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Details

Stereochemistry ACHIRAL
Molecular Formula C16H20N2
Molecular Weight 240.3434
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BENZATHINE

SMILES

C(CNCC1=CC=CC=C1)NCC2=CC=CC=C2

InChI

InChIKey=JUHORIMYRDESRB-UHFFFAOYSA-N
InChI=1S/C16H20N2/c1-3-7-15(8-4-1)13-17-11-12-18-14-16-9-5-2-6-10-16/h1-10,17-18H,11-14H2

HIDE SMILES / InChI

Molecular Formula C16H20N2
Molecular Weight 240.3434
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Benzathine is a diamine used as a component in some medications including benzathine phenoxymethylpenicillin and benzathine benzylpenicillin. Benzathine stabilises penicillin and prolongs its sojourn when injected into tissues. Benzathine have some hepatitis C virus inhibitorion activity in in vitro assay

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
0.72g (1.2 million units) IM as a single dose as Benzathine benzylpenicillin. 0.72g Benzathine benzylpenicillin contains 0.19g of Benzathine and 0.53g of benzylpenicillin
Route of Administration: Intramuscular
In Vitro Use Guide
Huh-7 replicon cells were plated at 2000 cells/well in 40 mkL of culture media in 384-well plates. After overnight incubation, serially diluted BENZATHINE in 20 mkL of cell culture media were added. At 72 h post BENZATHINE treatment, plates with GFP expressing replicon cell lines were fixed with 2% paraformaldehyde (PFA) and applied for nuclei staining with 10 mkg/mL of Hoechst 33342 (Sigma Aldrich). Cells were visualized by fully automated confocal microscopy (Opera, PerkinElmer) and analyzed by in-house software. HCV RNA replication was measured by GFP expression and cytotoxicity was measured by nucleus counting.
Substance Class Chemical
Record UNII
C659VZ7P7T
Record Status Validated (UNII)
Record Version