Stereochemistry | ACHIRAL |
Molecular Formula | C16H20N2 |
Molecular Weight | 240.3434 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C(CNCC1=CC=CC=C1)NCC2=CC=CC=C2
InChI
InChIKey=JUHORIMYRDESRB-UHFFFAOYSA-N
InChI=1S/C16H20N2/c1-3-7-15(8-4-1)13-17-11-12-18-14-16-9-5-2-6-10-16/h1-10,17-18H,11-14H2
Molecular Formula | C16H20N2 |
Molecular Weight | 240.3434 |
Charge | 0 |
Count |
MOL RATIO
1 MOL RATIO (average) |
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Benzathine is a diamine used as a component in some medications including benzathine phenoxymethylpenicillin and benzathine benzylpenicillin. Benzathine stabilises penicillin and prolongs its sojourn when injected into tissues. Benzathine have some hepatitis C virus inhibitorion activity in in vitro assay
Originator
Approval Year
Sample Use Guides
0.72g (1.2 million units) IM as a single dose as Benzathine benzylpenicillin.
0.72g Benzathine benzylpenicillin contains 0.19g of Benzathine and 0.53g of benzylpenicillin
Route of Administration:
Intramuscular
Huh-7 replicon cells were plated at 2000 cells/well in 40 mkL of culture media in 384-well plates. After overnight incubation, serially diluted BENZATHINE in 20 mkL of cell culture media were added. At 72 h post BENZATHINE treatment, plates with GFP expressing replicon cell lines were fixed with 2% paraformaldehyde (PFA) and applied for nuclei staining with 10 mkg/mL of Hoechst 33342 (Sigma Aldrich). Cells were visualized by fully automated confocal microscopy (Opera, PerkinElmer) and analyzed by in-house software. HCV RNA replication was measured by GFP expression and cytotoxicity was measured by nucleus counting.