moderately severe infections of the respiratory tract. Staphylococcal infections—penicillin G-sensitive. Mild infections of the skin and soft tissues. Fusospirochetosis (Vincent's gingivitis and pharyngitis)—Mild to moderately severe infections of the oropharynx usually respond to therapy with oral penicillin. Launch Date 1990

C_max

Value	Dose	Analyte	Population
15 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6811219	1 g single, oral dose: 1 g route of administration: Oral experiment type: SINGLE co-administered:	PENICILLIN V POTASSIUM serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
26.3 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6811219	2 g single, oral dose: 2 g route of administration: Oral experiment type: SINGLE co-administered:	PENICILLIN V POTASSIUM serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
35.5 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6811219	3 g single, oral dose: 3 g route of administration: Oral experiment type: SINGLE co-administered:	PENICILLIN V POTASSIUM serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
6.1 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6811219	0.4 g single, oral dose: 0.4 g route of administration: Oral experiment type: SINGLE co-administered:	PENICILLIN V POTASSIUM serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

AUC

Value	Dose	Analyte	Population
19.01 mg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6811219	1 g single, oral dose: 1 g route of administration: Oral experiment type: SINGLE co-administered:	PENICILLIN V POTASSIUM serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
33.36 mg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6811219	2 g single, oral dose: 2 g route of administration: Oral experiment type: SINGLE co-administered:	PENICILLIN V POTASSIUM serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
43.94 mg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6811219	3 g single, oral dose: 3 g route of administration: Oral experiment type: SINGLE co-administered:	PENICILLIN V POTASSIUM serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
6.89 mg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6811219	0.4 g single, oral dose: 0.4 g route of administration: Oral experiment type: SINGLE co-administered:	PENICILLIN V POTASSIUM serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

T_1/2

Value	Dose	Analyte	Population
0.78 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6811219	1 g single, oral dose: 1 g route of administration: Oral experiment type: SINGLE co-administered:	PENICILLIN V POTASSIUM serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
0.91 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6811219	2 g single, oral dose: 2 g route of administration: Oral experiment type: SINGLE co-administered:	PENICILLIN V POTASSIUM serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
1.05 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6811219	3 g single, oral dose: 3 g route of administration: Oral experiment type: SINGLE co-administered:	PENICILLIN V POTASSIUM serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
0.52 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6811219	0.4 g single, oral dose: 0.4 g route of administration: Oral experiment type: SINGLE co-administered:	PENICILLIN V POTASSIUM serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

