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Details

Stereochemistry ABSOLUTE
Molecular Formula C42H64N2.2C16H18N2O5S
Molecular Weight 1297.75
Optical Activity UNSPECIFIED
Defined Stereocenters 12 / 12
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PENICILLIN V HYDRABAMINE

SMILES

CC1(C)S[C@@H]2[C@H](NC(=O)COC3=CC=CC=C3)C(=O)N2[C@H]1C(O)=O.CC4(C)S[C@@H]5[C@H](NC(=O)COC6=CC=CC=C6)C(=O)N5[C@H]4C(O)=O.CC(C)C7=CC=C8C(CC[C@H]9[C@](C)(CNCCNC[C@]%10(C)CCC[C@@]%11(C)[C@H]%10CCC%12=C%11C=CC(=C%12)C(C)C)CCC[C@]89C)=C7

InChI

InChIKey=IJXFBPWHGGIUAV-YQUITFMISA-N
InChI=1S/C42H64N2.2C16H18N2O5S/c1-29(2)31-11-15-35-33(25-31)13-17-37-39(5,19-9-21-41(35,37)7)27-43-23-24-44-28-40(6)20-10-22-42(8)36-16-12-32(30(3)4)26-34(36)14-18-38(40)42;2*1-16(2)12(15(21)22)18-13(20)11(14(18)24-16)17-10(19)8-23-9-6-4-3-5-7-9/h11-12,15-16,25-26,29-30,37-38,43-44H,9-10,13-14,17-24,27-28H2,1-8H3;2*3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t37-,38-,39-,40-,41+,42+;2*11-,12+,14-/m011/s1

HIDE SMILES / InChI
Molecular Formula C16H18N2O5S
Molecular Weight 350.39
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula C42H64N2
Molecular Weight 596.971
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 6 / 6
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

PENICILLIN V HYDRABAMINE, a semi-synthetic antibiotic, is used for the treatment of mild to moderately severe infections (e.g. dental infection, infections in the heart, middle ear infections, rheumatic fever, scarlet fever, skin infections, upper and lower respiratory tract infections) caused by susceptible, usually gram-positive, organisms.

Approval Year

1954
119
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8583
Compocillin-V

Approved Use

Antibacterial

Launch Date

1954
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
5.73 μg/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/809408/
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PENICILLIN V plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
8.23 μg × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/809408/
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PENICILLIN V plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/809408/
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PENICILLIN V plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
20%
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/809408/
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PENICILLIN V plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
Sourcing

Sourcing

Vendor/AggregatorIDURL
ChemIDplus
6591726
https://chem.nlm.nih.gov/chemidplus/id/0006591726
KEGG
D05413
http://www.genome.jp/dbget-bin/www_bget?dr:D05413
PubChem
23724984
https://pubchem.ncbi.nlm.nih.gov/compound/23724984
Wikidata
Q27123286
PubMed

PubMed

TitleDatePubMed
Penicillin V blood levels after oral administration of the benzathine and hydrabamine salts.
1960-10-08
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:57:55 GMT 2025
Edited
by admin
on Mon Mar 31 17:57:55 GMT 2025
Record UNII
8T7T79P87L
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PHENOXYMETHYLPENICILLIN HYDRABAMINE
WHO-DD  
Preferred Name English
PENICILLIN V HYDRABAMINE
MI   USAN  
USAN  
Official Name English
ABBOCILLIN V
Common Name English
COMPOCILLIN V HYDRABAMINE
Common Name English
PENICILLIN V HYDRABAMINE [USAN]
Common Name English
COMPOCILLIN V
Common Name English
HYDRABAMINE PHENOXYMETHYLPENICILLIN
MART.  
Common Name English
PENICILLIN PHENOXYMETHYL HYDRABAMINE
Common Name English
HYDRABAMINE PHENOXYMETHYLPENICILLIN [MART.]
Common Name English
Phenoxymethylpenicillin hydrabamine [WHO-DD]
Common Name English
HYDRABAMINE PENICILLIN V
Common Name English
PENICILLIN HYDRABAMINE PHENOXYMETHYL
Common Name English
PENICILLIN V HYDRABAMINE [MI]
Common Name English
Code System Code Type Description
PUBCHEM
23724984
Created by admin on Mon Mar 31 17:57:55 GMT 2025 , Edited by admin on Mon Mar 31 17:57:55 GMT 2025
PRIMARY
MERCK INDEX
m387
Created by admin on Mon Mar 31 17:57:55 GMT 2025 , Edited by admin on Mon Mar 31 17:57:55 GMT 2025
PRIMARY Merck Index
CAS
6591-72-6
Created by admin on Mon Mar 31 17:57:55 GMT 2025 , Edited by admin on Mon Mar 31 17:57:55 GMT 2025
PRIMARY
FDA UNII
8T7T79P87L
Created by admin on Mon Mar 31 17:57:55 GMT 2025 , Edited by admin on Mon Mar 31 17:57:55 GMT 2025
PRIMARY
NCI_THESAURUS
C175188
Created by admin on Mon Mar 31 17:57:55 GMT 2025 , Edited by admin on Mon Mar 31 17:57:55 GMT 2025
PRIMARY
SMS_ID
100000085295
Created by admin on Mon Mar 31 17:57:55 GMT 2025 , Edited by admin on Mon Mar 31 17:57:55 GMT 2025
PRIMARY
EVMPD
SUB03765MIG
Created by admin on Mon Mar 31 17:57:55 GMT 2025 , Edited by admin on Mon Mar 31 17:57:55 GMT 2025
PRIMARY
CHEBI
52173
Created by admin on Mon Mar 31 17:57:55 GMT 2025 , Edited by admin on Mon Mar 31 17:57:55 GMT 2025
PRIMARY
Related Record Type Details
Structure of PENICILLIN V
PARENT -> SALT/SOLVATE
NIH
NCATS
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