F_unbound

Value	Dose	Co-administered	Analyte	Population
20% DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/064071s006lbl.pdf	unknown, oral		PENICILLIN V POTASSIUM serum	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
10 mg/kg 4 times / day multiple, oral Recommended Dose: 10 mg/kg, 4 times / day Route: oral Route: multiple Dose: 10 mg/kg, 4 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/9006528 Page: p.48	unhealthy, 1-12 n = 216 Health Status: unhealthy Condition: Streptococcal Pharyngitis Age Group: 1-12 Sex: M+F Population Size: 216 Sources: https://pubmed.ncbi.nlm.nih.gov/9006528 Page: p.48	Disc. AE: Stomach cramps, Nausea... Other AEs: Diarrhea, Rash... AEs leading to discontinuation/dose reduction: Stomach cramps (0.46%) Nausea (0.46%) Other AEs: Diarrhea (0.8%) Rash (1.2%) Abdominal pain (0.8%) Infection (1.7%) Headache (1.2%) Vomiting (2.5%) Rhinitis (1.2%) Gastroenteritis (0.4%) Epistaxis (0.4%) Ear pain (2.1%) Cough increased (1.2%) Nausea (0.8%) Sources: https://pubmed.ncbi.nlm.nih.gov/9006528 Page: p.48
250 mg 4 times / day multiple, oral Recommended Dose: 250 mg, 4 times / day Route: oral Route: multiple Dose: 250 mg, 4 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/1656738 Page: p.3A-25S	unhealthy, 16+ n = 117 Health Status: unhealthy Condition: Streptococcal Pharyngitis Age Group: 16+ Sex: M+F Population Size: 117 Sources: https://pubmed.ncbi.nlm.nih.gov/1656738 Page: p.3A-25S	Disc. AE: Abdominal pain... AEs leading to discontinuation/dose reduction: Abdominal pain (1.7%) Sources: https://pubmed.ncbi.nlm.nih.gov/1656738 Page: p.3A-25S
590 mg 3 times / day multiple, oral Recommended Dose: 590 mg, 3 times / day Route: oral Route: multiple Dose: 590 mg, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/11815577 Page: p.341	unhealthy, 28+/-7.9 n = 113 Health Status: unhealthy Condition: Streptococcal Pharyngitis Age Group: 28+/-7.9 Sex: M+F Population Size: 113 Sources: https://pubmed.ncbi.nlm.nih.gov/11815577 Page: p.341	Disc. AE: Nausea, Taste alteration... AEs leading to discontinuation/dose reduction: Nausea (grade 3, 0.88%) Taste alteration (grade 3, 0.88%) Sources: https://pubmed.ncbi.nlm.nih.gov/11815577 Page: p.341
800 mg 4 times / day multiple, oral Highest studied dose Dose: 800 mg, 4 times / day Route: oral Route: multiple Dose: 800 mg, 4 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/31585944	unhealthy, 30.0 (6–73) n = 212 Health Status: unhealthy Condition: Pharyngotonsillitis caused by group A streptococci Age Group: 30.0 (6–73) Sex: M+F Population Size: 212 Sources: https://pubmed.ncbi.nlm.nih.gov/31585944	Sources: https://pubmed.ncbi.nlm.nih.gov/31585944
1 g 3 times / day multiple, oral Recommended Dose: 1 g, 3 times / day Route: oral Route: multiple Dose: 1 g, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/31585944	unhealthy, 31.0 (3–67) n = 210 Health Status: unhealthy Condition: Pharyngotonsillitis caused by group A streptococci Age Group: 31.0 (3–67) Sex: M+F Population Size: 210 Sources: https://pubmed.ncbi.nlm.nih.gov/31585944	Sources: https://pubmed.ncbi.nlm.nih.gov/31585944
3 g multiple, oral Recommended Dose: 3 g Route: oral Route: multiple Dose: 3 g Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/064071s006lbl.pdf Page: p.2	unhealthy Health Status: unhealthy Condition: Prophylaxis against bacterial endocarditis Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/064071s006lbl.pdf Page: p.2	Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/064071s006lbl.pdf Page: p.2
250 mg 4 times / day multiple, oral Recommended Dose: 250 mg, 4 times / day Route: oral Route: multiple Dose: 250 mg, 4 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/1428189 Page: p.70/306	unhealthy n = 175 Health Status: unhealthy Condition: Streptococcal pharyngitis\|Streptococcal tonsillitis Sex: M+F Population Size: 175 Sources: https://pubmed.ncbi.nlm.nih.gov/1428189 Page: p.70/306	Disc. AE: Rash, Vomiting... AEs leading to discontinuation/dose reduction: Rash (0.57%) Vomiting (0.57%) Sources: https://pubmed.ncbi.nlm.nih.gov/1428189 Page: p.70/306
500 mg 4 times / day multiple, oral (max) Recommended Dose: 500 mg, 4 times / day Route: oral Route: multiple Dose: 500 mg, 4 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/064071s006lbl.pdf Page: p.2	unhealthy Health Status: unhealthy Condition: Infections due to penicillin G sensitive microorganisms Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/064071s006lbl.pdf Page: p.2	Disc. AE: Hypersensitivity reaction, Diarrhea, Clostridium difficile... AEs leading to discontinuation/dose reduction: Hypersensitivity reaction (serious\|grade 5) Diarrhea, Clostridium difficile (mild\|grade 5) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/064071s006lbl.pdf Page: p.2

AEs

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-053377	http://www.3bsc.com/index/pro_info.php?id=91842
AHH Chemical co.,ltd	MT-57705	http://www.ahhchemical.com/product/MT-57705.html
Alfa Chemistry	AP87081	https://reagents.alfa-chemistry.com/product/penicillin-v-cas-87-08-1-17587.html
Aurora Fine Chemicals LLC	A17.930.778	http://online.aurorafinechemicals.com/info?ID=A17.930.778
Aurora Fine Chemicals LLC	K14.717.682	http://online.aurorafinechemicals.com/info?ID=K14.717.682
Avantor Inc	101095-750	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101095-750
BLD Pharm	BD290184	http://www.bldpharm.com/products/87-08-1.html
BioSynth	W-109316	https://www.biosynth.com/en/products/life-science/culture-media-additives/products/W-109316.html
Glentham Life Sciences	GA2160	http://www.glentham.com/products/product/GA2160/
Hairui	HR140122	http://www.hairuichem.com/en/product/87-08-1.html
LGC Standards	DRE-A16045500AL-100	https://www.lgcstandards.com/US/en/p/DRE-A16045500AL-100
LGC Standards	DRE-C16045500	https://www.lgcstandards.com/US/en/p/DRE-C16045500
Lab Network	LN01343665	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN01343665
MuseChem	R062176	https://www.musechem.com/product/R062176.html
Sigma-Aldrich	P1000000_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/p1000000?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	1504489_USP	https://www.sigmaaldrich.com/catalog/product/usp/1504489?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule	S571986	https://www.smolecule.com/products/s571986
THE BioTek	bt-311879	https://www.thebiotek.com/product/others/bt-311879

PubMed

Title	Date	PubMed
[The antiviral activity of the antibiotics beromycin and carminomycin].	1974 Feb	4219122
[Immune hemolytic anemia and thrombocytopenia after peroral therapy with a penicillin derivative (phenoxymethylpenicillin)].	1977	415731
Assessment of the "E' book as a tool for drug monitoring.	1981 Mar	6790651
[Leukocytoclastic vasculitis due to drug allergy presenting as generalized pustular exanthema].	1981 Sep	6268571
Effect of drugs influencing synthesis of prostaglandins on haloperidol-induced catalepsy in rats.	1984 Jul-Sep	6440863
Loracarbef versus penicillin VK in the treatment of streptococcal pharyngitis and tonsillitis in an adult population.	1992 Jun 22	1621750
Antioxidant vitamins improves hemoglobin level in children with group a beta hemolytic streptococcal infection.	2003 Jul	12894046
Recurrent pneumococcal meningitis in a splenectomised HIV-infected patient.	2003 Nov 7	14613586
Immunological response to antioxidant vitamin supplementation in rural Bangladeshi school children with group A streptococcal infection.	2004	15331332
Data from electronic patient records are suitable for surveillance of antibiotic prescriptions for respiratory tract infections in primary health care.	2004	15061670
Acute sinusitis: guide to selection of antibacterial therapy.	2004	15059037
Antibiotics for acute group A streptococcal pharyngitis.	2004 Dec	15612147
Specific serum IgE levels and FcepsilonRIbeta genetic polymorphism in patients with penicillins allergy.	2004 Dec	15507102
[Bite wound infections].	2004 Dec 16	15608763
Limited spread of penicillin-nonsusceptible pneumococci, Skåne County, Sweden.	2004 Jun	15207061
[Prevention and infection in adults patients with hyposplenism].	2004 Nov	15620052
Tick-borne encephalopathies : epidemiology, diagnosis, treatment and prevention.	2005	16332143
Antigen specific quantification of sulfidoleukotrienes in patients allergic to Betalactam antibiotics.	2005	15864881
Relationships between skin test, specific IgE and levels of cytokines in patients with penicillin allergy.	2005 Aug	16033609
Community prescribing and resistant Streptococcus pneumoniae.	2005 Jun	15963276
Inadvertent use of Bicillin C-R to treat syphilis infection--Los Angeles, California, 1999-2004.	2005 Mar 11	15758893
Tigecycline: an evidence-based review of its antibacterial activity and effectiveness in complicated skin and soft tissue and intraabdominal infections.	2006	22500153
Facilitated column selection in pharmaceutical analyses using a simple column classification system.	2006 Jan 6	16242136
Hypersensitivity to penicillin V with good tolerance to other beta-lactams.	2007	17323864
Meningomylocele: An update.	2007 Apr	19675798
Comparative bioavailability study of two phenoxymethylpenicillin potassium tablet formulations in healthy volunteers.	2007 Dec	18184536
Aminopenicillin-induced exanthema allows treatment with certain cephalosporins or phenoxymethyl penicillin.	2007 Jul	17510067
Dishing the dirt on asthma: What we can learn from poor hygiene.	2007 Jun	19707324
Leukocyte counts in urine reflect the risk of concomitant sepsis in bacteriuric infants: a retrospective cohort study.	2007 Jun 13	17567901
Evaluation of phenoxymethylpenicillin treatment of acute otitis media in children aged 2-16.	2007 Sep	17846935
Effects of treatment with antimicrobial agents on the human colonic microflora.	2008 Dec	19337440
[Summary of the practice guideline 'Sore throat' (second revision) from the Dutch College of General Practitioners].	2008 Feb 23	18361191
Antimicrobial susceptibility of periodontopathogenic bacteria.	2008 May	18326855
Treatment of Lyme borreliosis.	2009	20067594
Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A beta-Hemolytic Streptococcus pharyngitis in Children.	2009	20041005
Treatment and prevention of Lyme disease.	2009	19367098
The role of phenoxymethylpenicillin, amoxicillin, metronidazole and clindamycin in the management of acute dentoalveolar abscesses--a review.	2009 Apr 11	19357666
Antibiotic prescribing in paediatric populations: a comparison between Viareggio, Italy and Funen, Denmark.	2009 Aug	19349289
Challenges of cellulitis in a lymphedematous extremity: a case report.	2009 Dec 22	20062550
Hypersensitivity reactions to penicillins: studies in a group of patients with negative benzylpenicillin G skin test.	2009 Jun	19646073
Specific IgG antibodies in sera in patients with penicillin allergy.	2009 Jun	19067119
Acute tonsillopharyngitis in a family practice in Mostar, Bosnia and Herzegovina.	2009 Mar	19408639
[An exceptional component C3 deficiency revealed by serum protein electrophoresis].	2009 Nov-Dec	19939777
Antibiotic prescribing practices by dentists: a review.	2010 Jul 21	20668712
Human health risk assessment of pharmaceuticals in water: issues and challenges ahead.	2010 Nov	21139869
How are antibacterials used in nursing homes? Results from a point-prevalence prescription study in 44 Norwegian nursing homes.	2010 Oct	20712026
Prevalence of Group A b-Hemolytic Streptococcus Among Children with Tonsillopharyngitis in Kyrgyzstan: The Difficulty of Diagnostics and Therapy.	2010 Oct 13	21253454
Evaluation of the sensitizing potential of antibiotics in vitro using the human cell lines THP-1 and MUTZ-LC and primary monocyte-derived dendritic cells.	2012 Aug 1	22609641
Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity.	2012 Feb	22112502
Synthesis of novel hapten and production of generic monoclonal antibody for immunoassay of penicillins residues in milk.	2013	23452214

Patents

Sample Use Guides

In Vivo Use Guide

Usual Adult Dose for Bacterial Infection Mild to moderate infections: 125 to 500 mg orally every 6 to 8 hours

Route of Administration: Oral

In Vitro Use Guide

Penicillin V inhibited Staphylococcus aureus in human THP-1 macrophages (intracellular) with MIC90 of 0.015 mg/L

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:05:31 GMT 2023` Edited by `admin` on `Sat Dec 16 18:05:31 GMT 2023`
Record UNII	Z61I075U2W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PENICILLIN V

Official Name

English

PENICILLIN V [HSDB]

Common Name

English

VEBECILLIN

Common Name

English

phenoxymethylpenicillin [INN]

Common Name

English

PHENOXYMETHYLPENICILLIN [WHO-IP]

Common Name

English

PENICILLIN PHENOXYMETHYL

Common Name

English

PENICILLIN V [USP-RS]

Common Name

English

PENICILLIN V [ORANGE BOOK]

Common Name

English

PHENOXYMETHYLPENICILLIN

Official Name

English

DISTAQUAINE V

Common Name

English

PHENOXYMETHYLPENICILLIN [MART.]

Common Name

English

PHENOXYMETHYLPENICILLIN [EP MONOGRAPH]

Common Name

English

4-THIA-1-AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC ACID, 3,3-DIMETHYL-7-OXO-6-((PHENOXYACETYL)AMINO)-, (2S-(2.ALPHA.,5.ALPHA.,6.BETA.))-

Common Name

English

PENICILLIN V [MI]

Common Name

English

Phenoxymethylpenicillin [WHO-DD]

Common Name

English

PENICILLIN V [USP MONOGRAPH]

Common Name

English

PHENOXYMETHYLPENICILLINUM [WHO-IP LATIN]

Common Name

English

(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Systematic Name

English

V-CILLIN

Brand Name

English

PENICILLIN V [USAN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QJ01CE02